The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center

俄亥俄州立大学慢性胰腺炎糖尿病胰腺癌 (CPDPC) 临床中心

基本信息

批准号：
10471651
负责人：
DARWIN LEWIS CONWELL
金额：
$ 9.45万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10471651
关键词：
Abdominal Pain Address Adult Aliquot Ancillary Study Applications Grants Artificial Intelligence Basic Science Big Data Methods Biological Biological Markers Cancer Research Infrastructure Childhood Clinical Cancer Center Clinical Sciences Clinical Trials Collaborations Collection Complement Cross-Sectional Studies Data Data Collection Development Diabetes Mellitus Digestive System Disorders Disease Enrollment Epidemiology Evaluation Exocrine pancreas Exocrine pancreatic insufficiency Fibrosis Fostering Functional disorder Funding Future Goals Grant Inflammation Infrastructure Institutes Institution Interdisciplinary Study Kidney Diseases Lead Leadership Malignant neoplasm of pancreas Malnutrition Manuscripts Medical Research National Cancer Institute Natural History Observational Study Ohio Pancreas Participant Patients Positioning Attribute Process Progress Reports Protocols documentation Publications Research Research Infrastructure Research Personnel Services Ships Tissues Universities chronic pain chronic pancreatitis clinical center diagnostic biomarker follow-up insight novel organizational structure predictive marker repository response working group

项目摘要

ABSTRACT The mechanistic underpinnings of diseases involving the exocrine pancreas are poorly understood. Chronic pancreatitis is often accompanied by inflammation of the pancreas, irreversible fibrosis, and destruction of the pancreatic parenchyma resulting in abdominal pain, malnutrition, exocrine pancreatic insufficiency, pancreatogenic diabetes, and, in some cases, pancreas cancer. We have developed a network of adult and pediatric investigators to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Clinical Centers (CPDPC-CCs) (U01), the OSU CC has helped develop four (4) major observational studies during the initial funding cycle to address research gaps in our understanding of diseases of the exocrine pancreas. Specifically, the OSU CC seeks to validate proposed diagnostic biomarkers in chronic pancreatitis, pancreatogenic diabetes, and pancreas cancer.

抽象的人们对涉及外分泌胰腺的疾病的机制基础知之甚少。慢性的胰腺炎常伴有胰腺炎症、不可逆纤维化和胰腺组织破坏。胰腺实质导致腹痛、营养不良、胰腺外分泌功能不全、胰源性糖尿病，在某些情况下，还有胰腺癌。我们已经开发了一个成人和儿科研究人员组建俄亥俄州立大学临床中心 (OSU CC)。在多学科与慢性胰腺炎、糖尿病研究联盟的其他临床中心合作胰腺癌临床中心 (CPDPC-CC) (U01)，OSU CC 已帮助开发了四 (4) 个主要在初始资助周期内进行观察性研究，以解决我们对疾病理解的研究差距外分泌胰腺。具体来说，OSU CC 寻求验证提议的诊断生物标志物慢性胰腺炎、胰源性糖尿病和胰腺癌。