HTORR High Priority Alzheimer's Disease and Related Dementias Human Biospecimen Resource

HTORR 高优先级阿尔茨海默氏病和相关痴呆症人类生物样本资源

• 批准号: 10489968
• 负责人: Thomas J Bell
• 金额: $ 32.14万
• 依托单位: NATIONAL DISEASE RESEARCH INTERCHANGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10489968
• 关键词: Address; Administrative Supplement; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Autopsy; Award; Awareness; Biological Models; Biomedical Research; Blood; Brain; Caregivers; Case Study; Cerebrovascular Disorders; Collaborations; Collection; Communication; Communities; Complement; Complex; Custom; Data; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Eligibility Determination; Etiology; Exhibits; Experimental Designs; Experimental Models; Feedback; Functional disorder; Funding; Geography; Goals; Grant; Health Services Accessibility; Healthcare Systems; Human; Human Activities; Hypertension; Investigation; Liquid substance; Methodology; Methods; Modeling; National Institute on Aging; Neurodegenerative Disorders; Neurologic; Obesity; Organ; Organ Procurements; Parents; Pathogenesis; Pathology; Patients; Play; Principal Investigator; Procedures; Protocols documentation; Provider; Race; Recommendation; Recording of previous events; Recovery; Reproducibility; Research; Research Personnel; Research Priority; Resources; Sampling; Scientific Advances and Accomplishments; Scientist; Services; Site; Source; Standardization; Tissue Banks; Tissue Sample; Tissues; Training; United States National Institutes of Health; Universities; biobank; body system; cohort; diagnostic strategy; effective therapy; experimental analysis; human tissue; improved; interest; invention; nervous system disorder; neuropathology; outreach; preservation; programs; recruit; screening; sex; success; symposium; tissue resource; translational study; treatment strategy; web site; Address; Administrative Supplement; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Autopsy; Award; Awareness; Biological Models; Biomedical Research; Blood; Brain; Caregivers; Case Study; Cerebrovascular Disorders; Collaborations; Collection; Communication; Communities; Complement; Complex; Custom; Data; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Eligibility Determination; Etiology; Exhibits; Experimental Designs; Experimental Models; Feedback; Functional disorder; Funding; Geography; Goals; Grant; Health Services Accessibility; Healthcare Systems; Human; Human Activities; Hypertension; Investigation; Liquid substance; Methodology; Methods; Modeling; National Institute on Aging; Neurodegenerative Disorders; Neurologic; Obesity; Organ; Organ Procurements; Parents; Pathogenesis; Pathology; Patients; Play; Principal Investigator; Procedures; Protocols documentation; Provider; Race; Recommendation; Recording of previous events; Recovery; Reproducibility; Research; Research Personnel; Research Priority; Resources; Sampling; Scientific Advances and Accomplishments; Scientist; Services; Site; Source; Standardization; Tissue Banks; Tissue Sample; Tissues; Training; United States National Institutes of Health; Universities; biobank; body system; cohort; diagnostic strategy; effective therapy; experimental analysis; human tissue; improved; interest; invention; nervous system disorder; neuropathology; outreach; preservation; programs; recruit; screening; sex; success; symposium; tissue resource; translational study; treatment strategy; web site

