DEGRADATION OF AROMATIC AND HALOGENATED COMPOUNDS

芳香族和卤代化合物的降解

• 批准号: 2155199
• 负责人: HAROLD M. GOFF
• 金额: $ 14.99万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2155199
• 关键词: chemical synthesis; chlorohydrocarbon; cycloalkene; detoxification; halogenation; metal complex; oxidation; peroxides; porphyrins

The overall goal of this project is to devise synthetic metal complexes that will promote the incorporation of both oxygen atoms of dioxygen into selected organic substrates. The prototype metal complexes would have considerable utility for synthesis of organic compounds, and would be of potential value for amelioration of environmental contamination by aromatic compounds and chlorinated hydrocarbons. The rationale for attempted development of this new oxidation route is found in the known dioxygenase enzymatic chemistry of microbes that are responsible for oxidation and de-aromatization of aromatic compounds to the cis- dihydrodiol form. This enzymatic system is also effective for oxidative dehalogenation of the priority pollutant trichloroethylene. The microbial dioxygenase enzymes utilize molecular oxygen, NADH, and a putative monomeric iron(II) active site. No model compound work has been performed on this class of enzymes, and the aryl dioxygenation reaction is unprecedented in organic chemistry. Efforts will be made to emulate the chemistry by preparation and activation of peroxide and related O-O ligands on iron and manganese porphyrins and other iron chelated complexes. Systematic reactivity studies will be carried out in order to provide strategy for optimization of the reactivity, efficiency, and stability of the prototype metal complexes.

该项目的总体目标是设计合成金属复合物 这将促进将二氧化物的两个氧原子掺入 选定的有机基材。 原型金属配合物将具有 有机化合物合成的大量实用性，将是 改善环境污染的潜在价值 芳香化合物和氯化烃。 理由 在已知的 微生物的二氧酶化学，负责 芳香族化合物的氧化和去芳香化与顺式化合物 二氢二醇形式。 该酶系统也可有效氧化 优先污染物三氯乙烯的去回解。 微生物 二氧酶利用分子氧，nADH和推定的 单体铁（II）活性位点。没有执行模型复合工作 在这类酶上，芳基二氧化反应为 在有机化学中前所未有的。 将努力效仿 通过制备和激活过氧化物和相关的O-O来化学 铁和锰卟啉以及其他铁螯合的配体 复合物。 将进行系统的反应性研究 提供优化反应性，效率和 原型金属配合物的稳定性。