Personalised Adaptive Medicine

个性化适应性医学

• 批准号: 10100435
• 金额: $ 80.89万
• 依托单位: LOUGHBOROUGH UNIVERSITY
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10100435
• 关键词: Personalised; Adaptive; Medicine

Personalised drug formulation is a hot topic butstate of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing. The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised,segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practices such as GP’s office. PERAMEDIC will deliver a lab-scale proof-of-concept prototype system of the functionally combined novel technologies, with a preview design of the future technology.

个性化药物配方是一个热门话题，但最先进的方法受到低可扩展性、成本和监管障碍的限制，而当前的复方药丸配方工作受到液体形式或热熔添加方法的阻碍，带来了稳定性问题。价格，因为最近证明药物组合的协同作用可以显着改善治疗结果，同时将活性物质保持在理想的生理浓度范围内可以最大限度地提高效率并减少副作用。此外，多重用药是导致治疗结果的一个真正问题。最后，虽然大数据健康 IT 系统概念具有收集循证个性化医疗所需的大量可靠剂量患者数据的潜力，但提供此类数据的技术 - PERAMEDIC 项目提出通过突破性的解决方案来解决这些问题：用于个性化医疗的独立药物配方系统，提供本地准备、单独定制、分段的服务。发布该系统依赖于集成多种新技术：个人释放曲线、使用自适应工具路径的释放基质原位 3D 打印以及将药物超精确的多通道粉末剂量注入密封的微室中。是一台桌面大小的药丸/胶囊印刷机，使用粉状药物罐和生物可吸收聚合物基质材料。应用场景首先是临床环境，然后是药房地点和医疗实践，例如全科医生。 PERAMEDIC 将提供功能组合新技术的实验室规模概念验证原型系统，以及未来技术的预览设计。