Program Director/Principal Investigator (Last, First, Middle): Bell, Thomas, J. Project Summary: The development of effective treatments or cures for a wide range of diseases requires translational studies that are directly relevant to human pathophysiology. The use of human biospecimens plays a key role in accelerating scientific discoveries in neurological research by providing scientists with a direct experimental model system to advance understanding of pathogenesis and treatment of neurological disease, including Alzheimer’s disease and related dementias (AD/ADRD). To address several complex issues facing AD/ADRD research, including disease etiology as well as the development of improved diagnostics and treatment strategies, investigators require access to a unique human tissue resource that could provide rigorous and uniform collection of human biospecimens from defined cohorts of post mortem AD/ADRD and normal control donors to yield consistent and reproducible experimental results for inventive and groundbreaking studies. As a leading human tissue provider for the biomedical research community, the National Disease Research Interchange (NDRI) is a 501(c)(3), not- for-profit organization that remains at the forefront of coordinating biospecimen procurement to match the needs of advancing scientific experimental methodologies, enabling cutting-edge research. For over 30 years, NDRI has received NIH funding for the parent award to this administrative supplement, the Human Tissue and Organs for Research Resource (HTORR) Grant Number: U420DO11158. To address the high priority areas of research for AD/ADRD that require both post mortem biospecimen collection that are beyond the scope of HTORR, NDRI is expanding their capabilities to create a new resource, the AD/ADRD Human Biospecimen Resource (ADBR), funded by the active award 3U42OD011158-30S1. In Program Year 3 of the ADBR, NDRI continued to follow the recommendations from ADBR Advisory Council regarding biospecimen collection and distribution for the ADBR that align with an unmet or under represented need in the field. For the current proposal to continue the progression of the ADBR, NDRI proposes to enhance the success of ADBR’s service to investigators in PY4 by 1) providing a nationwide network of TSS to provide access to diverse post mortem diseased and non-diseased donor cohorts, 2) recovering and distributing CNS tissues in addition to other tissues and fluids of interest, and 3) enhancing communication to the biomedical research community to recruit new ADBR investigators and assess unmet needs of the AD/ADRD field. In contrast to similar resources, the ADBR’s extensive outreach efforts and customized approach to investigator needs are key differentiators for the resource. Collectively, the ADBR’s goals and efforts provides a dynamic and synergistic NIH-funded resource to support the advancement of critical unmet research needs for the AD/ADRD research community. Relevance: As the most common cause of dementia, AD is a devastating, progressive neurodegenerative disease that affects over 5.7 million Americans (Alzheimer’s Association et al, 2018) and has a significant burden on the US healthcare system as well as caregivers. As of yet, there are no disease-modifying treatment options available for AD/ADRD patients, making this a high priority for the research community. The objective of this proposal is to provide biospecimens from post mortem AD/ADRD donors, as well as non- diseased control donors for the AD/ADRD Human Biospecimen Resource (ADBR) that are suitable to support critical lines of investigation that address high priority needs and key issues in the field. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

计划主任/首席研究员（最后，第一，中间）：贝尔，托马斯，J。 项目摘要： 开发各种疾病的有效疗法或治疗方法需要翻译研究 与人类病理生理学直接相关。人类生物测量的使用在加速方面起着关键作用 神经研究中的科学发现，通过为科学家提供直接的实验模型系统 提前了解神经疾病的发病机理和治疗，包括阿尔茨海默氏病 和相关痴呆症（AD/ADRD）。解决广告/ADRD研究面临的几个复杂问题，包括 疾病病因以及改进的诊断和治疗策略的发展，研究人员 需要访问独特的人体组织资源，该资源可以提供严格而统一的人类收集 来自验尸后的AD/ADRD和正常对照捐赠者的生物测量，以产生一致和 可再现的实验结果，用于发明和开创性研究。作为领先的人类组织提供者 对于生物医学研究界，国家疾病研究互换（NDRI）是501（c）（3），而不是 营利性组织仍然处于协调生物环境采购的最前沿，以满足需求 推进科学实验方法，从而实现尖端研究。 30多年来，NDRI 已获得该行政补品，人体组织和器官的父母奖的NIH资金 用于研究资源（HTORR）赠款编号：U420DO11158。解决研究的高优先级领域 对于AD/ADRD，需要验收后生物循环收集，这些收集超出了HTORR，NDRI的范围 正在扩大其创建新资源的能力，广告/ADRD人类生物循环资源（ADBR）， 由Active Award 3U42OD011158-30S1资助。在ADBR的第3年计划中，NDRI继续遵循 ADBR咨询委员会关于生物循环收集和分销的建议 与该场中未满足或未经代表的需求对齐的ADBR。目前的提议继续 ADBR的进展，NDRI提出的提案，以增强ADBR为PY4中调查人员提供成功的成功。 1）提供全国性TSS网络，以提供验收于Mortem后的潜水 捐助者队列，2）除了其他感兴趣的组织和流体外，还恢复和分发中枢神经系统组织 3）加强与生物医学研究界的沟通，以招募新的ADBR研究者和 评估AD/ADRD字段的未满足需求。与类似资源相反，ADBR的广泛宣传 努力和调查员需求的定制方法是资源的关键差异化者。 总体而言，ADBR的目标和努力为NIH资助的动态和协同的资源提供了 支持AD/ADRD研究社区的关键未满足研究需求的促进。 相关性：作为痴呆症的最常见原因，AD是毁灭性的，进行性神经退行性的 影响超过570万美国人的疾病（阿尔茨海默氏症协会等人，2018年） 美国医疗保健系统和护理人员的负担。到目前为止，尚无疾病修改 可用于广告/ADRD患者的治疗选择，这是研究界的高优先事项。 该提案的目的是提供Mortem AD/ADRD捐赠者以及非 - 适用于支持的AD/ADRD人类生物循环资源（ADBR）的解除控制供体 解决高优先级需求和现场关键问题的关键投资线。 OMB No. 0925-0001/0002（Rev. 03/2020通过02/28/2023批准）页面延续格式页面