Patient-oriented research and mentoring in preterm birth toxicogenomics

以患者为中心的早产毒理基因组学研究和指导

• 批准号: 10542363
• 负责人: TRACY A. MANUCK
• 金额: $ 16.36万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10542363
• 关键词: Address; Advisory Committees; Air Pollution; Award; Biological Assay; Biological Markers; Biological Monitoring; Biometry; Caring; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Complement; Complex; Complex Mixtures; Data; Diabetes Mellitus; Diet; Dimensions; Educational workshop; Effectiveness; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Epigenetic Process; Exposure to; Faculty; Fellowship; Fetal Growth Retardation; Funding; Future; Gene Expression; Genetic; Genotype; Goals; Grant; Health; High Risk Woman; Home; Human; Inflammation; Inflammatory; Knowledge; Leadership; Maternal Messenger RNA; Maternal-fetal medicine; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Mission; Monitor; Mutation; National Institute of Environmental Health Sciences; Neonatology; Nitric Oxide Pathway; North Carolina; Patient Self-Report; Pharmacogenomics; Phase; Physicians; Placenta; Play; Postdoctoral Fellow; Pregnancy; Pregnant Women; Premature Birth; Prevention therapy; Progesterone; Recruitment Activity; Recurrence; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Risk Reduction; Role; Scientist; Serum; Statistical Methods; Surveys; Survivors; Testing; Time; Toxic Environmental Substances; Toxicogenomics; Training; Training Programs; Translational Research; United States National Institutes of Health; Urine; Woman; Work; Writing; career; career development; cohort; disability; drinking water; early pregnancy; gene environment interaction; global health; high risk; improved; indexing; instructor; metal metabolism; mortality; multidimensional data; multidisciplinary; neonate; next generation; patient oriented research; premature; prevent; prospective; psychosocial; racial disparity; recruit; relapse prevention; response; skills; social; toxicant; training opportunity; Address; Advisory Committees; Air Pollution; Award; Biological Assay; Biological Markers; Biological Monitoring; Biometry; Caring; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Complement; Complex; Complex Mixtures; Data; Diabetes Mellitus; Diet; Dimensions; Educational workshop; Effectiveness; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Epigenetic Process; Exposure to; Faculty; Fellowship; Fetal Growth Retardation; Funding; Future; Gene Expression; Genetic; Genotype; Goals; Grant; Health; High Risk Woman; Home; Human; Inflammation; Inflammatory; Knowledge; Leadership; Maternal Messenger RNA; Maternal-fetal medicine; Measures; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Mission; Monitor; Mutation; National Institute of Environmental Health Sciences; Neonatology; Nitric Oxide Pathway; North Carolina; Patient Self-Report; Pharmacogenomics; Phase; Physicians; Placenta; Play; Postdoctoral Fellow; Pregnancy; Pregnant Women; Premature Birth; Prevention therapy; Progesterone; Recruitment Activity; Recurrence; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Risk Reduction; Role; Scientist; Serum; Statistical Methods; Surveys; Survivors; Testing; Time; Toxic Environmental Substances; Toxicogenomics; Training; Training Programs; Translational Research; United States National Institutes of Health; Urine; Woman; Work; Writing; career; career development; cohort; disability; drinking water; early pregnancy; gene environment interaction; global health; high risk; improved; indexing; instructor; metal metabolism; mortality; multidimensional data; multidisciplinary; neonate; next generation; patient oriented research; premature; prevent; prospective; psychosocial; racial disparity; recruit; relapse prevention; response; skills; social; toxicant; training opportunity

