EMF EFFECTS ON MELATONIN HORMONES AND IMMUNITY

电磁场对褪黑激素和免疫力的影响

• 批准号: 2156116
• 负责人: CHARLES GRAHAM
• 金额: $ 26.26万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-28 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2156116
• 关键词: B lymphocyte; T lymphocyte; blood chemistry; cancer risk; circadian rhythms; cortisol; electromagnetic radiation; estradiol; female; hormone biosynthesis; human subject; interleukin 2; male; melatonin; menstrual cycle; natural killer cells; neoplasm /cancer epidemiology; prolactin; radiation immunosuppression; radiobiology; secretion; sleep; testosterone

DESCRIPTION: There is public concern about the health risks of exposure to the electric and magnetic fields generated by power distribution systems. The objective of this program is to provide human data to test two hypotheses about how the epidemiological link between exposure to magnetic fields and increased risk of cancer might come about. The specific aims of the work are to: 1) replicate a previous study indicating that magnetic field exposure at 20 uT suppresses nocturnal melatonin (MLT) in men with low basal level of MLT, and to further define effective field exposure characteristics; 2) determine whether similar effects happen in women; 3) test the hypothesis that exposure- related suppression of MLT is associated with alterations in relevant hormones; and 4) test the hypothesis that exposure-related suppression of MLT is associated with changes in specific immune system components.Three double-blind studies will be performed. Each study will take into account individual differences in basal MLT levels (0200 peak) prior to exposure as well as sensitivity to bright light, a known suppressor of MLT. The first study will replicate their previous human exposure study, and determine the most effective magnetic field type (continuous rotating, intermittent with minimal harmonic content, or intermittent with high harmonic content.) Exposure will be from 2300 to 0700.Blood samples for MLT analysis will be obtained every hour. Samples of testosterone and interleukin 2 will be obtained at 2300, 0300, and 0700. The second study will use similar procedures, except that one group of men and two groups of healthy young women will be included. One group of women will be tested in the luteal and the other in the follicular phase of the menstrual cycle. Half of each group will be exposed to the most effective field from Study 1, and half will be sham exposed. Outcome measures will include MLT, estradiol, prolactin, testosterone, and cortisol. Data from this study will be used to test the hypothesis that magnetic field exposure alters MLT which in turn alters estradiol and prolactin.A similar design will be used for the fourth study except that immune system components (activated T-cell counts and function; B- cell function, natural killer cell function, selected cytokines) will be the outcome measures. Information of the type to be obtained in the proposed research is needed to aid in risk assessment, and, if no meaningful effects are found, to alleviate unwarranted public concern.

描述：公众关注暴露的健康风险 到由电源分布产生的电场和磁场 系统。 该计划的目的是提供人类数据进行测试 关于暴露于暴露之间的流行病学联系的两个假设 磁场和癌症风险增加可能会产生。 这 工作的具体目的是：1）复制先前的研究 表明20 UT处的磁场暴露会抑制夜间 MLT基底水平低的男性的褪黑激素（MLT），并进一步定义 有效的现场暴露特征； 2）确定是否相似 妇女发生影响； 3）检验与暴露相关的假设 MLT的抑制与相关激素的改变有关； 4）检验以下假设，即MLT的暴露相关抑制 与特定免疫系统组件的变化有关。 将进行双盲研究。 每项研究都会接受 在基础MLT水平（0200 Peak）的个人差异之前 暴露以及对明亮光的敏感性，这是已知的抑制器 MLT。 第一项研究将复制他们以前的人类暴露 研究，并确定最有效的磁场类型（连续 旋转，间歇性与最低谐波含量或间歇性 具有高谐波内容。）曝光率为2300至0700.Blood 每小时将获得用于MLT分析的样本。 样本 睾丸激素和白介素2将于2300、0300和0700获得。 第二项研究将使用类似的程序，除了一组 男性和两组健康的年轻女性将包括在内。 一组 女性将在黄体中进行测试，另一个在卵泡中进行测试 月经周期的阶段。 每组的一半将暴露于 研究1中最有效的领域，一半将被假暴露。 结果指标将包括MLT，雌二醇，催乳素，睾丸激素， 和皮质醇。 这项研究的数据将用于检验假设 磁场暴露改变了MLT，从而改变了雌二醇 和催乳素。第四项研究将使用类似的设计 免疫系统成分（激活的T细胞计数和功能； b- 细胞功能，天然杀伤细胞功能，选定的细胞因子）将是 结果措施。 在 需要拟议的研究以帮助进行风险评估，如果没有 发现有意义的效果，以减轻公众的关注。