Predicting Weight Regain Following Weight Loss Using Physiological Measures of Appetite and Energy Expenditure

使用食欲和能量消耗的生理测量来预测减肥后的体重反弹

基本信息

批准号：
10189945
负责人：
MATTHEW R HAYES
金额：
$ 25万
依托单位：
DREXEL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-24 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10189945
关键词：
Address Adipose tissue Affect Appetite Stimulants Basal metabolic rate Behavior Therapy Behavioral Blood Body Composition Body Weight decreased Body mass index Brain Cholecystokinin Control Groups Corpus striatum structure Cues Data Desire for food Development Diet Energy Metabolism Exercise Fasting Fatty acid glycerol esters Food Functional Magnetic Resonance Imaging Future Gastric Emptying Goals Hormonal Hormones Individual Individual Differences Influentials Intervention Leptin Life Style Maintenance Measures Medical Economics Metabolic Metabolism Methods Modality Modeling Modification Muscle Neurosecretory Systems Nutritional Obesity Outcome Measure Overweight Participant Phase Physiological Physiological Adaptation Planning Techniques Process Recording of previous events Relapse Rest Source Taste Perception Techniques Testing Thermogenesis Time Weight Weights and Measures Work advanced analytics base biobank connectome based predictive modeling data mining diabetes prevention program feeding follow up assessment follow-up ghrelin glucagon-like peptide 1 group intervention improved increased appetite insight intervention participants multidisciplinary multimodality neuroimaging novel obesity treatment oxidation programs psychologic recruit relating to nervous system response success total energy expenditure treatment program weight loss intervention weight loss program weight maintenance

项目摘要

PROJECT SUMMARY The success of behavioral weight loss programs is undermined by weight regain. Controversy exists about how much physiological adaptations to the weight reduced state contribute to weight regain. Further, little is known about the relative contributions to relapse of increased metabolic efficiency and increased appetitive drive. Even if metabolic efficiency increases with weight loss, this does not necessarily mean that successful dieters are hypo-metabolic in their weight-reduced state. To address these scientific questions, we will recruit 100 individuals into a weight loss program based on a modified version of the Diabetes Prevention Program. Qualified participants will be assessed at baseline and reassessed if they attain a minimum 7% weight loss (called month 0) and undergo follow-up assessments 2 and 18-months later. Reassessment at month 2 will allow us to study the transition to maintenance as a dynamic process (i.e., change from month 0 to 2), not just as a discrete change of state (from baseline to month 0). A control group of 33 weight-stable overweight individuals, matched to successful weight losers on BMI and other variables, will be recruited at time 0 and compared to weight losers on all outcome measures. Changes in physiological measures of metabolism and appetite during weight loss will be used to predict individual differences in weight regain. By comparing weight-losing to weight-stable individuals, we will develop a unique reference point for interpreting the results of the within-group predictive analyses. Physiological outcome measures will include: 1) energy metabolism (e.g., resting and non-resting energy expenditure, 2) neural indicators of appetitive drive (e.g., striatal activation to food cues and food tastes) and 3) neuroendocrine responses to fasting and fed states (e.g., leptin, GLP-1). A comprehensive biobank of blood, fecal, muscle and adipose tissue will also be collected for future discovery studies. Our measures and expertise will provide new insight into the physiological determinants of weight regain following weight loss that could help improve obesity treatments in the future.

项目概要行为减肥计划的成功会因体重反弹而受到损害。争议存在关于体重减轻状态的生理适应有多少贡献体重反弹。此外，对于增加的复发的相对贡献知之甚少。新陈代谢效率和增加食欲。即使代谢效率随着减肥，这并不一定意味着成功的节食者的代谢水平较低减重状态。为了解决这些科学问题，我们将招募 100 人组成一个基于糖尿病预防计划修改版的减肥计划。合格的参与者将接受基线评估，如果体重达到最低 7%，则重新评估损失（称为第 0 个月）并在 2 个月和 18 个月后进行后续评估。第 2 个月的重新评估将使我们能够将向维护的过渡作为动态研究过程（即从第 0 个月到第 2 个月的变化），而不仅仅是状态的离散变化（从基线到月 0)。对照组由 33 名体重稳定的超重个体组成，与成功的个体相匹配 BMI 和其他变量的减肥者将在时间 0 被招募并与体重进行比较所有结果指标上的失败者。新陈代谢和生理测量的变化减肥期间的食欲将用于预测体重恢复的个体差异。经过通过比较减肥者与体重稳定者，我们将制定一个独特的参考点用于解释组内预测分析的结果。生理结果措施将包括：1）能量代谢（例如静息和非静息能量消耗， 2）食欲驱动的神经指标（例如，纹状体对食物线索和食物味道的激活）和 3) 对禁食和进食状态的神经内分泌反应（例如瘦素、GLP-1）。全面的还将收集血液、粪便、肌肉和脂肪组织的生物库以供未来发现研究。我们的措施和专业知识将为生理决定因素提供新的见解减肥后体重反弹可能有助于改善未来的肥胖治疗。