Vascular hemodynamics and markers of preclinical and subclinical vascular brain injury and dementia

血管血流动力学以及临床前和亚临床血管性脑损伤和痴呆的标志物

基本信息

批准号：
10541231
负责人：
Leroy Leon Cooper
金额：
$ 14.65万
依托单位：
VASSAR COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-01-01 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10541231
关键词：
Academic achievement African American African American population Aging Alzheimer&apos s Disease Amyloid beta-Protein Anisotropy Aorta Area Award Bioethics Blood Vessels Brain Brain Injuries Brain imaging Cardiovascular Physiology Cardiovascular system Cerebral Infarction Cerebrovascular Circulation Cerebrovascular Disorders Cerebrovascular Trauma Cerebrovascular system Clinical Cohort Studies Communities Complement Data Dementia Disease Progression Epidemiology Faculty Femur Framingham Heart Study Functional disorder Generations Goals Grant Impaired cognition Individual Injury Investigation Jackson Heart Study Link Magnetic Resonance Imaging Measures Mediating Memory Mentors Methods Microvascular Dysfunction Neurofibrillary Tangles Organ Participant Peptides Performance Peripheral Phase Physiologic pulse Physiology Positron-Emission Tomography Prevention Pulse Pressure Reporting Research Research Activity Research Personnel Resistance Risk Testing Training Training Activity Vascular Dementia Vascular remodeling Water White Matter Hyperintensity Work abeta accumulation arterial tonometry burden of illness cardiovascular disorder epidemiology career development career networking caucasian American cerebrovascular digital electric impedance experience health disparity hemodynamics indexing innovation member multidisciplinary neurovascular novel pre-clinical pressure racial disparity secondary analysis tau Proteins tonometry ultrasound vascular abnormality vascular factor vascular injury white matter β-amyloid burden

Academic achievement African American African American population Aging Alzheimer&apos s Disease Amyloid beta-Protein Anisotropy Aorta Area Award Bioethics Blood Vessels Brain Brain Injuries Brain imaging Cardiovascular Physiology Cardiovascular system Cerebral Infarction Cerebrovascular Circulation Cerebrovascular Disorders Cerebrovascular Trauma Cerebrovascular system Clinical Cohort Studies Communities Complement Data Dementia Disease Progression Epidemiology Faculty Femur Framingham Heart Study Functional disorder Generations Goals Grant Impaired cognition Individual Injury Investigation Jackson Heart Study Link Magnetic Resonance Imaging Measures Mediating Memory Mentors Methods Microvascular Dysfunction Neurofibrillary Tangles Organ Participant Peptides Performance Peripheral Phase Physiologic pulse Physiology Positron-Emission Tomography Prevention Pulse Pressure Reporting Research Research Activity Research Personnel Resistance Risk Testing Training Training Activity Vascular Dementia Vascular remodeling Water White Matter Hyperintensity Work abeta accumulation arterial tonometry burden of illness cardiovascular disorder epidemiology career development career networking caucasian American cerebrovascular digital electric impedance experience health disparity hemodynamics indexing innovation member multidisciplinary neurovascular novel pre-clinical pressure racial disparity secondary analysis tau Proteins tonometry ultrasound vascular abnormality vascular factor vascular injury white matter β-amyloid burden

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项目摘要

Project Summary This K01 proposal describes the career development activities and research plan that will facilitate the candidate's transition to an independent investigator in the areas of vascular hemodynamics, vascular brain injury, and dementia. The candidate has a background in cardiovascular physiology and epidemiology, including training in quantitative methods and primary and secondary analysis of vascular hemodynamics data from arterial tonometry and ultrasound. The grant will provide the applicant with additional needed training in neurovascular and brain imaging (i.e., magnetic resonance imaging and positron emission tomography), vascular and Alzheimer's disease dementia, bioethics, and grantsmanship through a combination of immersive training, coursework, mentoring, and selected readings. The candidate has assembled a team of multidisciplinary mentors and advisors who have an outstanding record of academic achievement and research expertise in the areas of vascular hemodynamics, target organ damage, vascular brain injury, and dementia. Additionally, the mentoring team members have extensive experience in mentoring junior faculty toward research independence. The proposed research will contribute to the field and complement the candidate's plan for career development training activities. The research activities will capitalize on the candidate's emerging expertise and experience in vascular hemodynamics and epidemiology with the mentors' and advisors' expertise in neurovascular function, preclinical dementia, and subclinical brain injury. The research includes multiple specific aims that will be achieved over the course of the award period. The aims include: (1) To assess relations of measures of aortic stiffness, pressure pulsatility, and microvascular function with preclinical β-amyloid and tau burden in the brain in Framingham Heart Study (FHS) Third Generation participants; (2) To assess relations of measures of aortic stiffness and pressure pulsatility with longitudinal progression of subclinical brain vascular injury in FHS Third Generation participants; and (3) To assess relations of measures of aortic stiffness and pressure pulsatility with (A) markers of cerebrovascular remodeling and (B) preclinical β-amyloid burden in the brain in a pilot subset of black/African-American participants in the Jackson Heart Study. This work seeks to elucidate nascent vascular factors that contribute to the pathophysiology of vascular brain injury and dementia, which may represent novel targets for prevention. Additionally, this work seeks to increase our understanding of health disparities of cardio- and cerebrovascular diseases.

项目摘要该K01提案描述了职业发展活动和研究计划，这将促进候选人过渡到血管血流动力学领域的独立研究者受伤和痴呆症。候选人具有心血管生理学和流行病学的背景，包括培训定量方法以及血管血液动力学数据的主要和次要分析来自动脉渗透和超声波。赠款将为申请人提供其他需要的培训神经血管和脑成像（即磁共振成像和正电子发射断层扫描），血管和阿尔茨海默氏病痴呆症，生物伦理学和养育者通过沉浸式痴呆症培训，课程，心理和选定的阅读。候选人聚集了一个团队具有出色的学术成就和顾问的多学科导师和顾问在血管血液动力学，靶器官损伤，血管脑损伤和失智。此外，心理团队成员在心理初级教师方面具有丰富的经验致力于研究独立性。拟议的研究将为该领域做出贡献，并完成候选人的职业发展计划培训活动。研究活动将利用候选人的新兴专业知识和经验与导师和顾问的神经血管专业知识有关的血管血流动力学和流行病学功能，临床前痴呆和亚临床脑损伤。该研究包括多个特定目标可以在整个奖项期间实现。目的包括：（1）评估措施的关系临床前β-淀粉样蛋白和Tau Burnen的主动脉刚度，压力脉动和微血管功能 Framingham心脏研究（FHS）第三代参与者的大脑；（2）评估措施的关系 FHS中亚临床脑血管损伤的纵向进展的主动脉刚度和压力脉动性第三代参与者；（3）评估主动脉刚度和压力的度量关系用（a）脑血管重塑的标记和（b）在A中大脑中的临床前β-淀粉样蛋白伯恩杰克逊心脏研究中的黑人/非裔美国人参与者的飞行员子集。这项工作旨在阐明有助于血管脑损伤和痴呆的病理生理的新生血管因素，这可能代表预防的新目标。此外，这项工作旨在增加我们对心脏和脑血管疾病的健康差异。