Enhancing transport and delivery of ferrihydrite nanoparticles via polymer encapsulation in PFAS-contaminated sediments to simulate PFAS defluorination by Acidimicrobium sp. Strain A6

通过聚合物封装在 PFAS 污染的沉积物中增强水铁矿纳米粒子的运输和递送，以模拟 Acidimicrobium sp 的 PFAS 脱氟。

• 批准号: 10515660
• 负责人: Peter R. Jaffe
• 金额: $ 30.56万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-16 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10515660
• 关键词: Affect; Ammonium; Animals; Bacteria; Biological Availability; Bioremediations; Chemistry; Defect; Development; Drug Metabolic Detoxication; Electron Transport; Encapsulated; Environment; Environmental Engineering technology; Frequencies; Gene Expression; Genes; Goals; Growth; Health; Immunologics; In Situ; Incubated; Injections; Iron; Knowledge; Laboratories; Laboratory Animals; Learning; Methods; Microbiology; Monitor; Organism; Outcome; Oxidants; Oxidation-Reduction; Periodicals; Phase; Poly-fluoroalkyl substances; Polymers; Porosity; Process; Property; Reporting; Research; Resources; Scheme; Silicon Dioxide; Site; Soil; Solid; Source; Suspensions; Techniques; Technology; Testing; Time; Uranium; Vial device; Water; acrylic acid; aqueous; consumer product; contaminated sediment; design; drinking water; electron donor; experimental study; exposed human population; ferrihydrite; ground water; hydrology; innovation; insight; liver injury; materials science; mineralization; nano; nanoparticle; novel; operation; oxidation; particle; perfluorooctane sulfonate; perfluorooctanoic acid; pollutant; remediation; renal damage; reproductive; tumor; water quality

Project Summary/Abstract Per- and polyfluoroalkyl substances (PFAS) are ubiquitous in the environment and highly stable. They are present in many consumer products and over 4000 different PFAS have been synthesized. Among the most common and of most concern are perfluorooctanoic acid (PFOA) and perfluoro octane sulfonate (PFOS), for which the EPA reports that these compounds can cause reproductive and developmental defects, liver and kidney damage, and immunological effects in laboratory animals, and that they may cause tumors in animal studies. Due to the strong C-F bond, no defluorination followed by mineralization of perfluorinated compounds has been reported so far, except PFAS defluorination by the recently discovered and isolated Feammox bacterium Acidimicrobium sp. Strain A6 (A6). A6 oxidizes ammonium (NH4+) while reducing ferric iron (Fe(III)), and it can during this process also transfer electrons to PFAS and defluorinate them. Bioremediation/biostimulation usually requires achieving proper biogeochemical conditions via the supply of appropriate electron donors/acceptors, redox potential manipulation, and bioaugmentation if the required organism is not present. A6 is common in iron-rich acidic soils, indicating that biostimulation could be an appropriate technology in many cases to use this organism for PFAS bioremediation schemes. Under electron donor/acceptor limiting conditions, it is easy to supply NH4+ to an aquifer, while it is challenging to supply and spatially distribute solid-phase Fe(III), requiring novel methods to enhance the transport of Fe(III) phases. We hypothesize that polymer encapsulated nano-ferrihydrite can be delivered throughout a porous medium to stimulate the activity of A6 and its defluorination of PFAS. Hence, the Aims of this project include: (1) develop polymer-encapsulated nano-ferrihydrite particles that have increased transport properties in a porous medium; (2) ascertain that the polymer-encapsulated nano-ferrihydrite is bioavailable and enhances PFAS defluorination by A6; and (3) determine via soil column experiments how to supply the polymer-encapsulated nano-ferrihydrite to enhance the A6 activity and its defluorination of PFAS. The outcome of this project will result in the first approach to design and operate a bioremediation scheme to defluorinate PFAS, which are of increasing health concern and for which drinking water is the main exposure for humans. This will be achieved by combining techniques and experimental methods from material science, microbiology, and hydrology/environmental engineering. The project will provide new knowledge on how to supply a Fe(III) source, which also has other remediation applications, provide new insights on how to stimulate A6 for the bioremediation of PFAS and other pollutants, and show how to integrate these findings for an effective PFAS bioremediation scheme that is able to operate for extended time periods in order to achieve desired final concentration/water quality goals.

项目摘要/摘要 每种和多氟烷基物质（PFA）在环境中无处不在，并且高度稳定。他们 存在于许多消费产品中，并且已经合成了4000多种不同的PFA。之中 最常见和最关注的是全氟辛酸（PFOA）和Pertluoro 辛烷值磺酸盐 （PFO），EPA报告这些化合物会引起生殖和发育 缺陷，肝脏和肾脏损害以及实验动物的免疫学影响，并且可能 在动物研究中引起肿瘤。由于C-F键牢固，没有脱氟化，然后进行矿化 到目前为止，据报道，全氟化化合物已经报道了 发现并分离的猫莫克斯细菌酸性细菌sp。应变A6（A6）。 A6在还原铁（Fe（III））的同时氧化铵（NH4+），并且在此过程中也可以 将电子转移到PFAS并放流它们。生物修复/生物刺激通常需要 通过供应适当的电子供体/受体来实现适当的生物地球化学条件， 如果不存在所需的生物，氧化还原的潜在操作和生物提升。 A6是 在富含铁的酸性土壤中常见，表明生物刺激可能是适当的技术 许多使用这种生物用于PFA的生物修复方案的情况。在电子供体/受体下 限制条件，很容易向含水层提供NH4+，而在供应和空间上都具有挑战性 分布固相Fe（III），需要新的方法来增强Fe（III）阶段的运输。我们 假设聚合物封装的纳米粉脂石可以在多孔的培养基中递送 刺激A6的活性及其PFA的脱氟。因此，该项目的目的包括：（1） 开发聚合物封装的纳米 - 富集液颗粒，这些颗粒在A中提高了运输特性 多孔培养基； （2）确定聚合物封装的纳米粉状液体是生物利用的，并且 通过A6增强PFAS脱氟化； （3）通过土壤柱实验确定如何提供 聚合物封装的纳米粉氢钛矿可增强A6活性及其PFA的脱氟。 该项目的结果将导致首先设计和操作生物修复的方法 脱氟PFA的计划，这些PFA越来越关注健康，饮用水是 人类的主要接触。这将通过结合技术和实验方法来实现 来自材料科学，微生物学和水文学/环境工程。该项目将提供 有关如何提供FE（III）来源的新知识，该资源也具有其他补救申请， 有关如何刺激A6的新见解，以进行PFA和其他污染物的生物修复，并展示 将这些发现集成为有效的PFA生物修复方案，该计划能够为 延长时间段，以实现所需的最终集中/水质目标。

项目成果

Enhanced Feammox activity and perfluorooctanoic acid (PFOA) degradation by Acidimicrobium sp. Strain A6 using PAA-coated ferrihydrite as an electron acceptor.

• DOI: 10.1016/j.jhazmat.2023.132039
• 发表时间: 2023-07
• 期刊: Journal of hazardous materials
• 影响因子: 13.6
• 作者: Jinhee Park;Shan Huang;B. Koel;P. Jaffé