Patient-oriented research and mentoring in preterm birth toxicogenomics

以患者为中心的早产毒理基因组学研究和指导

基本信息

批准号：
10542363
负责人：
TRACY A. MANUCK
金额：
$ 16.36万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-15 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10542363
关键词：
Address Advisory Committees Air Pollution Award Biological Assay Biological Markers Biological Monitoring Biometry Caring Chemicals Clinical Clinical Research Collaborations Communities Complement Complex Complex Mixtures Data Diabetes Mellitus Diet Dimensions Educational workshop Effectiveness Environment Environmental Exposure Environmental Health Environmental Impact Environmental Pollutants Epigenetic Process Exposure to Faculty Fellowship Fetal Growth Retardation Funding Future Gene Expression Genetic Genotype Goals Grant Health High Risk Woman Home Human Inflammation Inflammatory Knowledge Leadership Maternal Messenger RNA Maternal-fetal medicine Measures Mentors Mentorship Methodology Methods Mid-Career Clinical Scientist Award (K24)Mission Monitor Mutation National Institute of Environmental Health Sciences Neonatology Nitric Oxide Pathway North Carolina Patient Self-Report Pharmacogenomics Phase Physicians Placenta Play Postdoctoral Fellow Pregnancy Pregnant Women Premature Birth Prevention therapy Progesterone Recruitment Activity Recurrence Reproductive Health Research Research Personnel Research Project Grants Research Training Resources Risk Risk Factors Risk Reduction Role Scientist Serum Statistical Methods Surveys Survivors Testing Time Toxic Environmental Substances Toxicogenomics Training Training Programs Translational Research United States National Institutes of Health Urine Woman Work Writing career career development cohort disability drinking water early pregnancy gene environment interaction global health high risk improved indexing instructor metal metabolism mortality multidimensional data multidisciplinary neonate next generation patient oriented research premature prevent prospective psychosocial racial disparity recruit relapse prevention response skills social toxicant training opportunity

项目摘要

PROJECT SUMMARY This K24 proposal builds on over a decade of clinical and translational research – which the candidate – Dr. Tracy Manuck, MD, MSc, has focused on spontaneous preterm birth (SPTB). In this application, Dr. Manuck has recruited a team of multidisciplinary faculty experts to collaborate and support her in this endeavor, one that reflects the breadth and depth of UNC’s resources in environmental research. This work will greatly augment her current portfolio in patient-oriented research, allowing her to expand her current work and incorporate environmental contaminants into her current R01 funded study (R01-MD011609), creating a rich, multi- dimensional dataset. Candidate: Dr. Manuck is a recognized thought leader in the pharmacogenomics of SPTB. She has won numerous national accolades and has led high-impact clinical prematurity studies; here, she seeks to complement these skills by incorporating toxicogenomics into her research. Mentoring Plan/Environment: Dr. Manuck has an established track record in research training, including serving as Maternal Fetal Medicine (MFM) fellowship research director and a small group instructor for 2 graduate-level grant writing courses for fellows and junior faculty. However, competing administrative and clinical responsibilities limit her available time for mentorship. K24 award support will enable a more comprehensive mentoring portfolio within prematurity, and help to develop the critical mass of researchers investigating reproductive health effects of environmental contaminant exposure that is urgently needed in this field. With K24 support, she will have the appropriate time and resources to mentor advanced trainees (e.g., postdoctoral fellows, junior faculty) in their pursuit of independent funding. Dr. Manuck will leverage UNC’s extensive resources to accomplish this goal, including NIH-funded centers and training programs, networks and collaborations, and global health institutes. Career Goals and Objectives: Dr. Manuck will accomplish the following career development aims, including: Career Aim 1 - Expand knowledge of environmental health; Career Aim 2 - Improve mentorship skills; Career Aim 3 - Strengthen the ability to disseminate scientific results. Research Plan: Dr. Manuck will leverage her R01 study (currently recruiting) to evaluate the effects of exposure to pro-inflammatory environmental contaminants as an additional key driver of SPTB. She will integrate mentorship across the research aims: Aim 1 – Quantify exposure to environmental contaminants during pregnancy through self-report and biomonitoring of maternal urine, serum, and placentas; Aim 2 – Determine which contaminant or combination of contaminants is most strongly associated with SPTB; and Aim 3 – Test the effects of gene x environment interactions on recurrent SPTB risk. This plan offers a framework for Dr. Manuck’s training in the incorporation of environmental contaminants into prematurity studies, with potential for lifelong impact on the >450,000 babies delivered too soon in the US each year, while simultaneously providing a platform for mentoring future investigators committed to patient-oriented research.

