Integration of acoustic and electric hearing within or across ears

耳内或耳外声学和电学听力的集成

基本信息

批准号：
10527345
负责人：
Qian-Jie Fu
金额：
$ 33.15万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-01 至 2024-11-30
项目状态：
已结题

项目摘要

SUMMARY: Increasing numbers of cochlear implant (CI) patients are able to combine residual acoustic hearing (AH) with electric hearing (EH) in the same ear (electric-acoustic stimulation, or EAS), across ears (bimodal), or both (biEAS). The benefits of acoustic-electric hearing (AEH) are variable; some CI users even experience interference between acoustic and electric stimulation patterns. In the clinic, there is little effort to optimize CI and/or hearing aid signal processing with regard to combined acoustic and electric hearing, and it is unclear whether acoustic and electric patterns are combined differently within or across ears. EAS and biEAS patients may experience energetic interference between the current spread from EH and the spread of excitation (SOE) from AH. Bimodal, EAS, and biEAS patients may also experience informational interference because the same acoustic input may be delivered to different cochlear places (tonotopic mismatch) within and/or across ears. To mitigate these adverse effects, the optimal fitting for CI and/or hearing aid devices might be quite different for AEH than for EH and/or AH. The long-term goals of this proposal are to understand the mechanisms that underlie integration of acoustic and electric hearing, which can be used to improve AEH benefits for CI users. We hypothesize that acoustic and electric stimulation patterns are integrated differently within and across ears. Specifically, we hypothesize that integration for EAS listeners is limited by both energetic and informational interference; reducing the current spread/SOE between AH and EH and reducing tonotopic mismatch may improve integration. We also hypothesize that integration for bimodal listeners is limited by informational interference, due to tonotopic mismatch and sound quality differences across ears; improving the sound quality of EH (e.g., focused stimulation) while reducing the tonotopic mismatch between AH and EH may improve integration. Acoustic-electric integration will be evaluated in pairs of parallel experiments with normal-hearing (NH) subjects listening to simulations of AEH and in real EAS, bimodal, and biEAS CI listeners. Speech measures (vowel and sentence recognition in quiet and in noise, vocal emotion recognition) and frequency resolution will be collected with AH, EH, and AEH, and evaluated in terms of overall AEH performance, AEH benefit (performance difference between AEH and AH or EH), and integration efficiency (the ratio between observed and predicted AEH performance). Aim 1 will primarily explore aspects of electric hearing that affect acoustic-electric integration while Aim 2 will focus on aspects of acoustic hearing that affect acoustic-electric integration. The proposed research is of great theoretical interest, as it will provide greater insight into acoustic-electric integration for AEH. The proposed research is also of great clinical value, as the results may provide better guidance for optimizing CI signal processing for AEH.

摘要：越来越多的人工耳蜗 (CI) 患者能够将残余声学结合起来同耳听力 (AH) 和电听力 (EH)（电声刺激或 EAS）、跨耳（双峰），或两者（biEAS）。声电听力 (AEH) 的好处是多种多样的；一些 CI 用户甚至体验声刺激模式和电刺激模式之间的干扰。在诊所，几乎不需要付出什么努力优化 CI 和/或助听器信号处理，以结合声学和电学听力，目前尚不清楚声学和电学模式在耳朵内或耳朵之间的组合是否不同。电子防盗系统 biEAS 患者可能会经历来自 EH 的电流传播与来自 AH 的激励扩散 (SOE)。双峰、EAS 和 biEAS 患者也可能会体验到信息干扰，因为相同的声输入可能会传递到不同的耳蜗位置（音调不匹配）在耳朵内和/或跨过耳朵。为了减轻这些不利影响，CI 和/或的最佳拟合用于 AEH 的助听器可能与用于 EH 和/或 AH 的助听器有很大不同。该提案的长期目标是了解整合的机制声学和电学听力，可用于改善 CI 用户的 AEH 益处。我们假设声学和电刺激模式在耳朵内和耳朵之间的集成方式不同。具体来说，我们假设 EAS 听众的整合受到能量和信息干扰的限制；减少 AH 和 EH 之间的当前价差/SOE 并减少音调不匹配可能会改善一体化。我们还假设双模听众的整合受到信息干扰的限制，由于音调不匹配和耳朵之间的音质差异；提高EH的音质（例如，集中刺激）同时减少 AH 和 EH 之间的音调不匹配可能会改善一体化。声电一体化将在正常听力的一对平行实验中进行评估 (NH) 受试者聆听 AEH 模拟以及真实 EAS、双峰和 biEAS CI 听众。演讲测量（安静和噪音中的元音和句子识别、声音情感识别）和频率分辨率将通过 AH、EH 和 AEH 进行收集，并根据整体 AEH 性能、AEH 进行评估效益（AEH 与 AH 或 EH 之间的性能差异）和集成效率（AEH 与 AH 或 EH 之间的比率）观察并预测 AEH 表现）。目标 1 将主要探讨影响电听力的各个方面声电一体化，而 Aim 2 将重点关注影响声电的声学听力方面一体化。拟议的研究具有很大的理论意义，因为它将提供更深入的见解 AEH 的声电一体化。所提出的研究也具有很大的临床价值，因为结果可以为优化 AEH 的 CI 信号处理提供更好的指导。