DEVELOPMENT OF NEW DENTAL COMPOSITE FORMULATIONS

新型牙科复合材料配方的开发

• 批准号: 2131115
• 负责人: SID KALACHANDRA
• 金额: $ 16.65万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2131115
• 关键词: biomaterial development /preparation; biomaterial evaluation; biomechanics; composite resins; density; dental materials; fluorine; hardness; hydrogen bond; monomer; phosphates; polymers; saliva; statistics /biometry; tensile strength; viscosity; water solubility

The long range goal of this study is the development of dental composites which are less technique sensitive, wet tooth structure more readily, and have reduced curing shrinkage and water sorption. Composites have several advantages over available alternative materials: direct technique, esthetic appearance, and adhesion to tooth structure. Even so, remaining problems limit their increased use in posterior applications, where dental amalgams are still used in three-fourths of all restorations. Two major problems are stresses in the tooth created by uncompensated curing shrinkage, and the necessity of isolating current materials from moisture during placement, which requires the use of demanding and unpopular clinical procedures. The urgency of solving these problems is increased by the possibility that dental amalgam, (the only alternative direct material), may be banned because of mercury hazards. This study proposes to prepare and evaluate the series of composite materials based upon newly synthesized matrix monomers. The work is based upon the hypothesis that the problems with current materials are largely due to the quantity of diluent monomers required to control matrix viscosity, and therefore that the use of matrix monomers of lower viscosity would lead to improved properties. Recent pilot work in this laboratory has confirmed this hypothesis. Modifications of the traditional BIS-GMA monomer will be prepared, as well as two series of monomers in which the central -C(CH3)2- is replaced by groups containing phosphorous or fluorine. In each series three monomers will be prepared. One with pendant -OH group characteristic of BIS-GMA, and others with the -OH replaced by -H and -CH3. Synthesis schemes and conditions will be adjusted to avoid hydrogen bonding and oligomerization, thus minimizing viscosity. Where the viscosity of the pure monomer exceeds the viscosity characteristic of present uncured matrix materials, it will be diluted with TEGDM as needed to produce a standard viscosity. Each material will be evaluated as a monomer, as the unfilled polymer and as the matrix of a hybrid composite. The monomers will be tested for viscosity, wetting ability, water sorption and curing shrinkage. The polymers and composites will be tested for water sorption, we ability by water and saliva, and a series of physical and mechanical properties.

这项研究的长期目标是开发牙科复合材料 对技术不太敏感，更容易湿润牙齿结构，并且 减少了固化收缩和吸水性。 复合材料有 与现有替代材料相比的几个优点：直接 技术、美观以及对牙齿结构的附着力。 甚至 因此，剩下的问题限制了它们在后路应用中的增加 应用，其中四分之三的牙科汞合金仍在使用 所有修复。 两个主要问题是未补偿的牙齿产生的应力 固化收缩，以及将当前材料与 放置过程中的湿气，这需要使用苛刻和 不受欢迎的临床手术。 解决这些问题的紧迫性是 牙科汞合金（唯一的替代品）的可能性增加了 直接材料），可能因汞危害而被禁止。 本研究建议准备并评估一系列复合材料 基于新合成的基质单体的材料。 工作是 基于当前材料的问题是的假设 主要是由于控制所需稀释剂单体的数量 基体粘度，因此使用较低的基体单体 粘度将导致性能改善。 最近这方面的试点工作 实验室证实了这一假设。 的修改 将制备传统的BIS-GMA单体，以及两个系列 中心-C(CH3)2-被含有以下基团取代的单体 磷或氟。 每个系列将制备三种单体。 一种具有 BIS-GMA 的侧链 -OH 基团特征，另一些则具有 -OH被-H和-CH3取代。 合成方案和条件将 调整以避免氢键和低聚，从而最大限度地减少 粘度。 当纯单体的粘度超过粘度时 现有未固化基质材料的特性，它将被稀释 根据需要使用 TEGDM 来产生标准粘度。 每种材料都会 可以作为单体、未填充聚合物和基质进行评估 混合复合材料。 将测试单体的粘度、润湿性 能力、吸水性和固化收缩率。 聚合物和 将测试复合材料的吸水性，我们通过水和 唾液等一系列物理机械性能。