DNA DAMAGE /MUTATION IN P53--ROLE IN CELL TRANSFORMATION

P53 DNA 损伤/突变——在细胞转化中的作用

• 批准号: 2086940
• 负责人: VERONICA M MAHER
• 金额: $ 18.79万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2086940
• 关键词: DNA; DAMAGE; MUTATION; P53; ROLE

项目成果

Comparing the frequency and spectra of mutations induced when an SV-40 based shuttle vector containing covalently bound residues of structurally-related carcinogens replicates in human cells.

比较含有结构相关致癌物共价结合残基的基于 SV-40 的穿梭载体在人体细胞中复制时诱导的突变频率和谱。

• DOI: 10.1016/0165-1110(89)90013-4
• 发表时间: 1989
• 期刊: Mutation research
• 作者: Maher,VM;Yang,JL;Mah,MC;McCormick,JJ
• 通讯作者: McCormick,JJ

Amplification and direct nucleotide sequencing of cDNA from the lysate of low numbers of diploid human cells.

对少量二倍体人类细胞裂解物中的 cDNA 进行扩增和直接核苷酸测序。

• DOI: 10.1016/0378-1119(89)90121-2
• 发表时间: 1989
• 期刊: Gene
• 影响因子: 3.5
• 作者: Yang,JL;Maher,VM;McCormick,JJ
• 通讯作者: McCormick,JJ

A quantitative assay for measuring the induction of mutations in human peripheral blood T-lymphocytes.

用于测量人外周血 T 淋巴细胞突变诱导的定量测定。

• DOI: 10.1016/0027-5107(90)90047-8
• 发表时间: 1990
• 期刊: Mutation research
• 作者: Norimura,T;Maher,VM;McCormick,JJ
• 通讯作者: McCormick,JJ

Amplification of mRNA of the hprt gene from lysates of mutant human cells and direct DNA sequencing to determine the spectrum of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha, epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

从突变人类细胞裂解物中扩增 hprt 基因的 mRNA，并直接进行 DNA 测序，以确定 (l-)-7 beta,8 alpha-二羟基-9 alpha,10 alpha,环氧-7,8,

• 发表时间: 1990
• 期刊: Progress in clinical and biological research
• 作者: Maher,VM;Yang,JL;McCormick,JJ
• 通讯作者: McCormick,JJ

Kinds and location of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts.

次黄嘌呤（鸟嘌呤）编码区（I-）-7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并[a]芘诱导突变的种类和位置

• DOI: 10.1093/carcin/12.1.71
• 发表时间: 1991
• 期刊: Carcinogenesis
• 影响因子: 4.7
• 作者: Yang,JL;Chen,RH;Maher,VM;McCormick,JJ
• 通讯作者: McCormick,JJ