Perceptions of Multipurpose Prevention Technologies Aimed at HIV/STI/unintended pregnancy among African-American Women in the Deep South

对针对南方腹地非裔美国妇女艾滋病毒/性传播感染/意外怀孕的多用途预防技术的看法

• 批准号: 10534239
• 负责人: Kristina Ayanna Tymes-Wilbekin
• 金额: $ 4.77万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534239
• 关键词: Address; Adherence; Africa South of the Sahara; African; African American; African American population; Alabama; Anti-Retroviral Agents; Area; Attitude; Award; Behavioral; Biometry; Caucasians; Clinic; Communicable Diseases; Communication; Contraceptive Agents; Contraceptive Usage; Contraceptive methods; Dapivirine; Data; Decision Making; Deep South; Development; Devices; Doctor of Philosophy; Epidemiology; Estrogens; Familiarity; Foundations; Frequencies; Future; Goals; Grant; HIV; HIV Infections; Health Care Costs; Hygiene; Infectious Disease Epidemiology; International; Interview; Kenya; Knowledge; Learning; Learning Skill; Linear Regressions; Literature; Measures; Menstruation; Mentors; Methodology; Methods; Modeling; Outcome; Perception; Periodicity; Pharmaceutical Preparations; Physicians; Population; Pregnancy; Pregnancy Rate; Prevention; Progesterone; Publishing; Randomized, Controlled Trials; Reduce health disparities; Regimen; Reporting; Reproducibility; Reproductive Behavior; Reproductive Health; Research; Research Design; Research Proposals; Risk; Scientist; Sex Behavior; Sexual Health; Sexual Transmission; Sexually Transmitted Diseases; Surveys; Technology; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Vagina; Vaginal Douching; Vaginal Ring; Vulnerable Populations; Woman; Women' s Health; Work; Writing; behavioral study; career; career development; clinical application; design; epidemiology study; experience; health disparity; high risk; high risk population; hormonal contraception; implementation context; implementation strategy; improved; interest; journal article; pharmacologic; pre-exposure prophylaxis; prevent; preventive intervention; research and development; response; responsible research conduct; skills; social culture; sociocultural determinant; success; technology development; technology validation; tool; unintended pregnancy; uptake; vaginal microbiome; Address; Adherence; Africa South of the Sahara; African; African American; African American population; Alabama; Anti-Retroviral Agents; Area; Attitude; Award; Behavioral; Biometry; Caucasians; Clinic; Communicable Diseases; Communication; Contraceptive Agents; Contraceptive Usage; Contraceptive methods; Dapivirine; Data; Decision Making; Deep South; Development; Devices; Doctor of Philosophy; Epidemiology; Estrogens; Familiarity; Foundations; Frequencies; Future; Goals; Grant; HIV; HIV Infections; Health Care Costs; Hygiene; Infectious Disease Epidemiology; International; Interview; Kenya; Knowledge; Learning; Learning Skill; Linear Regressions; Literature; Measures; Menstruation; Mentors; Methodology; Methods; Modeling; Outcome; Perception; Periodicity; Pharmaceutical Preparations; Physicians; Population; Pregnancy; Pregnancy Rate; Prevention; Progesterone; Publishing; Randomized, Controlled Trials; Reduce health disparities; Regimen; Reporting; Reproducibility; Reproductive Behavior; Reproductive Health; Research; Research Design; Research Proposals; Risk; Scientist; Sex Behavior; Sexual Health; Sexual Transmission; Sexually Transmitted Diseases; Surveys; Technology; Testing; Training; Translating; Translational Research; United States National Institutes of Health; Vagina; Vaginal Douching; Vaginal Ring; Vulnerable Populations; Woman; Women' s Health; Work; Writing; behavioral study; career; career development; clinical application; design; epidemiology study; experience; health disparity; high risk; high risk population; hormonal contraception; implementation context; implementation strategy; improved; interest; journal article; pharmacologic; pre-exposure prophylaxis; prevent; preventive intervention; research and development; response; responsible research conduct; skills; social culture; sociocultural determinant; success; technology development; technology validation; tool; unintended pregnancy; uptake; vaginal microbiome

