The Effect of Progressive Muscle Relaxation with Music for Nausea and Vomiting Related to Chemotherapy : in Concerning about Anxiety, Age, and Natural Killer Cell Activity

音乐渐进式肌肉放松对化疗相关恶心和呕吐的影响：关于焦虑、年龄和自然杀伤细胞活性

基本信息

批准号：
09672388
负责人：
ONISHI Kazuko
金额：
$ 1.73万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

This study was to examine about 1) the effect of progressive muscle relaxation (PMR) with music therapy (M), 2) the relationships among nausea/vomiting/retching (NVR), age, and anxiety, 3) the relationship between NVR and each cycle, and 4) the change of natural killer cell activity (Nkact), white blood cell, growth hormone, and others in using PMR with M.Subjects are 35 hospitalized cancer patients having chemotherapy (experimental group : 20, control group : 15) at M University hospital and two general hospitals. The average age was 54.3 years old.The result showed the trend of the effectiveness of PMR with M, although it was not statistically significant. The scores of NVR were 2.313 for the experimental group and 3.466 for the control group. But the patients at the university hospital had the effectiveness of PMR with M (p<.05). The average age of the patients at the university hospital was 10 years younger than the patients at two hospitals. And the relationship between NVR and age showed that the younger patients had severer NVR than the older patients (r=-.534). Thus, the younger patients may have severer NVR and get more effect of PMR than the older patients.There was not statistically significance for the relationship between NVR and anxiety. But the patients at the university showed that the severer NVR was, the stronger anxiety (state) was (r=.68). And Cycle 1 showed more scores of NVR than cycle 2 and cycle 3. Thus, it is important for nurse to help the patients not to experience sever NVR at cycle 1 and also not to have strong anxiety.The change of Nkact, white blood cell, growth hormone, and others in using PMR with M has not been shown here because there were not enough data to analyze. Therefore, this study has been continuing.

本研究旨在检验 1) 渐进性肌肉放松 (PMR) 与音乐疗法 (M) 的效果，2) 恶心/呕吐/干呕 (NVR)、年龄和焦虑之间的关系，3) NVR 与每个周期，以及4）自然杀伤细胞活性（Nkact）、白细胞、生长激素等在使用PMR与M时的变化。受试者为35名正在接受化疗的住院癌症患者（实验组： 20、对照组：15）在M大学医院和两家综合医院。平均年龄为54.3岁。结果显示了PMR与M的有效性趋势，但没有统计学意义。实验组NVR得分为2.313，对照组为3.466。但大学医院的患者 PMR 具有 M 的有效性 (p<.05)。大学医院的患者平均年龄比两家医院的患者年轻10岁。 NVR与年龄的关系显示，年轻患者的NVR较老年患者严重（r=-.534）。因此，年轻患者可能比老年患者有更严重的NVR，并且获得更多的PMR效果。NVR与焦虑之间的关系没有统计学意义。但大学的患者表明，NVR 越严重，焦虑（状态）越强（r=.68）。并且第1周期的NVR评分高于第2周期和第3周期。因此，护士必须帮助患者在第1周期不要经历严重的NVR并且不要有强烈的焦虑。Nkact、白细胞的变化、生长激素和其他与 M 一起使用 PMR 的方法此处未显示，因为没有足够的数据可供分析。因此，这项研究一直在持续进行。