UAB Cardiovascular Disease Predoctoral Training Program in Biostatistics and Epidemiology

UAB心血管疾病生物统计学和流行病学博士前培训项目

• 批准号: 10531226
• 负责人: Marguerite R Irvin
• 金额: $ 18.9万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10531226
• 关键词: Biometry; Cardiovascular Diseases; Epidemiology; Training Programs; pre-doctoral

The increasing availability of “big data” has transformed the training required to advance our understanding of the pathophysiology of cardiovascular disease (CVD), the identification of patient-level and public health approaches to prevent its occurrence and aspects of quality of care for patients with CVD and its risk factors. The goal of the proposed pre-doctoral National Heart, Lung, and Blood Institute T32 CVD training grant is to engage and empower biostatistics and epidemiology students with a strong foundation in both disciplines so they will be positioned to lead the design, conduct and analysis of the big data that are being collected in the 21st century. Located in the Southeastern US, an area with the highest heart disease death rates, the University of Alabama at Birmingham (UAB) has been at the forefront of CVD biostatistics and epidemiology research for over 25 years. The Departments of Biostatistics and Epidemiology are internationally recognized for leading randomized trial coordinating centers, serving as the coordinating center and field sites for epidemiology studies, conducting analyses of health insurance claims and electronic medical record data, and developing new methods for statistical genetics/genomics. For this T32 program, we are requesting funding for a total of 12 pre-doctoral trainees over the course of 5 years including 2 new trainees in each of years 1 through 3 and 3 new trainees in each of years 4 and 5. Trainees enrolled in the T32 program will receive a strong foundation in the pathophysiology and epidemiology of CVD, skills to design and conduct observational research, training on rigor and reproducibility in CVD research, familiarity with how real-world data are collected and analyzed, experience conducting big data analytics including omics data, grant writing experience, and networking opportunities within UAB and the larger scientific community of CVD researchers. Pre-doctoral trainees will complete activities that provide added value to their doctoral programs in biostatistics and epidemiology including didactic cross-training courses, a grant writing class and workshop, research immersions in three areas of big data, professional development workshops, and CVD seminars and a journal club. We have designed three workshops for this T32 grant including an 8-week summer training program on CVD, a high performance computing boot camp and a workshop on team science and communication. The training program’s capstone experience is a mentored research project resulting in a peer-reviewed manuscript. The program will be led by Drs. Hemant Tiwari and Paul Muntner, full professors in Biostatistics and Epidemiology, respectively, with strong mentoring records and program development experience. We have received the commitment from 14 primary mentors and 11 secondary mentors from the Departments of Biostatistics and Epidemiology. An additional 21 faculty members from across UAB have committed to serve as content mentors. The proposed pre-doctoral T32 Training Program will produce a cadre of biostatisticians and epidemiologists prepared to lead CVD research studies that address the priorities of NHLBI.

“大数据”的可用性不断增加，改变了加深我们对大数据的理解所需的培训 心血管疾病（CVD）的病理生理学、患者水平和公共卫生的识别 预防其发生的方法以及 CVD 患者的护理质量及其危险因素。 拟议的博士前国家心肺血液研究所 T32 CVD 培训补助金的目标是 吸引生物统计学和流行病学学生在这两个学科上拥有坚实的基础，并赋予他们权力，以便 他们将负责领导正在收集的大数据的设计、实施和分析。 21世纪，美国东南部是心脏病死亡率最高的地区。 阿拉巴马大学伯明翰分校 (UAB) 一直处于 CVD 生物统计学和流行病学的前沿 生物统计学和流行病学系的研究已超过 25 年。 领先的随机试验协调中心，作为协调中心和现场站点 流行病学研究，对健康保险索赔和电子病历数据进行分析，以及 开发统计遗传学/基因组学的新方法 对于这个 T32 项目，我们正在申请资金。 5 年期间总共 12 名博士前培训生，其中每年 1 名新培训生 第 4 年和第 5 年每年分别有 3 名和 3 名新学员。参加 T32 计划的学员将获得 CVD 病理生理学和流行病学基础，设计和进行观察的技能 研究、CVD 研究的严谨性和可重复性培训、熟悉真实世界数据的情况 收集和分析、进行大数据分析（包括组学数据）、资助写作的经验 经验，以及 UAB 和更大的 CVD 研究人员科学界的交流机会。 博士前学员将完成为其生物统计学博士课程提供附加值的活动 和流行病学，包括教学交叉培训课程、资助写作课程和研讨会、研究 沉浸在大数据、专业发展研讨会、CVD 研讨会和期刊三个领域 我们为 T32 拨款设计了三个研讨会，其中包括为期 8 周的夏季培训计划。 CVD、高性能计算训练营和团队科学与沟通研讨会。 培训计划的顶点经验是一个指导性的研究项目，其结果是经过同行评审的 该项目将由生物统计学正教授 Hemant Tiwari 和 Paul Muntner 博士领导。 和流行病学，分别具有丰富的指导记录和项目开发经验。 已收到来自各部门的 14 名初级导师和 11 名二级导师的承诺 来自 UAB 的另外 21 名教员已承诺为生物统计学和流行病学服务。 拟议的博士前 T32 培训计划将培养一支生物统计学家骨干队伍。 流行病学家准备领导 CVD 研究，解决 NHLBI 的优先事项。