Core B: Omics and Bioinformatics Core MSU COBRE Phase II

核心 B：组学和生物信息学核心 MSU COBRE II 期

• 批准号: 10470187
• 负责人: Bindu Nanduri
• 金额: $ 20.66万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470187
• 关键词: Address; Adoption; Atmosphere; Bioinformatics; Biological; Biomedical Research; Biotechnology; Centers of Research Excellence; Communities; Data; Data Analyses; Educational process of instructing; Ensure; Equipment; Funding; Genomics; Goals; Human Resources; Individual; Infectious Diseases Research; Infrastructure; Institutes; Interdisciplinary Study; Lead; Mass Spectrum Analysis; Metabolism; Mississippi; Modeling; Phase; Pilot Projects; Proteomics; Research; Research Personnel; Research Project Grants; Resources; Services; Systems Biology; Techniques; Technology; United States National Institutes of Health; Universities; University resources; Virulence; Work; base; biocomputing; bioinformatics resource; experience; experimental study; genome-wide; high throughput analysis; insight; instrument; instrumentation; metabolomics; novel; pathogen; programs; success; transcriptome sequencing; virtual

Project Summary The Center of Biomedical Research Excellence (COBRE) Phase I, Pathogen-Host Interactions at Mississippi State University (MSU) successfully incorporated the MSU Institute for Genomics, Biocomputing and Biotechnology (IGBB) as part of a systems biology Core B. Core B services provide access to expertise, instrumentation, biocomputing and bioinformatics necessary for generating and analyzing high throughput omics data. The goals of the Omics and Bioinformatics Core B in this COBRE Phase II application are to 1) build on the technical and intellectual infrastructure gains made in COBRE Phase I, and 2) continue to provide service and expertise in an effective and responsive manner to meet the critical needs of COBRE Phase II Lead Investigators. To expand omics capabilities at MSU to meet COBRE Phase II investigator needs in metabolomics, we propose to integrate the existing instrumentation and resources at MSU from different departments and institutes (located physically within a mile) into a ‘virtual’ Omics and Bioinformatics Core (Core B). Therefore, the Objective of Core B is to continue integrating and building on existing equipment and personnel into the COBRE atmosphere not only to make access more efficient for COBRE investigators but also to stimulate biomedical research at MSU in general. This will be accomplished through three specific aims: 1. Provide an administrative mechanism to ensure COBRE investigators access to instrumentation, and expertise for conducting omics research, such as proteomics, RNA-Seq and metabolomics as well as biocomputing and bioinformatics. 2. Enhance existing infrastructure, stability, and sustainability of omics technologies required for COBRE projects. 3. Provide technologies and analytical support required by Phase II COBRE investigators. Omics and Bioinformatics Core B will make significant contribution towards COBRE sustainability as it provides services in genome scale technologies that are at the forefront of the biomedical research enterprise. COBRE Phase II Core B will build on the success in of Phase I and enable COBRE Investigators to develop the thematic multidisciplinary research focus into a functioning, productive biomedical research center.

项目摘要 生物医学研究卓越中心（COBRE）第一阶段，密西西比州的病原体宿主相互作用 州立大学（MSU）成功地纳入了MSU基因组学研究所，生物计算和 生物技术（IGBB）作为系统生物学核心B的一部分B。核心B服务提供专业知识的访问， 仪器，生物计算和生物信息学对于生成和分析高吞吐量的数量 数据。在此毛线II期应用程序中，OMICS和BioInformitics核心B的目标是1）建立 I阶段I和2）继续提供服务的技术和智力基础设施收益 并以有效而响应的方式专业知识，以满足COBRE II期铅的关键需求 调查人员。扩大MSU的OMICS功能以满足COBRE II期研究者的需求 代谢组学，我们建议通过不同的不同 部门和机构（物理位于一英里范围之内）中的“虚拟”幻象和生物信息学核心（核心） b）。因此，核心B的目的是继续集成和建立现有的设备和人员 进入山脉气氛，不仅是为了使毛毛调查人员更有效，而且还可以 一般来说，在MSU刺激生物医学研究。这将通过三个特定目标来完成：1。 提供一种行政机制，以确保毛绒调查人员获得仪器和专业知识 用于进行OMICS研究，例如蛋白质组学，RNA-SEQ和代谢组学以及生物计算和 生物信息学。 2。增强OMICS技术的现有基础架构，稳定性和可持续性 毛绒项目。 3。提供第二阶段毛线研究者要求的技术和分析支持。 OMICS和BioInformatics核心B将为毛绒可持续性做出重大贡献，因为它提供了 在生物医学研究企业的最前沿的基因组量表技术中的服务。鞋垫 II阶段核心B将基于第一阶段的成功，并使毛毛比调查人员能够发展主题 多学科研究集中于功能性的生物医学研究中心。