HEALTH EFFECTS OF AGROCHEMICALS

农用化学品对健康的影响

• 批准号: 2154532
• 负责人: FUMIO none MATSUMURA
• 金额: $ 97.66万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2154532
• 关键词: biomedical facility; environmental toxicology; pesticides

The major goal of this proposed NIEHS Center at the University of California, Davis is to build a strong program in the field of toxicology of agrochemicals, particularly relating to human health. We will place a particularly strong emphasis on mechanistic aspects of toxicology. For this purpose we have assembled a team of 19 active scientists whose interests are specifically aligned with the above goal. They have been selected in such a way that every participant has at least one ongoing NIH supported project. Collectively they are in charge of over $4 million per year (direct costs) of current individual NIH research activities (i.e. R01 funds). In selecting these investigators we have made a special effort to form a blend of young and experienced scientists, fields of interest, and their past history of collaborative works. To build up a proper infrastructure to facilitate truly interactive intragroup relationships, we plan to form seven service cores: (A) Administrative, (B) Cell/Tissue Culture, (C) Molecular Biology, (D) Metabolism, (E) Animal/Inhalation, (F) Biostatistics/Epidemiology, and (G) Morphology. In addition, to promote focused research efforts, intellectual stimulation and synergistic interactions we plan to form four research groups for the initial project period: (1) mechanisms of cell injury, (2) receptor biology, (3) molecular epidemiology, and (4) dynamics of cellular populations. The composition and the organization of the research groups will change from time to time to provide flexibility to the Center research capabilities. To promote genesis of new ideas, concepts and approaches we plan to create a "pilot project" funding mechanism through a peer review system to support even somewhat risky small-scale proposals. The above activities will be aided by monthly seminars specifically designed for the Center needs as well as by annual workshops. We will also develop a visiting scientist program to promote the infusion of new ideas. The overall program direction and operations will be aided by the External and the Internal Advisory Committees. The University of California, Davis will make a strong commitment to support the program. It will provide the salaries of all of the Center investigators, guarantee the availability of the space (including two new renovations for this Center), provide graduate student scholarships, and contribute directly to "pilot projects." The percentage of the UCD contribution for the first year will be 33% (=$344,328).

该拟议的NIEHS中心的主要目标是 加利福尼亚，戴维斯将在该领域建立一个强大的计划 农化学物质的毒理学，尤其是与人类健康有关的毒理学。 我们 将特别强调 毒理学。 为此，我们组建了一个由19个活跃的团队 科学家的兴趣特别与上述目标保持一致。 他们被选中了每个参与者的方式 至少一个正在进行的NIH支持项目。 他们共同在 当前个人每年收取超过400万美元的费用（直接费用） NIH研究活动（即R01基金）。 在选择这些时 调查人员我们做出了特别的努力，以形成年轻人和 经验丰富的科学家，感兴趣的领域及其过去的历史 协作作品。 建立适当的基础设施以促进 真正的互动式内部关系，我们计划形成七个 服务核心：（a）管理，（b）细胞/组织培养，（c） 分子生物学，（d）代谢，（e）动物/吸入，（f） 生物统计学/流行病学和（G）形态。 另外，促进 重点研究工作，智力刺激和协同作用 互动我们计划组成四个研究小组 项目期：（1）细胞损伤的机制，（2）受体生物学，（3） 分子流行病学和（4）细胞种群的动力学。 这 组成和研究小组的组织将从 有时为中心研究功能提供灵活性。 促进计划的新思想，概念和方法的起源 通过同行评审系统创建“试点项目”资金机制 支持甚至有些冒险的小规模建议。 以上 专门设计的每月研讨会将有助于活动 该中心需要以及年度研讨会。 我们还将发展 一项访问科学家计划，以促进新想法的注入。 这 总体计划方向和操作将由外部协助 和内部咨询委员会。 加利福尼亚大学， 戴维斯将做出强烈的承诺支持该计划。 会 提供所有中心调查人员的薪水，保证 空间的可用性（包括两个新的翻新工程 中心），提供研究生奖学金，并直接贡献 到“试点项目”。 UCD贡献的百分比 第一年将为33％（= $ 344,328）。