A Puff Topography Biofeedback Paradigm to Reduce Stress-Precipitated Smoking Reinforcement

减少压力诱发的吸烟强化的抽吸地形生物反馈范例

基本信息

批准号：
10491899
负责人：
Samantha Gwen Farris
金额：
$ 19.98万
依托单位：
RUTGERS, THE STATE UNIV OF N.J.
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10491899
关键词：
Acute Address Adult Affect Anxiety Attention Attenuated Behavior Behavioral Biofeedback Biofeedback Training Biological Blinded Cardiac Cigarette Coping Skills Development Emotional Emotions Etiology Expectancy Familiarity Female Homeostasis Impairment Informal Social Control Intervention Intervention Studies Laboratories Link Mediating Mental disorders Modeling Nature Outcome Participant Patient Self-Report Population Process Protocols documentation Psychological reinforcement Psychophysiology Randomized Recovery Research Resistance Rewards Sinus Smoke Smoker Smoking Stress Testing Time Tobacco United States National Institutes of Health Visit addiction base behavioral phenotyping biobehavior cognitive process comorbidity craving design emotion regulation emotional distress health disparity high reward high risk improved improved outcome in vivo monitoring indexing innovation interest novel psychologic respiratory reward processing satisfaction sex smoking cessation substance use

项目摘要

PROJECT SUMMARY/ABSTRACT Smokers with emotional distress are particularly vulnerable to smoking reinforcement due to various biopsychological factors that contribute to deficits in emotion regulation and heightened reward processing, which undermine cessation efforts. The timing and intensity of one's puffing (i.e., puff topography) can titrate or maximize the cigarette's rewarding effect. Our group has identified puff topography as a core driver of smoking reinforcement, especially in emotionally distressed smokers. Although largely considered a behavioral phenotype of smoking reinforcement, inherent in puffing behavior are corresponding changes in cardiorespiratory parameters (e.g., cardiac vagal control, CVC) that may promote self-regulation and reduce craving. In our integrated psychophysiological model of emotional distress and smoking, we proposed that in smokers, impaired CVC not only implicates physiological homeostasis, but also influences addiction-relevant processes, including impaired higher-order cognitive processes needed for self-regulation and psychological functioning (e.g., reduced anxiety and stress).Yet, under certain time-sensitive contexts (e.g., stress), emotionally distressed smokers may puff in a way that enhances CVC, resulting in acute self-regulatory benefits, and in turn paradoxically amplifies the reinforcing value of each puff. Thus, a bio-behavioral intervention that could modify puff topography and CVC has the strong potential to reduce the reinforcing value of cigarettes in high-risk emotionally distressed smokers. Grounded in our biobehavioral framework, we designed a highly innovative bio-behavioral paradigm, called Puff Topography Biofeedback Training (PTBT) to directly target putative bio-behavioral underpinnings of smoking reinforcement (i.e., puffing topography and CVC). PTBT leverages in vivo monitoring of respiratory parameters (i.e., biofeedback) that occurs during smoking so that puffing is constrained to a pace that is designed to minimize CVC in order to attenuate acute self-regulatory, emotional, and craving reduction associated with smoking reinforcement. In this R1, we propose a between-subjects experimental test of PTBT and its ability to modify puff topography and CVC during stress-precipitated smoking, and in turn, reduce acute smoking reinforcement. Emotionally distressed daily smokers (N=88, 50% female) will be randomized to PTBT or Control; which are matched for time and attentional demand. Participants will complete two smoking trials on two successive days using either PTBT/Control. The first smoking trial (Visit 1) will allow participants to gain familiarity with the task. The second smoking trial (Visit 2) will be completed following acute laboratory stress induction (stress-precipitated smoking trial). The primary study aims are to test the effect of PTBT vs. Control, in terms of: acute changes in stress- precipitated smoking reinforcement (tobacco demand; cigarette reward; satisfaction) and changes in mechanisms (puff duration, CVC). The results of this high pre-intervention study could inform the subsequent development of a novel intervention strategy for improving quit outcomes in a treatment-resistant population.

项目概要/摘要由于各种原因，情绪困扰的吸烟者特别容易受到吸烟强化的影响。导致情绪调节缺陷和奖励处理增强的生物心理学因素，这破坏了戒烟努力。一个人抽吸的时间和强度（即抽吸地形）可以滴定或最大限度地提高香烟的奖励效果。我们的小组已确定抽吸地形是吸烟的核心驱动因素强化，特别是对于情绪困扰的吸烟者。虽然很大程度上被认为是一种行为吸烟强化的表型，吸烟行为所固有的，是相应的变化心肺参数（例如心脏迷走神经控制，CVC）可能促进自我调节并减少渴望。在我们的情绪困扰和吸烟的综合心理生理学模型中，我们提出吸烟者的 CVC 受损不仅会影响生理稳态，还会影响与成瘾相关的行为过程，包括自我调节和心理所需的受损高阶认知过程功能（例如，减少焦虑和压力）。然而，在某些对时间敏感的情况下（例如，压力），情绪低落的吸烟者可能会以增强 CVC 的方式吸烟，从而导致严重的自我调节好处，反过来又放大了每一口的强化价值。因此，生物行为可以改变粉扑地形的干预措施和 CVC 具有降低增强值的强大潜力情绪困扰的高风险吸烟者的香烟数量。基于我们的生物行为框架，我们设计了一种高度创新的生物行为范式，称为泡芙地形生物反馈训练（PTBT）直接针对吸烟强化的假定生物行为基础（即吸烟地形和 CVC）。 PTBT 利用体内监测呼吸过程中发生的呼吸参数（即生物反馈）吸烟，以便将吸气速度限制在旨在最大限度地减少 CVC 的速度，以减轻急性发作与吸烟强化相关的自我调节、情绪和渴望减少。在这个R1中，我们提出 PTBT 及其修改粉扑地形和 CVC 能力的受试者间实验测试在压力诱发吸烟期间，反过来又减少急性吸烟强化。情绪困扰每日吸烟者（N = 88，50% 女性）将被随机分配至 PTBT 组或对照组；与时间和注意力需求。参与者将使用以下任一方法在连续两天内完成两项吸烟试验 PTBT/控制。第一次吸烟试验（访问 1）将使参与者熟悉该任务。第二个吸烟试验（访视 2）将在急性实验室应激诱导（应激诱发吸烟）后完成审判）。主要研究目的是测试 PTBT 与对照相比，在以下方面的效果：压力的急剧变化突然的吸烟强化（烟草需求；香烟奖励；满意度）和变化机制（抽吸持续时间、CVC）。这项高干预前研究的结果可以为后续研究提供信息制定一种新的干预策略，以改善治疗抵抗人群的戒烟结果。