Neuroimaging approaches to improve prediction of smoking initiation and nicotine use escalation among young adult electronic nicotine delivery systems users

神经影像学方法可改善年轻成人电子尼古丁输送系统用户吸烟开始和尼古丁使用升级的预测

• 批准号: 10474992
• 负责人: Jiaying Liu
• 金额: $ 18.09万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-07-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474992
• 关键词: Address; Adult; Awareness; Back; Behavior assessment; Behavioral; Brain; Communication; Competence; Complement; Cotinine; Crossover Design; Cues; Data; Dependence; Desire for food; Development; Electronic Mail; Electronic Nicotine Delivery Systems; Emotions; Epidemic; Evaluation; Exhalation; Food; Functional Magnetic Resonance Imaging; Goals; Grant; Health Campaign; Intervention; Link; Liquid substance; Maintenance; Marketing; Measures; Mediating; Nature; Neurocognitive; Neurosciences; Neurosciences Research; Nicotine; Nicotine Dependence; Outcome; Palate; Participant; Patient Self-Report; Persons; Policies; Predisposition; Prevention; Process; Psychological reinforcement; Public Health; Randomized Controlled Trials; Recommendation; Regulation; Reporting; Research; Research Personnel; Research Training; Rewards; Risk; Risk Assessment; Risk Factors; Risk Marker; Safety; Services; Severities; Smoke; Smoker; Smoking; Stimulus; Surveys; System; Testing; Time; TimeLine; Tobacco; Tobacco use; Training; Translating; Urine; Visit; Visual; Vulnerable Populations; Writing; addiction; aerosolized; career development; cigarette smoke; cigarette smoking; cognitive control; communication behavior; craving; cue reactivity; design; experience; high risk population; improved; incentive salience; indexing; neurobehavioral; neuroimaging; never smoking; nicotine use; non-smoking; novel; outcome prediction; predictive marker; primary outcome; relating to nervous system; research study; resilience; response; risk prediction; smoking initiation; substance use; success; tobacco control; tobacco flavor; tobacco prevention; tobacco products; tobacco regulatory science; vaper; vaping; young adult

PROJECT SUMMARY/ABSTRACT The proposed career development application provides research training for Dr. Jiaying Liu to facilitate her transition to independence. The goal of the proposed research is to identify neurobehavioral makers of nicotine use escalation and cigarette smoking initiation among young adult (YA) users of electronic nicotine delivery systems (ENDS). Findings are expected to inform regulatory policy and improve YA responsiveness to public health campaign communications. Given the accumulating evidence that ENDS use conveys 5-fold additional risk for smoking initiation and other tobacco use escalation, recent YA increases in use are alarming, threatening a resurgence of dependence that may reverse decades of tobacco control success. Therefore, it is crucial to identify predictive markers of smoking initiation and tobacco use escalation in this vulnerable population, and to provide actionable evidence that informs regulatory and prevention efforts. Functional magnetic resonance imaging (fMRI) generates information complementary to traditional behavioral risk assessments, with direct observations of the neural substrates that underlie the subjective states known to perpetuate addiction, in order to yield objective and putatively more predictive measures. Assessment of behavioral and brain markers associated with smoking onset and tobacco use escalation is proposed. The goal is to determine whether baseline neurobehavioral markers will predict smoking transition and tobacco use escalation beyond traditional makers at 3, 6, 9 and 12 months. A one-year public service announcement (PSA) intervention with a cross-over design will also be conducted, in which two message exposure orders and one control condition allow testing whether novel anti-ENDS PSAs addressing harms associated with ENDS flavors will more effectively prevent tobacco use escalation compared to the existing regular PSAs. The proposed research is among the first that aims to inform regulation of flavored ENDS marketing, and to provide recommendations for developing effective PSAs for prevention campaigns. These aims directly address multiple priorities of FDA Center for Tobacco Products (Marketing Influences, Communications, Behavior and Addiction), and they are expected to pinpoint effective regulatory gates to address the current ENDS epidemic. Dr. Liu’s long-term goal is to become an independent researcher translating communication neuroscience research to regulatory actions for improvements in health campaigns and interventions utilizing persuasive anti-tobacco messaging. Her near-term goal is to prepare a competitive R01 application to implement randomized controlled trials of PSAs to maximize impact on deterrence of smoking and substance use transition among ENDS users. The proposed training experience is designed to develop competencies in (a) neuroscience, (b) functional neuroimaging, (c) tobacco regulatory science, and (d) grant writing. The proposed research study provides focus for training and preliminary data to support a competitive R01 application.

项目摘要/摘要 拟议的职业发展应用程序为Jiaying Liu博士提供了研究培训，以促进她 过渡到独立。拟议的研究的目的是确定尼古丁的神经行为制造者 在电子尼古丁传递的年轻人（YA）使用者中使用升级和吸烟计划 系统（末端）。期望调查结果将为监管政策提供信息，并提高对公众的响应能力 健康运动通讯。鉴于累积的证据表明使用的证据传达了5倍额外的证据 吸烟计划和其他烟草使用升级的风险，最近使用的YA增加令人震惊， 威胁着依赖的复兴，这可能会逆转数十年的烟草控制成功。因此，是 在此脆弱的 人口，并提供可行的证据，以告知监管和预防工作。功能 磁共振成像（fMRI）生成传统行为风险的信息完成 评估，直接观察神经底物，这些神经底物是已知的主观状态的基础 永久成瘾，以产生客观和推定的预测性测量。评估 提出了与吸烟发作和烟草使用升级相关的行为和大脑标记。目标 是确定基线神经行为标记是否可以预测吸烟过渡和烟草使用 在3、6、9和12个月以外的传统制造商以外的升级。为期一年的公共服务公告（PSA） 还将进行跨界设计的干预，其中两个消息暴露订单和一个 控制条件允许测试新型抗末端是否解决与末端风味相关的危害的PSA 与现有的常规PSA相比，将更有效地防止烟草使用升级。提议 研究是第一个旨在告知火花市场营销并提供的研究 为预防运动开发有效PSA的建议。这些目的直接解决 FDA烟草产品中心的多个优先事项（营销影响，沟通，行为和 成瘾），预计它们可以确定有效的监管门以解决当前目的的流行。 刘博士的长期目标是成为一名独立研究人员，翻译神经科学 研究对健康运动和干预措施改善的监管行动的研究 反烟草消息传递。她的近期目标是准备有竞争力的R01应用程序以实施 PSA的随机对照试验，以最大程度地影响吸烟和吸烟的影响 最终用户之间的过渡。拟议的培训经验旨在发展（a）中的能力 神经科学，（b）功能性神经影像学，（c）烟草监管科学和（d）授予写作。提议 研究研究提供了培训和初步数据的重点，以支持竞争性R01应用程序。