项目摘要这项K24提案建立在十多年的临床和翻译研究的基础上 - 候选人 - 博士。医学博士的Tracy Manuck专注于赞助早产（SPTB）。在此申请中，Manuck博士有招募了一支由多学科教师专家组成的团队，以在这项工作中进行合作和支持她，这是一个反映了UNC在环境研究中资源的广度和深度。这项工作将大大增加她当前的以患者为导向研究的投资组合，使她能够扩大当前的作品并合并她当前的R01资助研究（R01-MD011609）中的环境污染物，创造了丰富的多种多样的维数据集。候选人：Manuck博士是SPTB药物基因组学的公认思想领导者。她赢得了许多国家荣誉，并领导了高影响力的临床早产研究。她在这里寻求通过将毒物组学纳入她的研究来补充这些技能。指导计划/环境：玛雅克博士在研究培训方面有着既定的记录，包括担任孕产妇医学（MFM）奖学金研究总监和一位小组教练，用于2个研究生级赠款写作课程研究员和初级教师。但是，竞争的行政和临床职责限制了她的可用时间进行训练。 K24奖励支持将使更全面的心理投资组合在早产中，并且帮助发展研究环境生殖健康影响的临界研究人员在该领域迫切需要的污染物暴露。在K24的支持下，她将有适当的时间和精神高级学员的资源（例如，博士后研究员，初级教师）追求独立资金。玛雅克博士将利用UNC的大量资源来实现这一目标，包括 NIH资助的中心和培训计划，网络和合作以及全球卫生机构。职业目标和目标：Manuck博士将完成以下职业发展目标，包括：职业目标1-扩大对环境健康的了解；职业目标2-改进技能；职业目标3- 增强传播科学结果的能力。研究计划：Manuck博士将利用她的R01研究（目前招募）评估暴露于促炎环境污染物的影响 SPTB的其他关键驱动力。她将在整个研究目标中整合Mentalship：AIM 1 - 量化暴露通过自我报告和孕产妇尿液，血清，血清的生物监测到怀孕期间的环境污染物和lopetas;目标2 - 确定污染物的污染物或组合最密切相关与SPTB； AIM 3 - 测试基因X环境相互作用对复发SPTB风险的影响。这个计划为Manuck博士在环境污染物公司培训过早的培训提供了一个框架研究，每年在美国分娩的> 450,000名婴儿的终身影响，而同样，为致力于患者研究的心理研究人员提供了一个平台。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Rates of preterm birth in multiparous women with congenital uterine anomalies.

DOI：
10.1016/j.ajogmf.2021.100392
发表时间：
2021-09
期刊：
American journal of obstetrics & gynecology MFM
影响因子：
6.3
作者：
Hynes JS;Schwartz AR;Wheeler SM;Manuck TA;Dotters-Katz SK
通讯作者：
Dotters-Katz SK

Exposure to toxic metals and per- and polyfluoroalkyl substances and the risk of preeclampsia and preterm birth in the United States: a review.

DOI：
10.1016/j.ajogmf.2021.100308
发表时间：
2021-05
期刊：
American journal of obstetrics & gynecology MFM
影响因子：
6.3
作者：
Stone J;Sutrave P;Gascoigne E;Givens MB;Fry RC;Manuck TA
通讯作者：
Manuck TA

The association between maternal and paternal race and preterm birth.

DOI：
10.1016/j.ajogmf.2021.100353
发表时间：
2021-07
期刊：
American journal of obstetrics & gynecology MFM
影响因子：
6.3
作者：
Green CA;Johnson JD;Vladutiu CJ;Manuck TA
通讯作者：
Manuck TA

Characteristics and Outcomes of Patients With Pregnancy-Related End-Stage Kidney Disease.

DOI：
10.1001/jamanetworkopen.2023.46314
发表时间：
2023-12-01
期刊：
JAMA NETWORK OPEN
影响因子：
13.8
作者：
Kucirka, Lauren M.;Angarita, Ana M.;Manuck, Tracy A.;Boggess, Kim A.;Derebail, Vimal K.;Wood, Mollie E.;Meyer, Michelle L.;Segev, Dorry L.;Reynolds, Monica L.
通讯作者：
Reynolds, Monica L.

Effects of psychological stress on adverse pregnancy outcomes and nonpharmacologic approaches for reduction: an expert review.