Social security: The influence of social relationships on cognitive, affective, and neural aging

社会保障：社会关系对认知、情感和神经衰老的影响

基本信息

批准号：
10493358
负责人：
Mark G Baxter
金额：
$ 77.64万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10493358
关键词：
Address Affect Affective Age Aging Alzheimer&apos s Disease Animal Model Animals Autonomic nervous system Behavioral Biological Biological Factors Biology Brain Brain region California Cardiovascular Physiology Cognition Cognitive Data Dementia Deterioration Diabetes Mellitus Disease Emotional Emotions Goals Health Health Promotion Human Individual Intervention Laboratories Life Loneliness Longevity Macaca Macaca mulatta Measurement Measures Memory Mental Depression Meta-Analysis Modeling Monkeys Morbidity - disease rate Neurobiology Neurosecretory Systems Outcome Personal Satisfaction Persons Phase Population Primates Process Recovery Rejuvenation Research Rest Risk Short-Term Memory Social Environment Social Network Social Security Standardization Stimulus Stroke Structure Testing Time Visual Work age effect age group age related aged cognitive function cognitive testing effective intervention effective therapy emotional functioning experience functional MRI scan functional decline healthy aging human model immune function improved indexing life history memory recognition mortality neurobehavioral neuroimaging physical conditioning programs protective effect relating to nervous system response restoration social social group social influence social interventions social relationships social structure spatiotemporal unethical young adult

项目摘要

Project Summary Although accumulating evidence in humans points to improvements in emotional life with age, even in the context of physical and cognitive health challenges, the mechanisms that support those improvements are largely unknown. One possibility is that aspects of the social environment and social relationships guard against deleterious aging effects and thus promote wellbeing. Understanding the interplay between social environment and cognitive, affective, and neurobehavioral health outcomes across the lifespan is critical for developing effective interventions for people who suffer from the deleterious effects of aging, including depression and loneliness. Nevertheless, it is not ethical to manipulate humans’ social relationships in order to test causal hypotheses. To address this mechanistic question, we capitalize on a robust animal model of human social, cognitive, affective, and neurobehavioral aging – the rhesus monkey – in order evaluate whether robust social environments and high-quality relationships promote and protect healthy affective, cognitive, and neurobehavioral aging while restrictions of the social environment compromise it. Additionally, we evaluate whether social interventions, namely increasing access to high quality social partners, may improve cognitive, affective, and neurobehavioral outcomes once they have been compromised by aging processes. We will restrict and then rejuvenate the social environment in both young and aged monkeys, and measure neurobehavioral function (cognition, affect, and neuroimaging measures of brain structure and function) concurrently with these manipulations. In this way, this program of work represents a critical first step in determining the mechanistic impact of social environment on neurobehavioral aging in addition to evaluating a potential intervention that could benefit individuals who have experienced unhealthy aging.

项目概要尽管越来越多的人类证据表明情绪生活随着年龄的增长而改善，即使在这种情况下对于身体和认知健康的挑战，支持这些改善的机制主要是一种可能性是社会环境和社会关系方面的防范。有害的衰老影响，从而促进福祉。整个生命周期的认知、情感和神经行为健康结果对于发展至关重要对遭受衰老有害影响（包括抑郁症和抑郁症）的人们进行有效干预然而，为了检验因果关系而操纵人类的社会关系是不道德的。为了解决这个机械问题，我们利用了人类社会的强大动物模型，认知、情感和神经行为老化（恒河猴），以评估是否具有强大的社交能力环境和高质量的关系促进和保护健康的情感、认知和此外，我们还评估了神经行为老化，而社会环境的限制会损害它。社会干预措施，即增加获得高质量社会伙伴的机会是否可以改善，一旦情感和神经行为结果因衰老过程而受到损害，我们将对其进行限制。然后恢复年轻和年老猴子的社会环境，并测量神经行为功能（大脑结构和功能的认知、情感和神经影像测量）与这些同时进行通过这种方式，该工作计划代表了确定机械性能的关键的第一步。除了评估可能的潜在干预措施外，社会环境对神经行为衰老的影响使经历过不健康衰老的人受益。