Biostatistics and Informatics Core

生物统计学和信息学核心

基本信息

批准号：
10493306
负责人：
Dipankar Bandyopadhyay
金额：
$ 12.03万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10493306
关键词：
Address Behavioral Bioinformatics Biometry Biostatistics Shared Resource Cancer Center Cancer Research Project Center for Translational Science Activities City of Hope Comprehensive Cancer Center Clinical Communities Computational algorithm Computerized Medical Record Control Groups DNA sequencing Data Databases Development Development Plans Doctor of Philosophy Educational Activities Ensure Epidemiology Experimental Designs Genomics Goals Human Resources Individual Informatics Institution Intervention Knowledge Location Logistics Malignant Neoplasms Malignant neoplasm of lung Manuscripts Medical Mentors Methodology Molecular NCI-Designated Cancer Center Outcome Outcome Study Pathology Population Prevention Principal Investigator Procedures Proteomics Protocols documentation Publications Quality Control Randomized Reporting Reproducibility Research Research Design Research Methodology Research Personnel Research Project Grants Research Support Resources Sample Size Scheme Secure Services Site South Carolina Statistical Data Interpretation Stratification Testing The Cancer Genome Atlas Time Training Translating Translational Research Universities Update Validation Vendor Virginia analytical tool biomedical informatics cBioPortal cancer health disparity career development central database cohort community engagement comparison group data integration data management data quality design experimental study firewall flexibility genomic data high dimensionality innovation interest mathematical model member novel research study social determinants sociodemographics success transcriptome sequencing web interface

项目摘要

BIOSTATISTICS AND BIOINFORMATICS CORE: PROJECT SUMMARY The overall objective of the TRACER Biostatistics and Bioinformatics Core (BBC) is to serve as the focal point from which the TRACER investigators and career development candidates can draw the much needed biostatistical, genomics, and biomedical informatics expertise needed for proper planning and execution of their research projects. These services include assisting in experimental design, study plan development, hypotheses refinement, database integration and access, data quality control, sample size requirements and power calculations, analysis of the statistical design, development of randomization and stratification procedures, interim analyses, analysis of completed results (which includes both biostatistical and genomics analyses), presentation of research findings, and scientific publication to disseminate new findings in the prevention and treatment of lung cancer. The BBC resource will be directed by Dr. Bandyopadhyay from VCU, with core personnel included across the three TRACER sites. To materialize the TRACER objectives, the BBC has proposed 3 specific aims, which broadly encompasses providing biostatistical and genomics analytics expertise (Aim 1), providing efficient data management, integration and distribution (Aim 2), and provide the much needed biostatistical training to TRACER investigators and community partners, as well as exploring novel advancements in biostatistical methodology in lung cancer (Aim 3). To achieve this, BBC personnel, in addition to their own research interactions with the TRACER members, can also call on additional assistance from various other biostatisticians, bioinformaticians, genomics experts, and senior statistical analysts with significant cancer expertise, all integrated within the respective Biostatistics Shared Resources at the NCI-designated cancer centers at VCU, MUSC, and CoH. The BBC thus constitute a tightly integrated component of the TRACER, and the services provided will add significant value to the realization of TRACER goals, which would not have been achieved through alternative vendors.

生物统计学和生物信息学核心：项目摘要 TRACER 生物统计和生物信息学核心 (BBC) 的总体目标是作为焦点 TRACER 调查员和职业发展候选人可以从中汲取急需的信息正确规划和执行其所需的生物统计、基因组学和生物医学信息学专业知识研究项目。这些服务包括协助实验设计、研究计划制定、假设细化、数据库集成和访问、数据质量控制、样本量要求和能力计算、统计设计分析、随机化和分层程序的开发，中期分析、完成结果分析（包括生物统计和基因组分析），介绍研究成果和科学出版物，以传播预防和预防方面的新发现肺癌的治疗。 BBC 资源将由 VCU 的 Bandyopadhyay 博士指导，核心内容为包括三个 TRACER 站点的人员。为了实现 TRACER 目标，BBC 已提出了 3 个具体目标，广泛涵盖提供生物统计和基因组学分析专业知识（目标1），提供高效的数据管理、集成和分发（目标2），并提供急需的为 TRACER 研究人员和社区合作伙伴提供生物统计培训，以及探索新颖的方法肺癌生物统计方法的进步（目标 3）。为了实现这一目标，BBC 人员还与 TRACER 成员进行自己的研究互动，还可以寻求来自各个方面的额外帮助其他患有重大癌症的生物统计学家、生物信息学家、基因组学专家和高级统计分析师专业知识，全部整合到 NCI 指定癌症的相应生物统计共享资源中 VCU、MUSC 和 CoH 中心。因此，BBC 构成了 TRACER 的一个紧密集成的组成部分，并且所提供的服务将为 TRACER 目标的实现增加重大价值，这是不可能的通过替代供应商实现。