Training in Advanced Heart Disease Research

高级心脏病研究培训

基本信息

批准号：
10556039
负责人：
Joshua I Goldhaber
金额：
$ 54.02万
依托单位：
CEDARS-SINAI MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10556039
关键词：
Heart Diseases Research Training

项目摘要

The Smidt Heart Institute (SHI) at Cedars-Sinai Medical Center (CSMC) is applying for the second competitive renewal of its postdoctoral Advanced Heart Disease Research Training Program. The objective of this program is to provide outstanding team-mentored training in either basic biomedical, translational or health services research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide trainees with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology, and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the-art investigations in the laboratory. Our training program’s areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women’s Health, Community Health, Implementation Science, Precision Medicine, Artificial Intelligence, Proteomics, and Genetics. The Training Program takes full advantage of the unique strengths of CSMC, the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The SHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Advanced Clinical Biosystems Institute and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, biostatistics, methodology, and ethics. Courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles R. Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, methodology and biostatistics, UCLA degree programs in public health and clinical research, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.

Cedars-Sinai 医疗中心 (CSMC) 的 Smidt 心脏研究所 (SHI) 正在申请第二次竞争性更新其博士后高级心脏病研究培训计划该计划的目标。是在基本生物医学、转化或健康服务方面提供出色的团队指导培训六名博士后研究员的研究（每年 3 名 x 2 年）。我们力求确保培养心血管科学领域独立且富有成效的学术职业的技能。我们所有的学员，无论是博士、医学博士、医学博士/博士或同等学历，都能深入了解基础知识支持心血管医学临床相关问题的科学，以及全面的了解严格的研究设计、适当的方法以及基础和基础研究的专家技术执行这不仅为临床研究人员提供了正确检验假设所需的技能。产生于基础科学层面，同时也让基础科学家了解疾病的临床方面为了促进实验室中临床相关的最先进的研究。研究重点包括心脏生物学、心律失常、血管生物学和动脉粥样硬化、再生医学、移植免疫学、心血管影像、妇女健康、社区健康、实施科学、精准医学、人工智能、蛋白质组学和遗传学。项目充分利用了西部最大的私立教学医院华润医疗的独特优势密西西比州长期致力于转化研究和服务当地社区。 SHI 拥有世界上最大的成人心脏移植项目，并进行了 NIH 资助的首次人体心脏移植手术心脏来源干细胞疗法的试验，吸引了许多 NIH 资助的基础和转化研究其中一些人在其他 CSMC 部门共同任职，其中包括再生部门。医学研究所、生物医学影像研究所、先进临床生物系统研究所和生物医学科学、医学和病理学系的学员接受深入的研究。在重点研究领域的经验，并通过包括基础和临床研讨会、拨款和稿件写作指导、生物统计学、方法论和伦理学课程。由生物医学系、华润医学临床学者计划和多校区提供 NIH CTSA 支持的转化科学研究中心 (CTSI，包括 CSMC、UCLA、Harbor-UCLA、 CTSI 为我们的学员提供获得项目种子资金的特权，临床研究设计、方法论和生物统计学、加州大学洛杉矶分校公共学位课程的附加课程健康和临床研究，以及进行从实验室到临床到整个研究范围的工具总之，我们设计了一个计划，在关键领域提供深入的培训。在支持转化研究和临床卓越的环境中进行心血管科学。

项目成果

期刊论文数量（57）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.

DOI：
10.1080/15548627.2015.1115172
发表时间：
2016
期刊：
Autophagy
影响因子：
13.3
作者：
Sin J;Andres AM;Taylor DJ;Weston T;Hiraumi Y;Stotland A;Kim BJ;Huang C;Doran KS;Gottlieb RA
通讯作者：
Gottlieb RA

Mechanical Circulatory Support in Right Ventricular Failure.

DOI：
10.1016/j.iccl.2020.12.010
发表时间：
2021-04-01
期刊：
Interventional cardiology clinics
影响因子：
0
作者：
Akhmerov, Akbarshakh;Ramzy, Danny
通讯作者：
Ramzy, Danny

The accuracy of coronary CT angiography in patients with coronary calcium score above 1000 Agatston Units: Comparison with quantitative coronary angiography.

DOI：
10.1016/j.jcct.2021.03.007
发表时间：
2021-09
期刊：
Journal of cardiovascular computed tomography
影响因子：
5.4
作者：
Kwan AC;Gransar H;Tzolos E;Chen B;Otaki Y;Klein E;Pope AJ;Han D;Howarth A;Jain N;Dey D;Miller RJ;Cheng V;Azarbal B;Berman DS
通讯作者：
Berman DS

Socioeconomic disparities in midterm outcomes after repair for degenerative mitral regurgitation.

退行性二尖瓣反流修复后中期结果的社会经济差异。

DOI：
10.1016/j.jtcvs.2023.05.045
发表时间：
2023
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
0
作者：
Malas,Jad;Chen,Qiudong;Emerson,Dominic;Gill,George;Rowe,Georgina;Egorova,Natalia;Trento,Alfredo;Chikwe,Joanna;Bowdish,MichaelE
通讯作者：
Bowdish,MichaelE

Reversal of right ventricular pressure loading improves function independent of fibrosis.

右心室压力负荷的逆转可改善功能，而与纤维化无关。