Do long working hours increase the risk of cardiovascular disease mortality? Evidence from the U.S. National Health Interview Survey 1997-2015

长时间工作会增加心血管疾病死亡风险吗？

• 批准号: 10509317
• 负责人: Jian Li
• 金额: $ 19.56万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10509317
• 关键词: Do; long; working; hours; increase; Do; long; working; hours; increase

ABSTRACT Cardiovascular disease (CVD, including heart disease and stroke) is the leading cause of death worldwide and in the United States (U.S.), accounting for 2.8 million deaths in 2018 alone and with a prevalence nearing 50%.1,2 Related to this are long working hours, which remain quite high in the U.S. when compared to other countries.3,4 Recently, a series of systematic reviews and meta-analyses have identified a robust and dose-dependent relationship between long working hours and CVD.5–9 These reviews reported that working more than 55 hours a week was associated with a higher risk of CVD mortality in the European workforce. However, this association has not yet been systematically investigated in U.S. working populations, constituting a critical research gap that demands address. Our objective is to conduct secondary data analysis, in response to PAR-18-798, to better understand the relationship between long working hours and CVD mortality risk in the U.S., using data obtained from the National Health Interview Survey (NHIS) series of studies. The NHIS is an annually updated, large, nationally representative, and rich dataset featuring detailed information on demographics, working conditions, and health and disease status. The NHIS dataset represents a premiere opportunity to investigate the contribution of long working hours to excess CVD mortality. We propose to use the NHIS sample data from 1997- 2014 and the NHIS mortality data up to 2015 to examine associations between long working hours and CVD mortality, with a cumulative total of 18 years of follow-up. Our specific aims are to (1) investigate associations of long working hours with total CVD mortality; (2) investigate associations of long working hours with heart disease mortality as well as stroke mortality; and (3) test effect modification of demographic status (age, sex, race, region, and socioeconomic status (SES)) in the associations of long working hours with total CVD mortality, heart disease mortality, and stroke mortality, respectively. We hypothesize a dose-response relationship between long working hours and CVD mortality amongst the U.S. working population, and that this association will be modified by social and demographic characteristics. Our expected outputs and outcomes in the intermediate term anticipate the successful achievement of the specific aims, constituting the provision of high-quality, robust scientific evidence assessing the association of long working hours to CVD mortality in the U.S. This project has national and global relevance, and addresses goals set by the National Occupational Research Agenda (NORA) Health Work Design and Well-being sector and the NORA Cancer, Reproductive, Cardiovascular, and Other Chronic Disease Prevention cross-sectors. The ultimate long-term societal impact and contribution of this project would be to leverage such data to shape and inform interventional policy directives related to the limitation of working hours for the sake of CVD prevention. This represents a most critical opportunity in applying a Research to Practice (r2p) approach in reducing the occupational mortality burden of CVD.

抽象的 心血管疾病（CVD，包括心脏病和中风）是全球死亡的主要原因， 在美国（美国），仅2018年就会占280万人死亡，并且患病率接近50％.1,2 与此相关的工作时间很长，与其他国家相比，美国仍然很高。3,4 最近，一系列系统的评论和荟萃分析已经确定了强大的剂量依赖性 长期工作时间与CVD.5-9之间的关系，这些评论报告了工作超过55小时 一周与欧洲劳动力中CVD死亡率的风险更高有关。但是，这个关联 在美国的工作人群中尚未系统地研究 要求地址。我们的目标是对PAR-18-798进行辅助数据分析以更好 使用获得的数据，了解美国长期工作时间与CVD死亡率风险之间的关系 摘自《国家健康访谈调查》（NHIS）系列研究。 NHIS是每年更新的大型， 全国代表和丰富的数据集，其中包含有关人口统计，工作条件， 以及健康与疾病状况。 NHIS数据集代表了调查调查的首要机会 长期工作时间对过多的CVD死亡率的贡献。我们建议从1997年使用NHIS样本数据 - 2014年和NHIS死亡率数据截至2015年，以检查长期工作时间与CVD之间的关联 死亡率，累计总计18年的随访。我们的具体目的是（1）调查 总CVD死亡率长时间工作时间； （2）研究长期工作时间与心脏病的关联 死亡率和中风死亡率； （3）测试效果的修改人口统计状态（年龄，性别，种族，地区， 在长期工作时间与总CVD死亡率，心脏相关的关联中，社会经济地位（SES）） 疾病死亡率和中风死亡率。我们假设长时间之间的剂量反应关系 美国劳动人口中的工作时间和CVD死亡率，该协会将被修改 通过社会和人口特征。我们在中等学期中的预期产出和结果 预期特定目标的成功成就，构成高质量，健壮的提供 评估美国长期工作时间与CVD死亡率的关联的科学证据 国家和全球相关性，并解决国家职业研究议程（NORA）设定的目标 健康工作设计和福祉部门以及诺拉癌，生殖，心血管和其他 慢性疾病预防跨界。该项目的最终长期社会影响和贡献 将利用此类数据来塑造和告知与限制有关的介入的介入政策指令 为了预防CVD，工作时间。这是应用研究的最关键机会 实践（R2P）减少CVD职业死亡率燃烧的方法。