Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking

酒精和大麻共同使用对主观酒精反应和饮酒问题的人际和人内影响

• 批准号: 10462319
• 负责人: Jack T Waddell
• 金额: $ 4.54万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462319
• 关键词: Acute; Address; Affective; Alcohol abuse; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Arousal; Cannabis; Collaborations; Data; Dizziness; Drunk driving; Ecological momentary assessment; Event; Faculty; Feeling; Fellowship; Goals; Heavy Drinking; Impulsivity; Individual; Intervention; Intoxication; Measures; Mediating; Mediation; Mediator of activation protein; Mentors; Methodology; Methods; Modeling; Outcome; Participant; Pattern; Persons; Positioning Attribute; Reporting; Research; Research Personnel; Rewards; Risk; Risk Factors; Sexual Development; Statistical Data Interpretation; Telephone; Testing; Time; Training; Work; alcohol consequences; alcohol effect; alcohol misuse; alcohol response; alcohol risk; alcohol use disorder; base; brief intervention; career; data management; design; drinking; experience; follow up assessment; novel; preventable death; programs; response; tenure track

Project Abstract: The proposed fellowship seeks to identify whether subjective alcohol response (i.e., acute affective and intoxicating effects) serve as both between-person and within-person mechanisms of risk through which alcohol and cannabis co-use is related to heavier drinking and negative consequences. The applicant's long- term career goal is to obtain a tenure-track faculty position with a research program focused on the dynamic interplay among co-use, subjective response, and impulsivity as predictors of problem drinking. This fellowship will enable the applicant to gain expertise in subjective response to co-use, advanced quantitative analyses, as well as Ecological Momentary Assessment (EMA) data management and organization. This fellowship will also enable the applicant to develop and strengthen fruitful collaborations with leaders in the field of co-use, subjective response, and EMA methods. The current training plan features a highly skilled mentoring team with expertise in subjective alcohol response (Dr. William Corbin), advanced quantitative analyses (Dr. Kevin Grimm), subjective response to cannabis/co-use (Dr. Jane Metrik), and EMA methods of co-use (Drs. Christine Lee and Timothy Trull). The proposed project will use data from an ongoing EMA study that captures event- level data on subjective response to moments of co-use (vs. alcohol-only use), as well as same-night drinking quantity and negative consequences via a novel phone application (TigerAware). The proposed study will test 1) whether co-users (vs. alcohol-only users) endorse heightened between-person levels of subjective response (i.e., acute affective and intoxicating effects), 2) whether event-level co-use (vs. alcohol-only use) is associated with heightened within-person levels of subjective response, and 3) whether subjective response mediates the within-person effect of event-level co-use (vs alcohol-only use) on heavier drinking and negative consequences aggregated to the day-level. Participants (Current N=115; Target N=130) will come from a 21-day EMA study, in which they were asked to fill out a morning report, two afternoon reports, and three nightly reports. Participants were asked to initiate a drink report when drinking, which had follow-up assessments that replaced concurrent random reports at that time. Co-use of alcohol and cannabis was assessed during drink reports, acute subjective response was assessed during drink reports, and past-night drinking quantity and negative consequences were assessed during next-day morning reports. The proposed study will be the first to test both between-person and within-person differences in subjective response based upon co-use. It will also be the first to differentiate co-use “subjective intoxication” from several subjective response domains, which is vital to understand which acute effects are enhanced or exacerbated by co-use. Findings will inform brief interventions by better understanding 1) between-person risk factors for alcohol misuse to tailor via broad-level interventions, and 2) within-person risk factors to target via just-in-time interventions seeking to reduce alcohol misuse on riskier (i.e., co-use) days.

项目摘要： 拟议的奖学金旨在确定主观酒精反应是否（即急性情感和 令人陶醉的效果）是人际关系和人际风险机制 酒精和大麻共同使用与较重的饮酒和负面后果有关。申请人的长期 任期职业目标是获得统治轨道的职位，其研究计划的重点是动态 共同使用，主观反应和冲动性的相互作用，作为饮酒问题的预测指标。这个奖学金 将使申请人能够获得对共同使用，高级定量分析的主观响应的专业知识， 以及生态瞬时评估（EMA）数据管理和组织。这个奖学金也将 使申请人能够与共同利用领域的领导人建立富有成果的合作， 主观响应和EMA方法。当前的培训计划由一支高技能的心理团队与 主观酒精反应的专业知识（William Corbin博士），高级定量分析（Kevin博士 Grimm），对大麻/共同使用（Jane Metrik博士）的主观反应，以及EMA的共同使用方法（Christine博士 Lee和Timothy Trull）。拟议的项目将使用正在进行的EMA研究中的数据捕获事件 - 关于共同利用矩的主观响应的水平数据（与酒精的使用）以及同一夜喝酒 通过新颖的电话应用程序（Tigeraware）造成数量和负面后果。拟议的研究将测试 1）同事（仅与酒精的用户）是否认可人之间的主观响应水平 （即，急性情感和陶醉的效果），2）事件级共同使用（与酒精的使用）是否相关 随着主观反应的个人内部水平的提高，3）主观反应是否介导 事件级共同使用（与酒精的使用）对较重饮酒和负面后果的人体内部效果 汇总到日级。参与者（当前n = 115;目标n = 130）将来自21天EMA研究， 他们被要求填写早上的报告，两个下午的报告和三份夜间报告。 饮酒时要求参与者发起饮料报告，然后进行了随后的评估。 当时并发随机报告。在饮料报告中评估酒精和大麻的共同使用， 在饮料报告中评估了急性主观反应，以及过去的饮酒量和阴性 在第二天早晨的报告中评估了后果。拟议的研究将是第一个测试 基于共同利用的主观反应中的人际关系和人内部差异。也将是 首先将共同使用的“主观内部效用”与几个主观响应域区分开来，这对于 了解通过共同利用增强或加剧哪些急性效应。调查结果将为您提供简短的干预措施 通过更好地理解1）滥用酒精的人之间的风险因素，以通过广泛的级别量身定制 干预措施，以及2）通过及时的干预措施来减少酒精的人身内风险因素 滥用风险（即共同使用）天。