PROJECT SUMMARY This K24 proposal builds on over a decade of clinical and translational research – which the candidate – Dr. Tracy Manuck, MD, MSc, has focused on spontaneous preterm birth (SPTB). In this application, Dr. Manuck has recruited a team of multidisciplinary faculty experts to collaborate and support her in this endeavor, one that reflects the breadth and depth of UNC’s resources in environmental research. This work will greatly augment her current portfolio in patient-oriented research, allowing her to expand her current work and incorporate environmental contaminants into her current R01 funded study (R01-MD011609), creating a rich, multi- dimensional dataset. Candidate: Dr. Manuck is a recognized thought leader in the pharmacogenomics of SPTB. She has won numerous national accolades and has led high-impact clinical prematurity studies; here, she seeks to complement these skills by incorporating toxicogenomics into her research. Mentoring Plan/Environment: Dr. Manuck has an established track record in research training, including serving as Maternal Fetal Medicine (MFM) fellowship research director and a small group instructor for 2 graduate-level grant writing courses for fellows and junior faculty. However, competing administrative and clinical responsibilities limit her available time for mentorship. K24 award support will enable a more comprehensive mentoring portfolio within prematurity, and help to develop the critical mass of researchers investigating reproductive health effects of environmental contaminant exposure that is urgently needed in this field. With K24 support, she will have the appropriate time and resources to mentor advanced trainees (e.g., postdoctoral fellows, junior faculty) in their pursuit of independent funding. Dr. Manuck will leverage UNC’s extensive resources to accomplish this goal, including NIH-funded centers and training programs, networks and collaborations, and global health institutes. Career Goals and Objectives: Dr. Manuck will accomplish the following career development aims, including: Career Aim 1 - Expand knowledge of environmental health; Career Aim 2 - Improve mentorship skills; Career Aim 3 - Strengthen the ability to disseminate scientific results. Research Plan: Dr. Manuck will leverage her R01 study (currently recruiting) to evaluate the effects of exposure to pro-inflammatory environmental contaminants as an additional key driver of SPTB. She will integrate mentorship across the research aims: Aim 1 – Quantify exposure to environmental contaminants during pregnancy through self-report and biomonitoring of maternal urine, serum, and placentas; Aim 2 – Determine which contaminant or combination of contaminants is most strongly associated with SPTB; and Aim 3 – Test the effects of gene x environment interactions on recurrent SPTB risk. This plan offers a framework for Dr. Manuck’s training in the incorporation of environmental contaminants into prematurity studies, with potential for lifelong impact on the >450,000 babies delivered too soon in the US each year, while simultaneously providing a platform for mentoring future investigators committed to patient-oriented research.

项目摘要 这项K24提案建立在十多年的临床和翻译研究的基础上 - 候选人 - 博士。 医学博士的Tracy Manuck专注于赞助早产（SPTB）。在此申请中，Manuck博士有 招募了一支由多学科教师专家组成的团队，以在这项工作中进行合作和支持她，这是一个 反映了UNC在环境研究中资源的广度和深度。这项工作将大大增加她 当前的以患者为导向研究的投资组合，使她能够扩大当前的作品并合并 她当前的R01资助研究（R01-MD011609）中的环境污染物，创造了丰富的多种多样的 维数据集。候选人：Manuck博士是SPTB药物基因组学的公认思想领导者。 她赢得了许多国家荣誉，并领导了高影响力的临床早产研究。她在这里寻求 通过将毒物组学纳入她的研究来补充这些技能。指导计划/环境： 玛雅克博士在研究培训方面有着既定的记录，包括担任孕产妇医学 （MFM）奖学金研究总监和一位小组教练，用于2个研究生级赠款写作课程 研究员和初级教师。但是，竞争的行政和临床职责限制了她的可用时间 进行训练。 K24奖励支持将使更全面的心理投资组合在早产中，并且 帮助发展研究环境生殖健康影响的临界研究人员 在该领域迫切需要的污染物暴露。在K24的支持下，她将有适当的时间 和精神高级学员的资源（例如，博士后研究员，初级教师）追求 独立资金。玛雅克博士将利用UNC的大量资源来实现这一目标，包括 NIH资助的中心和培训计划，网络和合作以及全球卫生机构。职业 目标和目标：Manuck博士将完成以下职业发展目标，包括：职业 目标1-扩大对环境健康的了解；职业目标2-改进技能；职业目标3- 增强传播科学结果的能力。研究计划：Manuck博士将利用她的R01研究 （目前招募）评估暴露于促炎环境污染物的影响 SPTB的其他关键驱动力。她将在整个研究目标中整合Mentalship：AIM 1 - 量化暴露 通过自我报告和孕产妇尿液，血清，血清的生物监测到怀孕期间的环境污染物 和lopetas;目标2 - 确定污染物的污染物或组合最密切相关 与SPTB； AIM 3 - 测试基因X环境相互作用对复发SPTB风险的影响。这个计划 为Manuck博士在环境污染物公司培训过早的培训提供了一个框架 研究，每年在美国分娩的> 450,000名婴儿的终身影响，而 同样，为致力于患者研究的心理研究人员提供了一个平台。