Integration of acoustic and electric hearing within or across ears

耳内或耳外声学和电学听力的集成

• 批准号: 10527345
• 负责人: Qian-Jie Fu
• 金额: $ 33.15万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527345
• 关键词: Acoustic Stimulation; Acoustics; Adverse effects; Affect; Apical; Auditory; Binaural; Clinic; Clinical; Cochlea; Cochlear Implants; Contralateral; Data; Deterioration; Devices; Ear; Electric Stimulation; Electrodes; Emotions; Frequencies; Goals; Hearing; Hearing Aids; Ipsilateral; Measures; Modality; Noise; Patients; Pattern; Performance; Research; Residual state; Resolution; Speech; base; experience; experimental study; hearing impairment; improved; insight; interest; neural; normal hearing; radiological imaging; signal processing; simulation; sound; Acoustic Stimulation; Acoustics; Adverse effects; Affect; Apical; Auditory; Binaural; Clinic; Clinical; Cochlea; Cochlear Implants; Contralateral; Data; Deterioration; Devices; Ear; Electric Stimulation; Electrodes; Emotions; Frequencies; Goals; Hearing; Hearing Aids; Ipsilateral; Measures; Modality; Noise; Patients; Pattern; Performance; Research; Residual state; Resolution; Speech; base; experience; experimental study; hearing impairment; improved; insight; interest; neural; normal hearing; radiological imaging; signal processing; simulation; sound

SUMMARY: Increasing numbers of cochlear implant (CI) patients are able to combine residual acoustic hearing (AH) with electric hearing (EH) in the same ear (electric-acoustic stimulation, or EAS), across ears (bimodal), or both (biEAS). The benefits of acoustic-electric hearing (AEH) are variable; some CI users even experience interference between acoustic and electric stimulation patterns. In the clinic, there is little effort to optimize CI and/or hearing aid signal processing with regard to combined acoustic and electric hearing, and it is unclear whether acoustic and electric patterns are combined differently within or across ears. EAS and biEAS patients may experience energetic interference between the current spread from EH and the spread of excitation (SOE) from AH. Bimodal, EAS, and biEAS patients may also experience informational interference because the same acoustic input may be delivered to different cochlear places (tonotopic mismatch) within and/or across ears. To mitigate these adverse effects, the optimal fitting for CI and/or hearing aid devices might be quite different for AEH than for EH and/or AH. The long-term goals of this proposal are to understand the mechanisms that underlie integration of acoustic and electric hearing, which can be used to improve AEH benefits for CI users. We hypothesize that acoustic and electric stimulation patterns are integrated differently within and across ears. Specifically, we hypothesize that integration for EAS listeners is limited by both energetic and informational interference; reducing the current spread/SOE between AH and EH and reducing tonotopic mismatch may improve integration. We also hypothesize that integration for bimodal listeners is limited by informational interference, due to tonotopic mismatch and sound quality differences across ears; improving the sound quality of EH (e.g., focused stimulation) while reducing the tonotopic mismatch between AH and EH may improve integration. Acoustic-electric integration will be evaluated in pairs of parallel experiments with normal-hearing (NH) subjects listening to simulations of AEH and in real EAS, bimodal, and biEAS CI listeners. Speech measures (vowel and sentence recognition in quiet and in noise, vocal emotion recognition) and frequency resolution will be collected with AH, EH, and AEH, and evaluated in terms of overall AEH performance, AEH benefit (performance difference between AEH and AH or EH), and integration efficiency (the ratio between observed and predicted AEH performance). Aim 1 will primarily explore aspects of electric hearing that affect acoustic-electric integration while Aim 2 will focus on aspects of acoustic hearing that affect acoustic-electric integration. The proposed research is of great theoretical interest, as it will provide greater insight into acoustic-electric integration for AEH. The proposed research is also of great clinical value, as the results may provide better guidance for optimizing CI signal processing for AEH.

摘要：越来越多的人工耳蜗（CI）患者能够结合残留声。 在耳朵的同一耳朵（电声刺激或EAS）的电气听力（EH）的听力（AH） （双峰），或两者（BIEAS）。声音听力（AEH）的好处是可变的；甚至一些CI用户 经历声学和电刺激模式之间的干扰。在诊所里，努力很少 为了优化CI和/或助听器信号处理，以进行声音和电气听力的合并 目前尚不清楚声学和电力模式在耳朵内还是在耳朵内或跨耳朵之间的组合。 EAS BIEAS患者可能会在电流从EH和 激发（SOE）从AH传播。双峰，EA和BIEAS患者也可能会遇到信息 干涉，因为相同的声学输入可以传递到不同的人工耳蜗（吨位 不匹配）和/或跨耳朵。为了减轻这些不利影响，CI和/或 AEH的助听器设备与EH和/或AH可能完全不同。 该提案的长期目标是了解基于整合的机制 声学和电气听力，可用于改善CI使用者的AEH福利。我们假设这一点 声学和电刺激模式在耳朵内部和跨耳朵内的集成方式不同。具体来说，我们 假设EAS听众的整合受到充满活力和信息干扰的限制。 减少AH和EH之间的当前扩散/SOE并减少Tonotopic不匹配可能会有所改善 一体化。我们还假设，双峰听众的整合受到信息干扰的限制， 由于调整不匹配和声音质量差异，耳朵的声音差异；提高EH的音质 （例如，集中刺激）同时减少AH和EH之间的调整不匹配可能会有所改善 一体化。声学整合将通过正常听力的平行实验对评估 （NH）主张听取对AEH的模拟以及实际EAS，BIMODAL和BIEAS CI听众的模拟。演讲 措施（在噪音和噪音，声音识别中识别元音和句子识别）和频率 分辨率将与AH，EH和AEH收集，并根据AEH的整体绩效进行评估 益处（AEH和AH或EH之间的性能差异）和集成效率（之间的比率 观察并预测了AEH性能）。 AIM 1将主要探索影响的电气听力的各个方面 AIM 2的声学融合将集中在影响声学的声学听力方面 一体化。拟议的研究具有很大的理论利益，因为它将为 AEH的声学整合。拟议的研究也具有巨大的临床价值，因为结果 可以提供更好的指导来优化AEH的CI信号处理。