PROJECT SUMMARY The purpose of this NIH F31- Diversity application is to obtain support for the PI, Kristina Tymes-Wilbekin, for mentored research and career development activities within her MD/PhD training that will enhance her potential to become a successful physician scientist. The project goal is to develop skills in infectious disease epidemiology and reproductive health that will allow the PI to study behavioral and socio-cultural factors that influence women’s experiences and decisions related to sexual health outcomes using mixed method study applications. The primary objective of the research proposal is to investigate potential relationships between vaginal hygiene, sexual behaviors and uptake of ring-based multipurpose prevention technologies among women at increased risk of unintended pregnancy and acquisition/transmission of sexually transmitted infections or HIV infection. Currently new vaginal rings are being developed and tested as multipurpose prevention technologies that act as a hormonal contraceptive and can prevent/treat sexually transmitted infections or HIV infection. This project is specifically focused on understanding these factors in the context of intravaginal ring delivery, due to a demonstration that a continuous contraceptive vaginal ring (CVR) regimen has potential noncontraceptive and pharmacological benefits that can increase women’s adherence. This project seeks to quantitatively characterize perception of menstrual suppression among Kenyan women pre- and post-CVR use (Aim 1), and then utilize the findings for development and application of a tool to assess similar perceptions in African-American women in the Southeastern U.S. (Aims 2A and 2B). The long-term objective of our research is to better understand women’s experience with CVRs in order to inform multipurpose prevention technology development and improve sexual health options among high-risk populations. The proposed training plan for the PI is sponsored by her project co-mentors, Dr. Jeanne Marrazzo and Dr. Sadeep Shrestha. Included within the training plan are objectives to help develop the PI in three major areas: (1) rigorous research in the STI/HIV, contraception, and multipurpose prevention technology fields, including familiarity with the existing literature, critically evaluating published studies, principles of scientific integrity and responsible conduct of research, and methods or rigor and reproducibility; and (2) infectious disease epidemiology, including methodology, study design, and biostatistical analysis; and (3) career and professional development, inclusive of communication through presentations, journal article review, learning skills in grant writing, and translation of research findings for clinical applications. The overall goal of this training plan is to give the PI a foundation for a successful progression as a physician scientist and furthering the PI’s ultimate career goal of working with a collaborative team that bridges the gap between epidemiological research and improvement in women’s reproductive and sexual health outcomes.

项目摘要 NIH F31的目的 - 多样性应用是为了获得PI的支持Kristina Tymes-Wilbekin，用于 在她的医学博士/博士培训中迈出了研究和职业发展活动，这将提高她的潜力 成为一名成功的物理科学家。项目目标是发展传染病的技能 流行病学和生殖健康将使PI能够研究行为和社会文化因素 使用混合方法研究影响妇女与性健康结果有关的经验和决定 申请。研究建议的主要目的是研究 阴道卫生，性行为和对环的多功能预防技术的吸收 妇女有意外怀孕和收购/传播性传播感染的风险增加 或HIV感染。目前，正在开发新的阴道环作为预防多功能 充当激素避孕药并可以预防/治疗性传播感染或艾滋病毒的技术 感染。该项目专门针对在阴道内环的背景下理解这些因素 交付，由于证明了连续的避孕阴道环（CVR）具有潜力 可以增加妇女依从性的非关注和药理益处。这个项目试图 肯尼亚妇女在CVR前后，定量表征对月经抑制的感知 （AIM 1），然后利用发现和应用工具来评估类似的看法 美国东南部的非裔美国妇女（目标2A和2B）。我们研究的长期目标 是为了更好地了解女性在CVR中的经验，以便为多用途预防技术提供信息 在高风险人群中发展和改善性健康选择。 PI的拟议培训计划由她的项目联合会员Jeanne Marrazzo博士和 Sadeep Shrestha博士。培训计划中包括的目标是帮助在三个主要领域开发PI： （1）STI/HIV，避孕和多用途预防技术领域的严格研究，包括 熟悉现有文献，批判性评估已发表的研究，科学完整性原理和 负责任的研究，方法或严格性和可重复性； （2）传染病 流行病学，包括方法，研究设计和生物统计分析； （3）职业和专业 开发，包括通过演示文稿的沟通，期刊文章评论，赠款中的学习技能 临床应用研究结果的写作和翻译。该培训计划的总体目标是 为PI取得成功发展的基础，并促进PI的最终 与一个合作团队合作的职业目标，该团队弥合了流行病学研究与 妇女的生殖和性健康成果的改善。