FASEB SRC: Matricellular Proteins: Fundamental Concepts and New Directions

FASEB SRC：基质细胞蛋白：基本概念和新方向

• 批准号: 10468385
• 负责人: Kurt David Hankenson
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468385
• 关键词: Academia; Adhesions; Aging; Apoptosis; Arthritis; Binding; Biological Process; Biology; Cardiovascular Diseases; Career Mobility; Cartilage; Categories; Cell Adhesion; Cell Adhesion Process; Cell Communication; Cell Cycle Progression; Cell Proliferation; Cell Surface Receptors; Cell physiology; Cell surface; Cells; Collaborations; Collagen; Communities; Complex; Cysteine; Development; Disease; Educational workshop; Environment; Extracellular Matrix; Extracellular Matrix Proteins; Extracellular Protein; Family; Family member; Fostering; Future; Gene Expression; Gene Family; Goals; Government; Growth Factor; Growth and Development function; Industry; Infection; Inflammation; Left; Ligaments; Malignant Neoplasms; Mechanics; Mentorship; Metabolism; Molecular; Musculoskeletal System; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural regeneration; Non-Insulin-Dependent Diabetes Mellitus; Organ; Osteoporosis; Pathologic; Pathology; Peptide Hydrolases; Phenotype; Physiological Processes; Portugal; Protein Family; Proteins; Reactive Oxygen Species; Receptor Cell; Regulation; Research; Research Personnel; Retinal Degeneration; Role; Scientist; Set protein; Signal Transduction; Skin; Structure; Tenascin; Tendinopathy; Tendon structure; Thrombospondins; Time; Tissues; Universities; Washington; Work; bone; career development; cell growth regulation; cytokine; design; fibulin; functional group; meetings; member; migration; periostin; posters; receptor; repaired; response; symposium; trait; Academia; Adhesions; Aging; Apoptosis; Arthritis; Binding; Biological Process; Biology; Cardiovascular Diseases; Career Mobility; Cartilage; Categories; Cell Adhesion; Cell Adhesion Process; Cell Communication; Cell Cycle Progression; Cell Proliferation; Cell Surface Receptors; Cell physiology; Cell surface; Cells; Collaborations; Collagen; Communities; Complex; Cysteine; Development; Disease; Educational workshop; Environment; Extracellular Matrix; Extracellular Matrix Proteins; Extracellular Protein; Family; Family member; Fostering; Future; Gene Expression; Gene Family; Goals; Government; Growth Factor; Growth and Development function; Industry; Infection; Inflammation; Left; Ligaments; Malignant Neoplasms; Mechanics; Mentorship; Metabolism; Molecular; Musculoskeletal System; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural regeneration; Non-Insulin-Dependent Diabetes Mellitus; Organ; Osteoporosis; Pathologic; Pathology; Peptide Hydrolases; Phenotype; Physiological Processes; Portugal; Protein Family; Proteins; Reactive Oxygen Species; Receptor Cell; Regulation; Research; Research Personnel; Retinal Degeneration; Role; Scientist; Set protein; Signal Transduction; Skin; Structure; Tenascin; Tendinopathy; Tendon structure; Thrombospondins; Time; Tissues; Universities; Washington; Work; bone; career development; cell growth regulation; cytokine; design; fibulin; functional group; meetings; member; migration; periostin; posters; receptor; repaired; response; symposium; trait

Matricellular proteins (MPs) are key component proteins of the extracellular matrix that are integral to modulating cell physiology. Through binding to cellular receptors, growth factors, and other ECM components this functional group of proteins regulates development and growth, regeneration, pathology, cancer, and aging. MPs are broadly expressed in many tissues, and have recognized roles in a variety of disease/pathological conditions, including, arthritis, osteoporosis, tendinopathy, type II diabetes, cardiovascular disease, retinal degeneration, cancer and metasis. We are seeking support for the 7th triennial FASEB SRC matricellular protein conference, titled “Matricelluar Proteins: Fundamental Concepts and New Directions”. The focus of this meeting which will be held in the summer of 2022 is to bring together a diverse group of established and new investigators. Our goal is to rediscover what it means for a protein to be considered a matricellular protein, and to lay a path to define the future of the field. While there are a set of proteins that are considered prototypical matricellular proteins, many new proteins that are secreted and multifunctional can also be considered MP. Considering these new proteins in the framework of the matricellular concept can help new investigators to advance their research. A plenary session will kick-off the meeting and will include a keynote speaker. This session will introduce the concepts of cell adhesion, growth factor binding, adhesion-de- adheision, and matrix-matrix interactions – canonical functions that define matricellular proteins. Over the subsequent four days, two sessions per day, each day will be focused on expanding one of these concepts. Morning sessions will focus on the aforementioned concepts, and the afternoon sessions will be focused on protein family specific presentations. Wednesday will include a 2nd keynote speaker. While most of the invited speakers and all of the session chairs have been invited and committed, we have left open speaker slots in most sessions in order to invite ‘up and coming’ scientists – trainee and early-stage investigators – with exciting new work over the next 6 months. We will request abstract submissions and two abstracts will be selected from each submitted abstract for presentation in six of the nine sessions and then there will be two poster sessions. Additional career development activities will include mentorship/mentee opportunities, career development workshops, and MP specific question/answer sessions. The organizers have been and will continue to be highly focused on fostering an inclusive environment. Both new investigators to the field and long-standing members of the MP community will attend the meeting and actively participate in this meeting, and be drawn from academia, government, and industry.

母细胞蛋白（MPS）是细胞外基质的关键成分蛋白，它们是不可或缺的 调节细胞生理。通过与细胞接收器，生长因子和其他ECM成分结合 该功能蛋白的功能群调节发展和生长，再生，病理，癌症和 老化。 MP在许多组织中广泛表达，并且在多种 疾病/病理状况，包括关节炎，骨质疏松症，肌腱病，II型糖尿病，心血管 疾病，残留变性，癌症和过渡。我们正在寻求支持第七三年faseb src 母细胞蛋白会议，标题为“矩阵蛋白：基本概念和新方向”。 这次会议的重点将于2022年夏季举行 成立和新的调查员。我们的目标是重新发现蛋白质被认为是什么意思 母细胞蛋白，并为定义田间的未来铺路。虽然有一组蛋白质 被认为是原型基质蛋白，许多分泌和多功能的新蛋白 也被视为MP。在基质概念的框架内考虑这些新蛋白质可以帮助 新的调查人员推进他们的研究。全体会议将启动会议，并将包括 主题演讲者。本次会议将介绍细胞粘合剂，生长因子结合，粘合剂 - 粘合剂的概念 ADHEISION和矩阵矩阵相互作用 - 定义基质蛋白的规范函数。在 随后的四天，每天两次会议，每天将重点放在扩展这些概念之一上。 上午会议将重点放在优先提到的概念上，下午会议将重点放在 蛋白质家族特定的演示。星期三将包括第二个主题演讲者。而大多数邀请 演讲者和所有会议椅都被邀请并承诺，我们将开放式扬声器插槽留在 大多数会议是为了邀请“启动”科学家 - 学员和早期调查员 - 令人兴奋的新作品在接下来的6个月中。我们将要求摘要提交，两个摘要将是 从每个提交的摘要中选择的九个会话中的六个中的介绍，然后将有两个 海报会议。额外的职业发展活动将包括指导/指导机会，职业 开发研讨会和国会议员特定的问题/答案。 组织者已经并且将继续高度专注于培养包容性环境。两个都 该领域的新调查人员和国会议员社区的长期成员将参加会议， 积极参加这次会议，并从学术界，政府和工业界吸引。