Cortical Hemodynamism and Oxygenation During Sleep and Cognition: Window to Cognitive Impairment and Neurodegeneration in Aging

睡眠和认知过程中的皮质血流动力学和氧合：衰老过程中认知障碍和神经退行性变的窗口

• 批准号: 10161703
• 负责人: Makoto Kawai
• 金额: $ 19.42万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10161703
• 关键词: Aging; Arousal; Biological Markers; Brain; Cerebrum; Characteristics; Cognition; Data Analyses; Dementia; Development; Development Plans; Elderly; Equation; Evaluation; Event; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Hemoglobin concentration result; Hypoxia; Impaired cognition; Intervention; Investigation; Link; Longitudinal Studies; Measures; Mediating; Medical; Medicine; Memory; Mentorship; Methodology; Methods; Modality; Modeling; Monitor; Near-Infrared Spectroscopy; Nerve Degeneration; Neurodegenerative Disorders; Neurologist; Pattern; Pharmaceutical Preparations; Physicians; Polysomnography; Prevalence; Reporting; Risk Factors; Scientist; Series; Severities; Signal Transduction; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep Disorders; Sleep Fragmentations; Sleep Stages; Slow-Wave Sleep; Structural defect; Structure; Technology; Time; Time Series Analysis; Training; age effect; age group; base; career; career development; cerebral oxygenation; cognitive development; cognitive function; cognitive performance; cognitive testing; comorbidity; executive function; improved; innovation; mild cognitive impairment; neuroimaging; new technology; normal aging; response; skills; sleep pattern; time use; tissue oxygenation

Project Summary My long-term goal is to become a leading physician-scientist in the field of “sleep medicine in aging and neurodegenerative disorders.” Specifically, I aim to become a leading expert in developing innovative methods for sleep and sleep-disordered breathing (SDB) evaluation and concomitant cognition in older adults in order to better understand neurodegenerative disorders. The proposed investigation of sleep, SDB and cognition in older adults will be the basis for my career development as a physician scientist. Sleep and SDB are under-characterized in older adults, particularly in the context of the progression from normal aging to Mild Cognitive Impairment (MCI) to dementia. This is partially because current assessments of sleep are limited due to the lack of information regarding cortical hemodynamism or oxygenation to capture sleep fragmentation or cortical hypoxia from SDB. Thus, simultaneous and synchronized recording of functional neuroimaging monitoring cortical hemodynamism and oxygenation with PSG would substantially contribute to our understanding of the effect of aging on sleep and its subsequent impact on cognitive decline and/or neurodegeneration. Newer technologies such as Near Infrared Spectroscopy (NIRS) have the potential to significantly improve the ability to acquire simultaneous synchronized recording of brain hemodynamism and oxygenation with PSG in order to better understand the aging effects on brain function during sleep and SDB. The project I propose will be to conduct simultaneous NIRS and PSG during sleep, and cognitive tests on older adults with SDB and without SDB. I aim to identify potential sleep biomarkers in hemodynamism or oxygenation patterns from SDB and sleep itself, which will form the basis for my future longitudinal study to examine the extent to which sleep architecture and associated brain function can serve as potent predictors of cognitive decline, MCI and neurodegenerative disorders. Building on my prior training as a Sleep MD and Neurologist, my career development plan is to gain the necessary additional skills to achieve this career goal. My mentorship team will guide my training in 1) combining NIRS with PSG to assess the brain function underlying sleep; 2) other modalities of functional neuroimaging; 3) analysis of functional neuroimaging technologies; 4) characterizing cognitive function, MCI and dementia; 5) understanding the pathophysiology of neurodegenerative disorders and associated comorbidities; and 6) methodological and statistical approaches to cross-sectional and longitudinal data, and analysis of medical/psychiatric comorbidities and medications that impact sleep and aging.

项目概要 我的长期目标是成为“衰老和衰老的睡眠医学”领域的医生兼科学家 “神经退行性疾病。”具体来说，我的目标是成为开发创新方法的领先专家。 用于老年人的睡眠和睡眠呼吸障碍 (SDB) 评估以及伴随认知，以便 更好地了解神经退行性疾病。拟议的睡眠、SDB 和认知研究。 老年人将成为我作为一名医师科学家职业发展的基础。 老年人的睡眠和 SDB 特征不足，特别是在疾病进展的背景下 从正常衰老到轻度认知障碍（MCI）再到痴呆，这部分是因为当前的情况。 由于缺乏有关皮质血流动力学或睡眠的信息，对睡眠的评估是有限的。 氧合以捕获 SDB 的睡眠碎片或皮质缺氧。 同步记录功能性神经影像监测皮质血流动力学和氧合 PSG 将极大地有助于我们了解衰老对睡眠及其后续影响的影响 对认知能力下降和/或神经退行性疾病的影响。 光谱学 (NIRS) 有潜力显着提高同时获取数据的能力 与 PSG 同步记录脑部血流动力学和氧合，以便更好地了解 衰老对睡眠和 SDB 期间大脑功能的影响。 我提议的项目是在睡眠期间同时进行 NIRS 和 PSG 以及认知测试 我的目标是确定患有 SDB 和未患有 SDB 的老年人的血流动力学或睡眠生物标志物。 SDB 和睡眠本身的氧合模式，这将构成我未来纵向研究的基础 检查睡眠结构和相关的大脑功能在多大程度上可以作为有效的预测因子 认知能力下降、MCI 和神经退行性疾病。 基于我之前作为睡眠医学博士和神经科医生的培训，我的职业发展计划是获得 实现这一职业目标所需的额外技能我的导师团队将在 1) 方面指导我的培训。 结合 NIRS 和 PSG 来评估睡眠背后的大脑功能 2) 其他功能模式； 神经影像；3）功能神经影像技术分析；4）表征认知功能，MCI 和痴呆；5）了解神经退行性疾病及其相关的病理生理学 合并症；和 6) 横截面和纵向数据的方法和统计方法，以及 分析影响睡眠和衰老的医学/精神合并症和药物。