The Developing Brain: Influences and Outcomes

发育中的大脑：影响和结果

基本信息

批准号：
10475650
负责人：
Viren Andrew D'Sa
金额：
$ 40.48万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475650
关键词：
Address Adolescent Adult Affect Age Behavior Behavior Disorders Behavioral Birth Body Composition Body mass index Brain Brain imaging Caring Child Child Nutrition Childhood Clinical Cognition Cognition Disorders Cognitive Collection Complex Conceptions Cross-Sectional Studies DNA Data Data Set Databases Development Disease Elements Environment Environmental Exposure Environmental Risk Factor Event Exposure to Family history of Fetal Development Fetal Growth Retardation Foundations Future Genetic Genetic Polymorphism Genotype Growth Growth Factor Growth and Development function Health Heterogeneity Human Characteristics Image Individual Infant Intervention Learning Life Link Longitudinal Studies Magnetic Resonance Imaging Maps Masks Measurement Measures Mediating Mental Health Mental disorders Modeling Neurocognitive Neurodegenerative Disorders Neurologic Nutritional Outcome Pattern Police Population Premature Birth Process Public Health Research Design Shapes Sleep Statistical Methods Statistical Models Structure Symptoms Techniques Update Variant Visit base behavioral outcome brain behavior brain shape cognitive development cognitive skill cohort deciduous tooth early childhood early life exposure experience fecal microbiome fetal genetic risk factor gut microbiome holistic approach improved in utero infancy insight lead exposure longitudinal analysis microbiome model development multimodality myelination neural network neurobehavioral neurodevelopment neuroimaging nutrition obesity in children oral microbiome physical conditioning postnatal pressure recruit response serial imaging skills sleep health sociodemographics success synaptic pruning synaptogenesis

项目摘要

PROJECT SUMMARY / DESCRIPTION How does our healthy brain grow? The simplicity of this question masks the highly complex and multifaceted nature of human neurodevelopment. Across fetal development, infancy and early childhood, our brain undergoes remarkable change in response to diverse genetic and environmental pressures. Processes including myelination and synaptogenesis are at their peak across the first 2-3yrs of life, contributing to the emergence of nearly all cognitive and behavioral skills, and laying the foundation for future learning and academic success. While the importance of this early life period to life-long mental health is widely recognized, important questions remain regarding the influences that shape brain growth and cognitive development: 1. How is brain growth altered by specific pre- and post-natal environmental or genetic factors; 2. How are patterns of brain growth associated with, and predictive of, emerging cognitive and behavioral abilities; and 3. How are these brain-behavior relationships influenced by modifiable factors experienced throughout childhood? This proposal seeks to address these fundamental questions using a unique longitudinal neuroimaging dataset that spans fetal, infant and childhood development (22wks to 10yrs of age) and contains more than 2500 measures from ~650 children with diverse birth outcomes, environmental exposures and genotypes. Alongside multimodal MRI, extensive neurocognitive, sociodemographic, physical health, family and medical history, anthropometric, nutrition, sleep, and biospecimen (DNA, oral and fecal microbiome, and shed deciduous teeth) data have been collected on each child and updated at biannual or annual visits. Using this extensive dataset, we aim to address our central hypothesis: that intrauterine events, early life environmental exposures and genetic factors influence cognitive/behavioral outcomes by altering patterns of brain growth. We will examine this hypothesis in three incremental steps. First, we will demonstrate that intrauterine events, early life exposures and specific genetic polymorphisms give rise to altered trajectories of brain development. Next, we will show that differing patterns of neurodevelopment are associated with varying cognitive and behavioral profiles. Finally, we will take a holistic approach and examine how modifiable factors, specifically child nutrition and obesity, sleep health, and our microbiome may mediate these brain-cognition/behavior relationships within the context of related pre- and post-natal environmental and genetic influences. This marks a distinct departure from prior studies, which have typically examined these factors in relative isolation and using cross-sectional study designs. Over the course of this proposal, an additional 500 children will be recruited and 3000 longitudinal measures acquired (bringing the totals to ~1100 children and ~6100 measures). This represents the largest pediatric neuroimaging database that spans birth to 10yrs, and the only that includes fetal and infant measures on the same children. This study and dataset, therefore, represent an unprecedented opportunity to examine the diverse influences, and their complex interactions, that shape brain growth across a fundamental yet understudied period of development.

项目摘要 /描述我们健康的大脑如何增长？这个问题的简单性掩盖了高度复杂且多方面的人类神经发育的本质。在胎儿发育，婴儿期和幼儿期，我们的大脑对各种遗传和环境压力的响应，经历了显着的变化。过程包括髓鞘形成和突触发生在其跨越生命的前2-3岁之间，有助于几乎所有认知和行为技巧的出现，并为将来的学习奠定基础学术上的成功。尽管这个早期生命时期对终身心理健康的重要性得到了广泛认可，但关于塑造大脑生长和认知发展的影响的重要问题：1。大脑生长会因特定的产前和产后环境或遗传因素而改变； 2。如何与新兴的认知和行为能力相关并预测的大脑生长；和3。如何这些大脑行为关系受整个儿童期经历的可修改因素的影响？这提案旨在使用独特的纵向神经影像学数据集解决这些基本问题跨越胎儿，婴儿和儿童期发展（22周至10岁年龄），并包含2500多种措施来自约650名具有不同出生结果，环境暴露和基因型的儿童。与多模式一起 MRI，广泛的神经认知，社会人口统计学，身体健康，家庭和病史，人体测量学，营养，睡眠和生物循环（DNA，口服和粪便微生物组以及落叶牙齿）的数据已经是收集每个孩子，并每年一次或年度访问更新。使用这个广泛的数据集，我们的目标是解决我们的中心假设：宫内事件，早期生活环境暴露和遗传因素通过改变大脑生长的模式来影响认知/行为结果。我们将在三个增量步骤。首先，我们将证明宫内事件，早期生活暴露和特定遗传多态性导致大脑发育的轨迹改变。接下来，我们将证明不同的神经发育的模式与不同的认知和行为概况有关。最后，我们会接受一种整体方法，并研究如何修改因素，特别是儿童营养和肥胖，睡眠健康和我们的微生物组可以在相关前和产后环境和遗传影响。这标志着与先前的研究明显不同，通常以相对隔离和使用横截面研究设计检查了这些因素。在课程中在该提案中，将招募另外500名儿童，并获得3000个纵向措施（带来总计约1100名儿童和约6100个措施）。这代表了最大的儿科神经影像学数据库跨越了10年，唯一包括同一儿童的胎儿和婴儿措施。这项研究因此，数据集代表了一个前所未有的机会来检查各种影响及其复杂的相互作用，塑造了在基本但经过研究的发展时期的大脑生长。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.

DOI：
10.1126/sciadv.adi0497
发表时间：
2023-12-22
期刊：
SCIENCE ADVANCES
影响因子：
13.6
作者：
Bonham, Kevin S.;Bottino, Guilherme Fahur;McCann, Shelley Hoeft;Beauchemin, Jennifer;Weisse, Elizabeth;Barry, Fatoumata;Lorente, Rosa Cano;Huttenhower, Curtis;Bruchhage, Muriel;D'Sa, Viren;Deoni, Sean;Klepac-Ceraj, Vanja
通讯作者：
Klepac-Ceraj, Vanja

A New Approach for Functional Connectivity via Alignment of Blood Oxygen Level-Dependent Signals