A Puff Topography Biofeedback Paradigm to Reduce Stress-Precipitated Smoking Reinforcement

减少压力诱发的吸烟强化的抽吸地形生物反馈范例

• 批准号: 10491899
• 负责人: Samantha Gwen Farris
• 金额: $ 19.98万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491899
• 关键词: Acute; Address; Adult; Affect; Anxiety; Attention; Attenuated; Behavior; Behavioral; Biofeedback; Biofeedback Training; Biological; Blinded; Cardiac; Cigarette; Coping Skills; Development; Emotional; Emotions; Etiology; Expectancy; Familiarity; Female; Homeostasis; Impairment; Informal Social Control; Intervention; Intervention Studies; Laboratories; Link; Mediating; Mental disorders; Modeling; Nature; Outcome; Participant; Patient Self-Report; Population; Process; Protocols documentation; Psychological reinforcement; Psychophysiology; Randomized; Recovery; Research; Resistance; Rewards; Sinus; Smoke; Smoker; Smoking; Stress; Testing; Time; Tobacco; United States National Institutes of Health; Visit; addiction; base; behavioral phenotyping; biobehavior; cognitive process; comorbidity; craving; design; emotion regulation; emotional distress; health disparity; high reward; high risk; improved; improved outcome; in vivo monitoring; indexing; innovation; interest; novel; psychologic; respiratory; reward processing; satisfaction; sex; smoking cessation; substance use

PROJECT SUMMARY/ABSTRACT Smokers with emotional distress are particularly vulnerable to smoking reinforcement due to various biopsychological factors that contribute to deficits in emotion regulation and heightened reward processing, which undermine cessation efforts. The timing and intensity of one's puffing (i.e., puff topography) can titrate or maximize the cigarette's rewarding effect. Our group has identified puff topography as a core driver of smoking reinforcement, especially in emotionally distressed smokers. Although largely considered a behavioral phenotype of smoking reinforcement, inherent in puffing behavior are corresponding changes in cardiorespiratory parameters (e.g., cardiac vagal control, CVC) that may promote self-regulation and reduce craving. In our integrated psychophysiological model of emotional distress and smoking, we proposed that in smokers, impaired CVC not only implicates physiological homeostasis, but also influences addiction-relevant processes, including impaired higher-order cognitive processes needed for self-regulation and psychological functioning (e.g., reduced anxiety and stress).Yet, under certain time-sensitive contexts (e.g., stress), emotionally distressed smokers may puff in a way that enhances CVC, resulting in acute self-regulatory benefits, and in turn paradoxically amplifies the reinforcing value of each puff. Thus, a bio-behavioral intervention that could modify puff topography and CVC has the strong potential to reduce the reinforcing value of cigarettes in high-risk emotionally distressed smokers. Grounded in our biobehavioral framework, we designed a highly innovative bio-behavioral paradigm, called Puff Topography Biofeedback Training (PTBT) to directly target putative bio-behavioral underpinnings of smoking reinforcement (i.e., puffing topography and CVC). PTBT leverages in vivo monitoring of respiratory parameters (i.e., biofeedback) that occurs during smoking so that puffing is constrained to a pace that is designed to minimize CVC in order to attenuate acute self-regulatory, emotional, and craving reduction associated with smoking reinforcement. In this R1, we propose a between-subjects experimental test of PTBT and its ability to modify puff topography and CVC during stress-precipitated smoking, and in turn, reduce acute smoking reinforcement. Emotionally distressed daily smokers (N=88, 50% female) will be randomized to PTBT or Control; which are matched for time and attentional demand. Participants will complete two smoking trials on two successive days using either PTBT/Control. The first smoking trial (Visit 1) will allow participants to gain familiarity with the task. The second smoking trial (Visit 2) will be completed following acute laboratory stress induction (stress-precipitated smoking trial). The primary study aims are to test the effect of PTBT vs. Control, in terms of: acute changes in stress- precipitated smoking reinforcement (tobacco demand; cigarette reward; satisfaction) and changes in mechanisms (puff duration, CVC). The results of this high pre-intervention study could inform the subsequent development of a novel intervention strategy for improving quit outcomes in a treatment-resistant population.

项目摘要/摘要 由于各种 生物心理因素会导致情绪调节和奖励处理的不足， 这破坏了停止工作。一个人的浮肿的时机和强度（即泡芙地形）可以滴定或 最大化香烟的奖励效果。我们的小组已经确定了泡芙地形是吸烟的核心驱动力 加强，尤其是在情绪困扰的吸烟者中。虽然很大程度上是一种行为 吸烟加强的表型，浮肿行为固有的是相应的变化 心肺参数（例如心脏迷走神经对照，CVC）可能促进自我调节并减少 渴望。在我们情绪困扰和吸烟的综合心理生理模型中，我们提出了 吸烟者，CVC受损不仅牵涉到生理稳态，还影响与成瘾有关 过程，包括自我调节和心理所需的高阶认知过程受损 在某些时间敏感的环境（例如，压力）下，功能（例如，焦虑和压力减轻）.yet， 情绪困扰的吸烟者可能会以增强CVC的方式喘气，导致急性自我调节 益处又矛盾地放大了每个粉扑的增强价值。因此，是生物行为 可以修改粉扑地形和CVC具有降低增强价值的强大潜力的干预措施 在高风险的情绪困扰的吸烟者中的香烟。基于我们的生物行为框架，我们 设计了一种高度创新的生物行为范式，称为Puff地形生物反馈培训（PTBT） 直接针对假定的吸烟加固的生物行为基础（即膨化地形和 CVC）。 PTBT在体内监测呼吸参数（即生物反馈）中发生的利用 吸烟使浮肿被限制为旨在最小化CVC以减轻急性的速度 与吸烟增强相关的自我调节，情感和渴望减少。在这个R1中，我们 提出了PTBT的受试者间实验测试及其修改粉扑地形和CVC的能力 在压缩的吸烟期间，进而减少急性吸烟加强。情绪困扰 每日吸烟者（n = 88，50％女性）将被随机分为PTBT或对照；与时间匹配的 注意需求。参与者将连续两天完成两次吸烟试验 PTBT/控制。第一次吸烟试验（访问1）将使参与者能够熟悉任务。第二个 急性实验室压力诱导（压力活聚的吸烟）将完成吸烟试验（访问2） 审判）。主要研究目的是测试PTBT与控制的影响，以：应激的急性变化 - 促进吸烟加固（烟草需求；奖励奖励；满意度）和变化 机理（泡芙持续时间，CVC）。这项较高的干预前研究的结果可能会告知随后的 制定一种新的干预策略，以改善耐药人群中的戒烟结果。