A-Z Clinical Trials Unit

A-Z 临床试验单位

• 批准号: 10528462
• 负责人: Paul A. Goepfert
• 金额: $ 186.27万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10528462
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Address; Africa South of the Sahara; Alabama; Caring; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Collaborations; Communication; Creativeness; Data; Dedications; Development; Eligibility Determination; Enrollment; Ensure; Epidemic; Faculty; Female; Foundations; Funding; Geographic Locations; HIV; HIV Infections; HIV Vaccine Trials Network; HIV/AIDS; Hepatitis B; Incidence; Infectious Diseases Research; Institution; International; Laboratory Research; Leadership; Longevity; Medicine; Mentors; Minority; Names; National Institute of Allergy and Infectious Disease; Network-based; Participant; Performance; Persons; Pharmacy facility; Population; Populations at Risk; Prevention trial; Problem Solving; Procedures; Protocols documentation; Publications; Readiness; Research; Research Infrastructure; Research Methodology; Research Personnel; Risk; Sampling; Science; Scientific Advances and Accomplishments; Site; Talents; Tuberculosis; United States National Institutes of Health; Universities; Zambia; clinical research site; community engagement; comorbidity; data management; disparity elimination; expectation; experience; flexibility; improved; laboratory facility; member; multidisciplinary; participant retention; scale up; support network; vaccine trial

The Alabama to Zambia Clinical Trials Unit (A-to-Z CTU) represents a collaboration between the University of Alabama at Birmingham (UAB) and the Centre for Infectious Diseases Research in Zambia (CIDRZ). UAB has been continuously funded to perform NIH-funded HIV network clinical trials since 1990 and in 2015 added the CIDRZ CRS at the request of DAIDS. Over the past 6 years, our team has successfully enrolled over 1000 participants, including 45% female and 59% minority participants, into 48 network trials and contributed to over 175 publications of the networks. We have met or exceeded the expectations regarding enrollment, retention, data management, pharmacy management, and laboratory facilities and metrics. The past performance of the A-to-Z CTU exemplifies the preparedness of our team to contribute to the science of the NIH-funded HIV clinical trials networks for the next seven years. In this application, we highlight the A-to-Z CTU commitment to HIV research with the following specific aims: Aim 1. Enroll and retain participants efficiently into HIV clinical trials at our two clinical research sites capable of yielding the highest quality data to meet the needs of the HVTN, the HPTN and the ACTG scientific networks and their respective scientific research agendas. Aim 2. Maintain a cohesive, integrated group of investigators and staff where communication, community engagement, interaction, problem solving, flexible staffing, quality data and sample management, and regulatory assurance currently exist as evident via our track record of high-quality performance. Aim 3. Contribute to the respective scientific agendas by remaining engaged with the network leadership to respond quickly to emerging scientific priorities, including the ability to rapidly scale-up a protocol- specific site for targeted, high-priority studies for any DAIDS-funded research network. Aim 4. Mentor a talented group of young investigators who will lay the foundation for continued excellence in this ever-changing field of HIV research domestically and internationally. We will leverage our long-standing experience in clinical trials to contribute to HIV research through the NIH- funded HIV clinical trial networks.

阿拉巴马州到赞比亚临床试验部（A-TO-Z CTU）代表大学之间的合作 伯明翰（UAB）的阿拉巴马州和赞比亚的传染病研究中心（Cidrz）。 UAB有 自1990年以来一直被持续资助用于执行NIH资助的HIV网络临床试验，并在2015年增加了 Cidrz Crs应daids的要求。在过去的6年中，我们的团队已成功招募了1000多个 参与者，包括45％的女性和59％的少数族裔参与者，参加了48个网络试验，并有助于过度 175网络出版物。我们已经达到或超出了有关入学，保留， 数据管理，药房管理以及实验室设施和指标。过去的表现 A到Z CTU例证了我们团队为NIH资助的HIV临床科学做出贡献的准备 试验网络将在接下来的七年中。在此应用程序中，我们重点介绍了A-to-Z CTU对艾滋病毒的承诺 具有以下具体目的的研究： 目标1。在我们的两个能够的临床研究地点，有效地注册并保留参与者参加HIV临床试验 产生最高质量的数据以满足HVTN，HPTN和ACTG科学的需求 网络及其各自的科学研究议程。 目标2。保持一个凝聚力，综合的调查人员和员工群体，沟通，社区 参与，互动，解决问题，灵活人员配备，质量数据和样本管理以及 当前，通过我们的高质量性能记录，监管保证目前是显而易见的。 目标3。通过与网络领导互动来为各自的科学议程做出贡献 迅速对新兴的科学优先级做出响应，包括快速扩大协议的能力 - 针对任何由DAIDS资助的研究网络有针对性的高优先级研究的特定地点。 目标4。指导一群才华横溢的年轻调查员，他们将奠定持续卓越的基础 艾滋病毒在国内和国际上进行的艾滋病毒研究不断变化的领域。 我们将利用我们在临床试验中的长期经验，通过NIH- 资助的HIV临床试验网络。