MAGNETIC RESONANCE STUDIES OF FOCAL FOREBRAIN ISCHEMIA

局灶性前脑缺血的磁共振研究

• 批准号: 2259709
• 负责人: JOHN A DETRE
• 金额: $ 9.33万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2259709
• 关键词: brain circulation; brain disorder chemotherapy; disease /disorder model; fibrinolytic agents; histopathology; human subject; human therapy evaluation; laboratory rat; magnetic resonance imaging; noninvasive diagnosis; nuclear medicine; prosencephalon; stroke; technology /technique

Stroke is a leading cause of morbidity and mortality in the United States and throughout the world. The purpose of the proposed research project is to characterize in vivo brain parenchymal changes in a rat model of focal stroke with reperfusion using magnetic resonance (MR) techniques. Functional assessment of the ischemic region will be carried out using a novel technique for noninvasive quantitative MR imaging of tissue perfusion, which will be used to acquire time-resolved perfusion images following acute focal stroke and subsequent reperfusion. Further characterization will be carried out using various other types of MR imaging methods which yield complementary types of tissue contrast, and comparison will be made using histopathologic analysis in the chronic stage as a "gold standard' of brain infarction and recovery. These techniques will be used to determine the MR correlates of the "ischemic penumbra", namely the regions of potentially reversible ischemia injury. Once the MR correlates are determined, the effects of various therapies aimed at reducing tissue damage in brain ischemia can be readily tested using this model. Because MR techniques are noninvasive, this approach is immediately applicable to the investigation and therapy of acute stroke in humans. For example, the accurate determination of potentially salvageable brain tissue in a patient with acute stroke would improve the risk-benefit ratio for thrombolytic therapy or other therapies which carry significant risks. To this end, technical development of the MR perfusion technique for use in humans will take place simultaneously with the rat studies.

中风是美国发病率和死亡率的主要原因 以及全世界。 拟议研究项目的目的 是为了表征体内脑脑实质在大鼠模型中的实质变化 使用磁共振（MR）技术进行再灌注的局灶性冲程。 缺血区域的功能评估将使用 一种新型的组织无创定量MR成像的技术 灌注，该灌注将用于获取时间分辨的灌注图像 急性局灶性中风和随后再灌注。 更远 将使用其他各种MR进行表征 成像方法产生互补类型的组织对比，以及 将使用慢性的组织病理学分析进行比较 阶段是大脑梗塞和恢复的“黄金标准”。 技术将用于确定“缺血性的MR​​相关性 Penumbra”，即潜在可逆性缺血损伤的区域。 一旦确定了MR相关性，各种疗法的影响 旨在减少脑缺血中的组织损伤 使用此模型。 因为MR技术是无创的，所以这种方法 立即适用于急性调查和治疗 人类中风。 例如，准确确定潜在的 急性中风患者可挽救的脑组织可改善 溶栓疗法或其他疗法的风险效益比 承担重大风险。 为此，MR的技术发展 在人类中使用的灌注技术将同时进行 大鼠研究。