Electroanatomical Mapping for Shared Translational Research

共享转化研究的电解剖图

• 批准号: 10177076
• 负责人: Alex Y Tan
• 金额: --
• 依托单位: VA VETERANS ADMINISTRATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177076
• 关键词: 3-Dimensional; Ablation; Aging; Anatomy; Anesthesia procedures; Animal Model; Animals; Arrhythmia; Atrial Fibrillation; Blood Vessels; Cardiac; Cardiac Electrophysiologic Techniques; Cardiac ablation; Cardiology; Cardiomyopathies; Catheters; Cells; Collaborations; Complex; Diagnostic; Discipline; Drug Targeting; Electric Stimulation; Electrophysiology (science); Energy-Generating Resources; Equipment; Extramural Activities; Fostering; Frequencies; Funding; Health; Health Benefit; Heart Diseases; Heart failure; High Prevalence; Human; Inflammatory; Injury; Institution; Investigation; Irrigation; Ischemia; Magnetism; Manuals; Manufacturer Name; Measures; Medical center; Medicine; Microelectrodes; Modeling; Morbidity - disease rate; Multiple Sclerosis; Myocardial Infarction; Nerve Degeneration; Neurodegenerative Disorders; Neurology; Noise; Patients; Peripheral; Peripheral Nervous System; Pharmacy facility; Positioning Attribute; Postoperative Period; Pump; Radiofrequency Catheter Ablation; Radiofrequency Interstitial Ablation; Research; Research Personnel; Research Project Grants; Research Proposals; Role; Signal Transduction; System; Techniques; Temperature; Testing; Therapeutic; Time; Tissues; Translational Research; United States National Institutes of Health; Universities; Ventricular Premature Complexes; Veterans; Virginia; cardioprotection; computerized; cytokine; density; design; drug repurposing; experience; experimental study; flexibility; hemodynamics; high dimensionality; improved; improved functioning; medical specialties; military veteran; miniaturize; mortality; neurotransmission; novel; novel therapeutics; open source; pressure; receptor; targeted treatment; translational scientist

PROJECT SUMMARY / ABSTRACT We request funds to acquire the St Jude/Abbott Ensite Precision Electroanatomical Mapping System to facilitate current and new collaborative translational research at Hunter Holmes McGuire VA Medical Center, and collaborations with investigators at Virginia Commonwealth University. This state-of-the- art system can perform diagnostic cardiac electrophysiologic (EP) and hemodynamic studies, high density arrhythmia mapping and therapeutic ablation. 1 Although designed for cardiac and vascular studies, it can be applied to record and stimulate electrical signals in the central and peripheral nervous systems. 2 Its primary role is to replace and upgrade out-of-date equipment critical to core VA-funded research, while expanding avenues of investigation across different specialties (cardiology, anesthesia, neurology, pharmacy) and collaboration with our university affiliate, Virginia Commonwealth University. The equipment’s specific capabilities include to record electrical signals, measure pressure waveforms, electrically stimulate target tissue, apply radiofrequency ablation, perform automated computerized high density 3-dimentional mapping of complex electrical activations during cardiac arrhythmias. Due to its broad capabilities, it can benefit researchers across different subspecialties. In contrast, the current system (GE Prucka CardioLab) has more limited diagnostic capabilities (recording and stimulation but no ablation), and has an out of date manual, sequential mapping system (vs automated) which makes it inadequate for current and future research proposals funded by VA, and extramural agencies such as NIH and AHA. Core VA research projects will investigate novel therapies for postoperative atrial fibrillation (POAF), 3 premature ventricular contraction-induced cardiomyopathy (PVC-CM), 4 5 demyelinating and neurodegenerative conditions 6 and cardioprotective and antiarrhythmic therapies targeted at improving function of mitochrondria, i.e. the cell’s energy sources, in ageing and ischemia related heart disease. 7 Other studies with direct translational applications include the testing of different ablation energies and techniques to optimize safe and effective ablation in human arrhythmia, 8 and testing different anesthesia types in diseased heart models in order to optimize their application in patients. VCU collaborations will utilize the equipment to determine the anti-arrhythmic and cardioprotective mechanisms of novel or ‘repurposed’ drugs that target inflammatory cytokines and their receptors to protect against ischemia-related injury and heart failure. 9,10

项目概要/摘要 我们请求资金购买 St Jude/Abbott Ensite 精密电解剖测绘 促进弗吉尼亚州 Hunter Holmes McGuire 当前和新的合作转化研究的系统 医学中心，以及与弗吉尼亚联邦大学研究人员的合作。 art 系统可以进行诊断性心脏电生理 (EP) 和血流动力学研究、高密度 心律失常标测和治疗性消融 1 虽然是为心脏和血管研究而设计的，但它也可以用于心脏和血管研究。 用于记录和刺激中枢和周围神经系统的电信号2 其主要功能。 其作用是更换和升级对 VA 资助的核心研究至关重要的过时设备，同时扩大 跨不同专业（心脏病学、麻醉学、神经病学、药学）的研究途径 与我们的大学附属机构弗吉尼亚联邦大学合作。 该设备的具体功能包括记录电信号、测量压力 波形，电刺激目标组织，应用射频消融，执行自动计算机化 心律失常期间复杂电激活的高密度 3 维映射。 相比之下，当前的系统具有广泛的功能，可以使不同专业的研究人员受益。 （GE Prucka CardioLab）的诊断能力较为有限（记录和刺激但无消融）， 并且有一个过时的手动顺序映射系统（相对于自动），这使得它不足以 由 VA 以及 NIH 和 AHA 等校外机构资助的当前和未来的研究提案。 VA 核心研究项目将研究术后心房颤动 (POAF) 的新疗法，3 室性早搏诱发的心肌病 (PVC-CM)，4 5 脱髓鞘和 神经退行性疾病 6 以及旨在改善的心脏保护和抗心律失常治疗 线粒体（即细胞的能量来源）在衰老和缺血相关心脏病中的功能 7 其他。 直接转化应用的研究包括测试不同的消融能量和技术 优化人类心律失常的安全有效消融，8 并在患病患者中测试不同的麻醉类型 心脏模型，以优化其在患者中的应用。 VCU 合作将利用该设备来确定抗心律失常和心脏保护作用 针对炎症细胞因子及其受体进行保护的新型或“重新利用”药物的机制 对抗缺血相关损伤和心力衰竭 9,10。

项目成果

Epicardial injection of nanoformulated calcium into cardiac ganglionic plexi suppresses autonomic nerve activity and postoperative atrial fibrillation.

将纳米钙心外膜注射到心脏神经节丛中可抑制自主神经活动和术后心房颤动。

• 发表时间: 2019-04
• 影响因子: 5.5
• 作者: O'Quinn, Michael P;Dormer, Kenneth J;Huizar, Jose F;Nguyen, Kytai T;Kaszala, Karoly;Sima, Adam;Ellenbogen, Kenneth A;Tan, Alex Y
• 通讯作者: Tan, Alex Y