LONG-TERM POTENTIATION IN OLFACTORY CORTEX

嗅觉皮层的长期增强

• 批准号: 2127533
• 负责人: JEFFREY S STRIPLING
• 金额: $ 15.17万
• 依托单位: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2127533
• 关键词: NMDA receptors; brain electrical activity; central neural pathway /tract; evoked potentials; hippocampus; laboratory rat; long term potentiation; neural information processing; neural plasticity; neural transmission; olfactions; olfactory lobe; single cell analysis

The objective of the proposed research is the analysis of a novel form of long-term potentiation recently discovered in olfactory cortex. This potentiation is induced by repeated high-frequency stimulation of the olfactory bulb or of association fibers in olfactory cortex, and is manifested as a selective long-term potentiation of late components in potentials evoked in the olfactory cortex and olfactory bulb. Previous research indicates that this potentiation is very long-lasting and is dependent upon activation of NMDA receptors for its induction. Evaluation of available evidence supports the hypothesis that this potentiation reflects enhanced transmission at the synapses made by cortical association fibers upon inhibitory neurons in the olfactory cortex and olfactory bulb. The proposed research will explore the functional significance of this potentiation and test the hypothesis outlined above using evoked potential and single-cell recording techniques and a current source-density analysis in freely-moving and urethane-anesthetized rats. These techniques will be used to address the following issues: a) the identity of the specific synapses that undergo potentiation; b) the effect of this potentiation on the response of principal neurons in the olfactory cortex and olfactory bulb to activation of afferent and cortical association fibers, c) the relationship of this potentiation to other forms of functional plasticity known to occur in olfactory cortex, and d) the circumstances under which this potentiation is most likely to occur naturally. The outcome of this research should provide insight into how synapses in the olfactory cortex and olfactory bulb are modified by experience and how this modification affects patterns of activity within these two areas and interactions between them. This in turn should aid in understanding the mechanisms of information processing, storage, and retrieval in the olfactory forebrain and, by extension, contribute to the understanding and eventual treatment of olfactory disorders.

拟议研究的目的是分析一种新型形式 最近在嗅觉皮层中发现的长期增强。这 通过反复的高频刺激来诱导增强 嗅球或嗅觉皮质中的嗅球纤维，IS 表现为对后期组件的选择性长期增强 在嗅觉皮层和嗅球中引起的电势。以前的 研究表明，这种增强非常持久，并且是 取决于NMDA受体的诱导激活。评估 可用的证据支持了这种增强的假设 反映了皮质制成的突触时的增强的传播 嗅觉皮质中抑制性神经元的关联纤维和 嗅球。 拟议的研究将探讨这一点的功能意义 增强和测试了上述使用诱发潜力的假设 和单细胞记录技术和当前的源密度分析 在自由移动和氨基甲酸酯麻醉的大鼠中。这些技术将是 用于解决以下问题：a）特定的身份 进行增强的突触； b）这种增强作用对 主要神经元在嗅觉和嗅觉中的反应 灯泡激活传入和皮质关联纤维，c） 这种增强与其他形式的功能可塑性的关系 已知发生在嗅皮层中，d） 这种增强最有可能自然发生。结果的结果 研究应提供有关如何在嗅觉皮层中突触的洞察力 和嗅球通过经验以及这种修改如何修改 影响这两个领域的活动模式和互动 他们之间。反过来，这应该有助于理解 嗅觉前脑中的信息处理，存储和检索 而且，扩展有助于理解和最终治疗 嗅觉疾病。