Regulation of Cellular Behavior in Response to Extracellular Cues

响应细胞外信号的细胞行为调节

• 批准号: 10557022
• 负责人: Clarissa A Henry
• 金额: $ 246.11万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-05 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557022
• 关键词: APLN gene; Acceleration; Autophagocytosis; Biological; Biomedical Engineering; Biomedical Research; Cell Signaling Process; Cells; Centers of Research Excellence; Communicable Diseases; Complement; Core Facility; Cues; Cultured Cells; Development; Disease; Doctor' s Degree; Engineering; Environment; Facility Designs; Faculty; Funding; Future; G Protein-Coupled Receptor Signaling; G-Protein-Coupled Receptors; Goals; Grant; Homeostasis; Image; Image Analysis; Industry; Influenza; Institution; Investments; Island; Laboratories; Leadership; Lytic; Maine; Medical center; Mentors; Mentorship; Microscopy; Modeling; Muscle; Muscle Cells; Myopathy; Natural regeneration; Neuromuscular Diseases; New England; Positioning Attribute; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Running; Science; Senior Scientist; Signal Transduction; Students; The Jackson Laboratory; Training; United States National Institutes of Health; Universities; Virus; Virus Diseases; Yeasts; Zebrafish; career; cell behavior; cell growth regulation; cell motility; cell type; experience; extracellular; graduate school; graduate student; imaging facilities; infectious disease treatment; innate immune function; meetings; migration; muscle aging; muscle regeneration; programs; recruit; response; success; teaching laboratory; virus infection mechanism

OVERALL ABSTRACT The long-term goal of this Center for Biomedical Research Excellence (COBRE) is to help grow the burgeoning biomedical research industry in Maine by positioning the University of Maine (UMaine) as a biomedical research and training hub that supports and recruits outstanding junior faculty while strengthening our unique statewide graduate program. This COBRE is focused on Regulation of Cellular Behavior in Response to Extracellular Cues. All cells interpret and respond to their environment, yet the mechanisms by which cells process signaling inputs and parse them into discrete cell behaviors are not fully understood. How does G protein coupled receptor signaling regulate polarity in different cell types? How does the extracellular environment regulate muscle cell behaviors such as migration and regeneration? How do viruses modify cells to cause disease? Five research projects led by early career investigators from UMaine and Mount Desert Island Biological Laboratory (MDIBL) will address cell-microenvironmental signaling across three contexts : mechanisms of viral infection in cultured cells and zebrafish; gradient tracking in yeast, and mechanisms of muscle homeostasis in zebrafish. The five research projects are: Cellular reprogramming in Persistent versus Lytic JC Viral Infections (Maginnis); Motility and Guidance Signals Control Migration of Muscle Precursors (Talbot); Mechanisms of GPCR-induced Autophagy (Kelley); Apelin Signaling in Muscle Regeneration (Madeleine), and Innate Immune Function in Influenza-Associated Myopathy (King). Each project leverages the unique expertise of research project leaders while advancing the theme of extracellular impacts on cell behavior. Projects exploit existing IDeA resources and the proposed new core facility in Microscopy and Image Analysis. This COBRE further enhances partnerships among biomedical research institutions in Maine. As director of a state-wide graduate program with 54 graduate students and >150 faculty, Dr. Henry has the leadership experience to guide this COBRE. This COBRE will accelerate the careers of our Junior Investigators by adding: external senior scientists as mentors, state-of-the art live imaging, image analytics, and an expanded zebrafish facility to strengthen the biomedical research infrastructure. UMaine is the only institution in the state that grants doctoral degrees in biomedical science and biomedical engineering. This COBRE, which will be UMaine’s first, will transform UMaine’s ability to serve as the academic leader for biomedical research in Maine and feed the growing biomedical research industry in Maine. This research will elucidate basic biological mechanisms underlying cell behavior, and also has the potential to inform future treatment of infectious diseases, neuromuscular disorders, and muscle aging and regeneration.

总体摘要 该生物医学卓越研究中心 (COBRE) 的长期目标是帮助发展 通过将缅因大学（UMaine）定位为缅因州蓬勃发展的生物医学研究产业 生物医学研究和培训中心，支持和招聘优秀的初级教师，同时加强 我们独特的联邦研究生项目专注于细胞行为的调节。 对细胞外信号的反应 所有细胞都会对其环境做出解释和反应，但其机制是通过 哪些细胞处理信号输入并将其解析为离散的细胞行为尚不完全清楚。 G蛋白偶联受体信号传导如何调节不同细胞类型的极性？ 环境调节肌肉细胞的行为，例如迁移和再生？病毒如何改变细胞？ 引起疾病？由来自缅因州和沙漠山的早期职业研究人员领导的五个研究项目 Island Biological Laboratory (MDIBL) 将解决三个背景下的细胞微环境信号传导问题： 培养细胞和斑马鱼中的病毒感染机制；酵母中的梯度追踪及其机制 斑马鱼的肌肉稳态这五个研究项目是： 持久性与细胞重编程。 裂解性 JC 病毒感染（Maginnis）；运动性和引导信号控制肌肉前体的迁移 (Talbot)；GPCR 诱导的自噬机制 (Kelley)； （马德琳）和流感相关肌病的先天免疫功能（金）。 每个项目都利用研究项目领导者的独特专业知识，同时推进以下主题： 细胞外对细胞行为的影响。项目利用现有的 IDeA 资源和拟议的新核心。 该 COBRE 进一步加强了生物医学领域的合作伙伴关系。 作为缅因州研究生项目的主任，该项目拥有 54 名研究生， > 150 名教职员工，亨利博士拥有指导该 COBRE 的领导经验，该 COBRE 将加速该项目的发展。 我们的初级研究人员的职业生涯增加了：外部资深科学家作为导师，最先进的现场直播 成像、图像分析和扩大的斑马鱼设施以加强生物医学研究 基础设施。 缅因大学是该州唯一授予生物医学博士学位的机构 这将是缅因大学的第一个生物医学工程项目，它将改变缅因大学作为生物医学工程的能力。 缅因州生物医学研究的学术领导者，并为缅因州不断增长的生物医学研究行业提供支持 缅因州。这项研究将阐明细胞行为的基本生物学机制，并且还具有 为传染病、神经肌肉疾病和肌肉衰老的未来治疗提供信息的潜力 再生。