A proteomics research specialist in developing targeted mass spectrometry methods for quantifying proteins important in cancer

蛋白质组学研究专家，开发靶向质谱方法来量化癌症中重要的蛋白质

基本信息

批准号：
10517132
负责人：
Jeff Whiteaker
金额：
$ 31.08万
依托单位：
FRED HUTCHINSON CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-19 至 2027-08-31
项目状态：
未结题

项目摘要

Project Summary / Abstract The Paulovich laboratory is a translational oncology lab specializing in proteomics with a goal to improve personalized medicine through elucidating cancer mechanisms, diagnosing disease, and predicting response to therapy. A major roadblock to achieving these goals is the lack of standardized assays for the quantification of proteins, which form the basis of diagnostics and are targets for treatments. To address this need, our research program is focusing on three arms: i) the development of novel applications of targeted mass spectrometry for precise, multiplexed, and reproducible quantitation of proteins, ii) the standardization of protein measurements through establishing community resources for the dissemination of the technology to the biomedical research community, and iii) the measurement of proteins and post-translational modifications in biological samples for fundamental biological insight to cancer mechanisms and translating findings to clinical use. Dr. Jeffrey Whiteaker, a research specialist in the Paulovich laboratory, is vital to achieving success in this interdisciplinary effort due to: his role as leader of all proteomics activities in the laboratory, his vast experience in the field of analytical chemistry and mass spectrometry, and the guidance he provides within the laboratory. He will continue to guide efforts aimed at expanding the technology to cancer-relevant pathways and disseminating the technology to the biomedical research community, enabling the translation of new discoveries to clinical care and the benefit of patients.

项目摘要 /摘要 Paulovich实验室是一个专门研究蛋白质组学的转化肿瘤学实验室，其目标是改进通过阐明癌症机制，诊断疾病和预测反应来个性化医学接受治疗。实现这些目标的主要障碍是缺乏量化标准化测定法蛋白质的蛋白质，构成诊断的基础，是治疗靶标。为了满足这一需求，我们研究计划的重点是三个臂：i）针对目标的新应用的发展用于精确，多路复用和可再现定量蛋白质的光谱法，ii）蛋白质测量通过建立社区资源来传播技术生物医学研究界和iii）测量蛋白质和翻译后修饰在生物样品中，用于癌症机制的基本生物学见解，并将发现转化为临床用途。 Paulovich实验室的研究专家Jeffrey Whiteaker博士对于实现至关重要由于：他作为实验室所有蛋白质组学活动的领导者的角色，他的跨学科努力的成功在分析化学和质谱领域的丰富经验以及他提供的指导在实验室内。他将继续指导旨在将技术扩展到与癌症相关的努力途径并将技术传播给生物医学研究界，使得能够翻译临床护理的新发现和患者的好处。