Core 2: Biostatistics and Bioinformatics

核心2：生物统计学和生物信息学

基本信息

批准号：
10480087
负责人：
JEFFREY S MORRIS
金额：
$ 25.15万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-25 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10480087
关键词：
Address Basic Science Bioinformatics Biometry Clinical Research Clinical Sciences Conduct Clinical Trials Data Data Analyses Data Analytics Data Set Development Ensure Fibrosis Genomics Goals Laboratory Research Lateral Logistics Malignant neoplasm of liver Methodology Methods Molecular Morbidity - disease rate Paper Pathway interactions Primary carcinoma of the liver cells Publications Publishing Reporting Reproducibility Research Research Design Research Personnel Resources Statistical Data Interpretation Techniques Translational Research University of Texas M D Anderson Cancer Center Validation Work analytical tool archive data archived data base biomarker signature career computerized data processing data acquisition data handling data management design experience experimental study innovation member metabolomics models and simulation mortality novel novel marker preclinical study programs statistical service success

项目摘要

Core 2: Biostatistics and Bioinformatics - SUMMARY/ ABSTRACT The primary goal of the University of Texas MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma (HCC) is to facilitate innovative translational research through the elucidation of underlying molecular mechanisms, characterizing novel biomarkers and functional pathways, and exploiting novel targets for treatment. This is a collaborative effort that will accomplish these aims by integrating laboratory and translational research. The Biostatistics and Bioinformatics Core will serve multiple needs for the planning and conduct of the SPORE's research. Based on a strong track record for providing biostatistical and computational support for translational research, Core 2 will be a comprehensive, multi-lateral resource for designing clinical and basic science experiments, performing statistical analyses, developing innovative statistical methodology, and publishing the research results generated from this HCC SPORE. Core 2 will provide guidance in the design and conduct of clinical trials and other experiments arising from the ongoing research of the SPORE, including SPORE projects, Developmental and Career Enhancement projects, and other cores. Core 2 will also provide biostatistical and bioinformatic modeling, simulation techniques and data analyses needed by the Projects and other Cores to achieve their Specific Aims. Core 2 will generate statistical reports for all projects, will assist project investigators to publish scientific results and will develop innovative statistical and bioinformatics methods pertinent to translational HCC studies including new unsupervised approaches to biomarker signature construction.

核心 2：生物统计学和生物信息学 - 摘要/摘要德克萨斯大学 MD 安德森癌症中心 SPORE 在肝细胞癌方面的主要目标（HCC）旨在通过阐明潜在分子来促进创新转化研究机制，表征新的生物标志物和功能途径，并开发新的靶标治疗。这是一项协作努力，将通过整合实验室和转化研究。生物统计学和生物信息学核心将满足规划和生物信息学的多种需求。 SPORE 研究的进行。基于提供生物统计和数据的良好记录为转化研究提供计算支持，Core 2 将成为一个全面的、多边的资源设计临床和基础科学实验，进行统计分析，开发创新统计方法，并发布 HCC SPORE 产生的研究结果。核心2将为正在进行的临床试验和其他实验的设计和进行提供指导 SPORE 研究，包括 SPORE 项目、发展和职业提升项目，以及其他核心。 Core 2 还将提供生物统计和生物信息学建模、模拟技术和数据项目和其他核心实现其具体目标所需的分析。核心2将生成统计数据所有项目的报告，将协助项目研究人员发布科学成果并开发创新与转化性 HCC 研究相关的统计和生物信息学方法，包括新的无监督方法生物标志物签名构建方法。