Augmenting the Quality and Duration of the Immune Response with a Novel TLR2 Agonist-Aluminum Combination Adjuvant

使用新型 TLR2 激动剂-铝组合佐剂增强免疫反应的质量和持续时间

• 批准号: 10499193
• 负责人: LARRY BLASZCZAK
• 金额: $ 30万
• 依托单位: TEICHOS LABORATORIES, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2022-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10499193
• 关键词: Adjuvant; Agonist; Aluminum; Aluminum Hydroxide; Contractor; Development; Diphtheria; Diphtheria-Tetanus-acellular Pertussis Vaccines; Evaluation; Formulation; Goals; Immune; Immune response; In Vitro; Modification; Peptidoglycan; Performance; Pertussis; Production; Subunit Vaccines; TLR2 gene; Tetanus; Vaccine Adjuvant; Vaccine Antigen; absorption; aluminum sulfate; improved; in vivo evaluation; inorganic phosphate; novel; Adjuvant; Agonist; Aluminum; Aluminum Hydroxide; Contractor; Development; Diphtheria; Diphtheria-Tetanus-acellular Pertussis Vaccines; Evaluation; Formulation; Goals; Immune; Immune response; In Vitro; Modification; Peptidoglycan; Performance; Pertussis; Production; Subunit Vaccines; TLR2 gene; Tetanus; Vaccine Adjuvant; Vaccine Antigen; absorption; aluminum sulfate; improved; in vivo evaluation; inorganic phosphate; novel

The goal of this project is to optimize a novel adjuvant formulation composed of alum and a TLR2 agonist to improve performance of a DTaP subunit vaccine.

该项目的目的是优化由明矾和TLR2激动剂组成的新型辅助配方，以提高DTAP亚基疫苗的性能。