EQUALIZED DUAL ENERGY/DUAL PHOSPHOR CHEST RADIOGRAPHY

均衡双能量/双荧光胸片

基本信息

批准号：
2096587
负责人：
JOHN M BOONE
金额：
$ 12.57万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
起止时间：
1991-08-01 至 1995-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2096587
关键词：
biomedical equipment development cardiography charge coupled device camera clinical biomedical equipment computer simulation digital imaging energy source gadolinium image processing phantom model phosphorescence radionuclides respiratory imaging /visualization scintillation cameras yttrium

项目摘要

This proposal addresses the marriage of two novel technologies, with the overall objective to develop a practical single- and dual-energy digital radiography system, dedicated and optimized for chest imaging. A filter wheel equalization system compensates for over- and under-penetrated areas in the image, by reducing or increasing the entrance exposure to those areas. A series of computer controlled wheels are mounted near the x-ray tube, and the filter wheels have organ-specific compensation patterns, determined by analysis of numerous chest images, machined into them. A low-dose prescan image is acquired with only homogeneous-filtration present, and based on analysis of the prescan image the computer automatically rotates the most appropriate filter wheel patterns into position to achieve compensation and the radiographic exposure is acquired. The heart, left lung and right lung are the principle thoracic features which demand enormous detector latitude; independent compensation of these structures will reduce the exposure dynamic range and will yield better uniformity in the signal-to-noise performance of the system. This will improve the detectability of pulmo- nary nodules since detectability is fundamentally related to the signal to noise ratio. The proposed detector is a novel dual phosphor (binary) screen system, composed of two phosphors differing in energy-dependent x-ray absorption (different k-edges), but also differing in their optical emission properties. One phosphor (Gd2O2S:Eu, k-edge = 50 keV) emits principally at 624 nm, and the other (y2O3:Gd, k-edge = 17 keV) emits at 315 nm. Using optical filtration, dual CCD cameras are individually tuned to the optical emission spectrum of each phosphor, thereby allowing the low energy and high energy images to be acquired simultaneously during one x-ray pulse. The marriage of the filter wheel equalization system with the binary screen detector will result in a synergistic and comprehensive approach to chest radiography. The research methodology includes the acquisition of a large data base of chest images (digitized from film) to facilitate a statistical approach to the compensation pattern design and analysis, computer simulation and design optimization of both the compensation and detector subsystems, construction and testing of a prototype system including image performance characterization (MTF & DQE), and ROC analysis of experimentally acquired images. The comprehensive approach to digital chest imaging proposed here should increase the effectiveness of chest radiography, by increasing the sensitivity and specificity to pulmonary nodules and other chest pathologies.

该提议解决了两种新技术的婚姻，开发实用的单能数字的总体目标 X射线照相系统，专用于胸部成像。过滤器车轮均衡系统补偿了过度和不足的图像中的区域，通过减少或增加入口暴露那些地区。一系列计算机控制的轮子安装在附近 X射线管，滤轮轮具有特定器官的补偿通过分析众多胸部图像确定的模式，被加工到他们。仅使用存在均匀滤波，并基于对Prescan的分析图像计算机自动旋转最合适的过滤器车轮图案到位以获得补偿和射线照相获取曝光。心脏，左肺和右肺是胸腔特征需要巨大的检测器纬度；这些结构的独立补偿将减少暴露动态范围，将在信噪比中产生更好的均匀性系统的性能。这将提高pulmo-的可检测性 nary结节，因为可检测性与信号从根本上相关与噪声比。提出的检测器是一种新型的双磷光器（二元）屏幕系统，由两个磷酸盐组成，依赖能量 X射线吸收（不同的K-Edges），但其光学也有所不同排放特性。一个磷（GD2O2S：欧盟，k-edge = 50 kev）发出主要在624 nm，另一个（y2o3：gd，k-edge = 17 keV）发出 315 nm。使用光学过滤，双CCD摄像机是单独的调谐到每个磷光器的光学发射光谱，从而允许低能和高能量图像同时获得在一个X射线脉冲中。滤轮均衡的婚姻带有二进制屏幕检测器的系统将导致协同作用和胸部射线照相的全面方法。研究方法包括获取大型胸部图像数据库（数字化从电影中）促进补偿的统计方法模式设计和分析，计算机模拟和设计优化补偿和探测器子系统，建筑和测试原型系统，包括图像性能表征（MTF和DQE）和实验获得的ROC分析图像。提出的数字胸部成像的全面方法这里应通过提高对肺结节和其他的敏感性和特异性胸部病理。