EPIDEMIOLOGY OF NIDDM AND IGT

NIDDM 和 IGT 的流行病学

• 批准号: 2138689
• 负责人: ELIZABETH L BARRETT-CONNOR
• 金额: $ 80.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2138689
• 关键词: blood chemistry; blood glucose; cardiovascular disorder; diabetes mellitus genetics; diabetic angiopathy; diabetic nephropathy; diabetic ophthalmopathy; diabetic retinopathy; diet; disease /disorder proneness /risk; epidemiology; fasting; glucose tolerance test; human middle age (35-64); human morbidity; human mortality; human old age (65+); human subject; hyperglycemia; hyperinsulinism; longitudinal human study; medical complication; metabolism disorder diagnosis; noninsulin dependent diabetes mellitus; nutrition related tag; obesity; questionnaires; sex hormones; statistics /biometry

This proposal is designed to extend prospective studies of the epidemiology of non-insulin dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT) and their comorbidities in the Rancho Bemardo cohort. This defined population of older adults was studied initially in 1972-74, and more extensively in 1984-87. The latter study included 2,859 participants aged 40+, 2480 of whom had a 75 gm oral glucose tolerance test (OGTT). Of the latter, 166 men and 158 women had NIDDM and 237 men and 348 women had IGT, based on World Health Organization criteria. This study included lifestyle and medical histories; anthropometry; blood pressure; lipid and lipoprotein measurements; visual acuity tests; retinal photographs; an electrocardiogram; dietary and psychosocial evaluations; renal functions tests; and (in a subset) hormone measurements. In this proposal we will use the surviving 1984-1987 participants who were characterized for carbohydrate tolerance by OGTT, cardiovascular disease (CVD), eye and renal disease and multiple attributes as the baseline cohort (n = 2480). Some earlier data will also be used to establish stability of attributes (e.g. blood pressure, obesity, lipids, fasting plasma glucose). We propose a repeat evaluation with regard to OGTT, CVD, eye and renal disease, and diverse behavioral, biochemical and endocrinological covariates. This will allow us to determine the incidence and determinants of NIDDM and IGT in older adults. We will also determine morbidity and mortality over time in the presence or absence of abnormal carbohydrate tolerance, and describe in greater detail the characteristics and clustering of complications in a population-based sample of older diabetics, and their relationship cross-sectionally and prospectively to multiple endogenous and exogenous characteristics. We will also extend the mortality follow-up of the cohort long enough to determine whether fasting and/or postchallenge hyperglycemia and/or hyperinsulinemia are risk factors for all cause and cardiovascular death in the elderly or are clinically important concommitants of aging.

该建议旨在扩展对流行病学的前瞻性研究 非胰岛素依赖性糖尿病（NIDDM）和葡萄糖受损 宽容（IGT）及其合并症在兰乔·贝马多（Rancho Bemardo）队列中。 这 最初在1972 - 74年间对老年人的定义人口进行了研究，并 更广泛地在1984 - 87年。 后一项研究包括2,859名参与者 年龄40岁以上，其中2480个有75克口服葡萄糖耐量测试（OGTT）。 的 后者，166名男性和158名女性有NIDDM，237名男性和348名妇女 IGT，基于世界卫生组织的标准。 这项研究包括 生活方式和病史；人体测定法；血压;脂质和 脂蛋白测量；视力测试；视网膜照片；一个 心电图；饮食和社会心理评估；肾功能 测试； （在子集中）激素测量。 在此提案中，我们将使用尚存的1984 - 1987年参与者 通过OGTT，心血管疾病的碳水化合物耐受性的特征 （CVD），眼睛和肾脏疾病以及多种属性作为基线队列 （n = 2480）。 一些较早的数据也将用于建立稳定性 属性（例如血压，肥胖，脂质，禁食等离子体葡萄糖）。 我们建议对OGTT，CVD，眼睛和肾脏进行重复评估 疾病以及多种行为，生化和内分泌学 协变量。 这将使我们能够确定发生率和决定因素 老年人的NIDDM和IGT。 我们还将确定发病率和 在存在或不存在异常碳水化合物的情况下随着时间的流逝而死亡 宽容，并更详细地描述 基于人群的老年样本中并发症的聚类 糖尿病患者及其在横截面和前瞻性上的关系 多个内源性和外源性特征。 我们还将扩展 队列的死亡率随访时间足够长以确定是否禁食 和/或挑战后高血糖和/或高胰岛素血症是危险因素 对于所有原因和老年人的心血管死亡或临床上的心血管死亡 衰老的重要共同工资。