PROPERTIES OF NOCICEPTORS OF THE TEMPOROMANDIBULAR JOINT

颞下颌关节伤害感受器的特性

• 批准号: 2131015
• 负责人: BRIAN Y COOPER
• 金额: $ 12.55万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2131015
• 关键词: analgesics; bradykinin; ganglions; gender difference; goats; innervation; interleukin 1; jaw movement; leukotrienes; neuroimmunomodulation; neuropharmacology; neurophysiology; pain; sensory receptors; serotonin; synovial fluid; temporomandibular joint; trigeminal nerve

Each year, thousands seek treatment for pain in the temporomandibular joint (TMJ). The cost, both in human suffering and health care resources, is enormous. The goal of this proposal is to establish an animal preparation for the study of TMJ nociceptor physiology. The lack of a physiological model of TMJ joint nociception prevents effective testing of current hypotheses of the etiology of TMJ pain, and limits development and testing of new analgesics. Our initial project focuses on identifying the characteristics and distribution of TMJ nociceptors. Extracellular, single unit recording techniques will be used to characterize the activity of cell bodies of TMJ afferents in the trigeminal ganglion in response to controlled movements of the mandible. The second project attempts to identify the endogenous agents that may be directly involved in the production and maintenance of TMJ pain through their ability to activate and sensitize nociceptors. Other models of joint nociception (cat knee joint) have concentrated on prostaglandin mediated mechanisms of sensitization. Due to the relatively weak affects of aspirin-like drugs, we will concentrate on the affects of non-prostaglandin factors. These will include substances such as interleukin-1, leukotriene B4 and serotonin. These substances have been found in high concentrations in the synovial fluid of painful joints. Through the identification of factors contributing to joint nociceptor activation and sensitization we hope to identify the type of compounds likely to have analgesic activity in the chronically painful TMJ. Contained within the body of these two studies is a comparison of properties of nociceptors in males and females. TMJ pain is reported disproportionately in the female population. A determination of physiological similarities and disimilarities, including receptor distributions, range and propensity to sensitize may clarify etiology and treatment of this gender based disorder.

每年，成千上万的颞下颌疼痛治疗 关节（TMJ）。在人类痛苦和医疗保健资源中的成本， 是巨大的。该提议的目的是建立动物 用于研究TMJ伤害感受器生理的准备。缺乏 TMJ关节伤害感受的生理模型可防止有效测试 当前的TMJ疼痛病因的假设，并限制了发展 并测试新的镇痛药。我们最初的项目着重于确定 TMJ伤害感受器的特征和分布。 细胞外， 单个单元记录技术将用于表征 TMJ传入的细胞体在三叉神经节中的活性 对下颌骨受控运动的响应。第二个项目 试图识别可能直接涉及的内源性剂 在TMJ疼痛的生产和维护中，他们的能力 激活并使伤害感受器敏感。 其他关节伤害感受 （猫膝关节）集中于前列腺素介导的机制 敏化。 由于阿司匹林样的影响相对较弱 药物，我们将集中精力于非局部因素的影响。 这些将包括白介素-1，白三烯B4和 5-羟色胺。这些物质在高浓度中发现 疼痛关节的滑液。通过识别因素 有助于关节伤害感受器的激活和敏化，我们希望 确定在该化合物中可能具有镇痛活性的化合物类型 长期痛苦的TMJ。包含这两个研究的身体 是男性和女性伤害感受器的性质的比较。 TMJ 女性人群的疼痛不成比例。 一个 确定生理相似性和灾难性，包括 受体分布，范围和敏感性可能会澄清 这种基于性别的疾病的病因和治疗。