Occupational transitions across the lifecourse and dementia risk: evaluating unemployment, occupational complexity using sequence analysis

生命历程中的职业转变和痴呆风险：使用序列分析评估失业、职业复杂性

• 批准号: 10468988
• 负责人: Anusha Murthy Vable
• 金额: $ 78.91万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10468988
• 关键词: Address; Adult; Age; Alzheimer' s Disease; American; Behavioral; Calibration; Cause of Death; Censuses; Characteristics; Classification; Code; Cognitive; Computers; Data; Data Set; Dementia; Diagnosis; Dictionary; Digit structure; Disease; Education; Elderly; Employment; Etiology; Gender; Geography; Goals; Health; Health and Retirement Study; Impaired cognition; Incidence; Income; Individual; Information Networks; Information Services; Intervention; Job loss; Life Experience; Literature; Maternity leave; Methodology; Modification; National Longitudinal Survey of Youth; Nature; Occupational; Occupations; Patient Self-Report; Pattern; Persons; Population; Process; Publishing; Race; Research; Respondent; Risk Factors; Scholarship; Sequence Analysis; Social Environment; Social Network; Surveys; System; Testing; Time; Unemployment; United States; Work; base; career; cohort; data harmonization; dementia risk; disorder risk; experience; instrument; longitudinal database; middle age; novel; panel study of income dynamics; population based; response; social; social determinants; sociodemographic factors; spelling; theories

PROJECT ABSTRACT Dementia is typically diagnosed in late life, however, the disease process begins decades earlier; mid-life experiences such as work are important modifiable predictors of Alzheimer's Disease and related disorders (ADRD). Work is central to the lives of American adults, but the relationship between work, unemployment, and ADRD across the lifecourse has been understudied. This proposal advances the current literature on how occupations influence dementia risk in the United States in two ways: [1] people work from approximately ages 18 – 65, however little research evaluates age when someone has a particular job, job duration, or changes in work experiences across working years; and [2] occupational classification systems used by population-based datasets have changed to reflect the transition from a manufacturing to information and service based economy (with different physical, environmental, and cognitive demands), however physical, environmental, and cognitive characteristics of work have not been systematically applied to these shifting occupational classification systems. In this proposal, we will evaluate lifecourse work trajectories and ADRD risk through novel applications of sequence analysis, and construct a longitudinal database of physical, environmental, and cognitive demands of work to catalyze research on lifecourse work trajectories and ADRD risk. We will leverage the strengths of three large, longitudinal U.S. cohorts to evaluate the relationships between lifecourse work trajectories and ADRD risk: The National Longitudinal Survey of Youth, 1979 cohort (NLSY), the Panel Study of Income Dynamic (PSID), and the Health and Retirement Study (HRS). Our research team has previously published using sequence analysis, and previously used all three datasets, demonstrating the feasibility of our proposed project. Work is a modifiable social risk factor that spans decades; a better understanding of work trajectories and features will help identify employment interventions to slow cognitive decline and reduce ADRD disparities.

项目摘要 痴呆症通常在后期诊断出来，但是，疾病过程开始较早开始。 诸如工作之类的经验是对阿尔茨海默氏病和相关疾病的重要修改预测指标 （ADRD）。 在整个生命程度中，该提议都被研究了。 职业以两种方式影响美国的痴呆症风险：[1]人们从大概开始工作是GE 18-65，但是很少的研究评估了某人的特定工作，工作持续时间或变化的年龄 跨处理工的工作经验 数据集已更改以反映从制造业到基于信息和服务经济的过渡 （有不同的身体，环境和认知需求），霍弗身体，环境和认知能力 工作的特征尚未系统地应用于转移的职业分类系统。 在此提案中，我们将通过新的应用程序来评估生命力的工作轨迹和ADRD风险 序列分析，并构建物理的纵向数据库和认知要求 催化生命力的研究轨迹和ADRD风险的工作。 大型的，纵向的美国人群评估生命力的工作轨迹与ADRD风险之间的关系： 1979年的全国青年纵向调查（NLSY） 健康与退休研究（HRS）以前已经使用序列出版 工作是一个 跨越数十年的可修改社会风险因素； 帮助确定就业互动以减缓认知能力下降并减少ADRD差异。