POSTPRANDIAL LIPID METABOLISM IN CORONARY ARTERY DISEASE

冠状动脉疾病的餐后脂质代谢

• 批准号: 3735957
• 负责人: CHRISTOPHER J FIELDING
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3735957
• 关键词: apolipoproteins; atherosclerosis; blood lipoprotein metabolism; cardiovascular disorder diagnosis; cholesterol; chylomicrons; clearance rate; coronary disorder; dietary lipid; high density lipoproteins; human subject; hypercholesterolemia; lipid metabolism; lipoprotein disorder; low density lipoprotein; monoclonal antibody; nutrition related tag; pathologic process; retinoids; steroid metabolism; triglycerides

Fasting and postprandial lipid metabolism will be studied in the plasma of 200 men and women (50-69 years of age) with angiographically documented coronary artery disease (CAD) but with normal (<90th percentile) LDL-cholesterol and plasma triglyceride levels. The data obtained will be compared with those in a normal control group without clinical evidence of CAD, who have a negative stress test. Following a dietary challenge of whole foods supplemented with vitamin A, the removal of chylomicron apo B-48 protein will be followed postprandially, using a new monoclonal antibody method. Over the same time period, circulating levels of retinyl ester, high and low density lipoprotein (HDL and LDL) subfractions, and other metabolic factors will be assayed in order to test three different hypotheses relating to human atherogenesis, In the first, we will test whether chylomicron remnant clearance is delayed, and whether retinyl ester is a marker for apo B-48, in this group of CAD patients. In the second, we will test the hypothesis that plasma cholesterol metabolism is abnormal in CAD and in particular, that reverse cholesterol transport is reduced. In the third, we will test whether an unusual pattern of abnormal HDL and LDL subfractions, characterized by increased prebeta-HDL and/or lipid-poor LDL, is diagnostic for these patients. Together, these studies can be expected to provide new information on an important and little-studied group of men and women with CAD, and have the potential to provide important insights into the mechanism of human atherogenesis in general.

在血浆中将研究禁食和餐后脂质代谢 在200名男女（50-69岁）中 有记录的冠状动脉疾病（CAD），但正常（<90 百分比）LDL-胆固醇和血浆甘油三酸酯水平。 数据 获得的将与没有正常对照组的人进行比较 CAD的临床证据，他们的压力测试负面。 遵循 补充维生素A的全食物的饮食挑战，去除 挥舞着乳糜微粒Apo B-48蛋白将在餐后遵循 一种新的单克隆抗体法。 在同一时期，流通 视黄酯，高密度脂蛋白（HDL和LDL）的水平 将分析子侵占和其他代谢因素，以便 测试与人动脉粥样相关的三种不同的假设 首先，我们将测试是否延迟了乳糜微粒残留的清除，并且 在这组CAD中，视黄酯是否是APO B-48的标记 患者。 在第二个中，我们将测试血浆的假设 胆固醇代谢在CAD中是异常的，尤其是这种反向 胆固醇转运减少。 在第三个中，我们将测试是否 异常的HDL和LDL子部分的异常模式，其特征是 prebeta-hdl和/或脂肪贫乏的LDL增加了这些 患者。 共同期望这些研究提供新的 关于一群重要且研究的男人和女人的信息 使用CAD，并有可能对 人动脉粥样硬化的机制一般。