Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking
酒精和大麻共同使用对主观酒精反应和饮酒问题的人际和人内影响
基本信息
- 批准号:10462319
- 负责人:
- 金额:$ 4.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAffectiveAlcohol abuseAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholsArousalCannabisCollaborationsDataDizzinessDrunk drivingEcological momentary assessmentEventFacultyFeelingFellowshipGoalsHeavy DrinkingImpulsivityIndividualInterventionIntoxicationMeasuresMediatingMediationMediator of activation proteinMentorsMethodologyMethodsModelingOutcomeParticipantPatternPersonsPositioning AttributeReportingResearchResearch PersonnelRewardsRiskRisk FactorsSexual DevelopmentStatistical Data InterpretationTelephoneTestingTimeTrainingWorkalcohol consequencesalcohol effectalcohol misusealcohol responsealcohol riskalcohol use disorderbasebrief interventioncareerdata managementdesigndrinkingexperiencefollow up assessmentnovelpreventable deathprogramsresponsetenure track
项目摘要
Project Abstract:
The proposed fellowship seeks to identify whether subjective alcohol response (i.e., acute affective and
intoxicating effects) serve as both between-person and within-person mechanisms of risk through which
alcohol and cannabis co-use is related to heavier drinking and negative consequences. The applicant's long-
term career goal is to obtain a tenure-track faculty position with a research program focused on the dynamic
interplay among co-use, subjective response, and impulsivity as predictors of problem drinking. This fellowship
will enable the applicant to gain expertise in subjective response to co-use, advanced quantitative analyses, as
well as Ecological Momentary Assessment (EMA) data management and organization. This fellowship will also
enable the applicant to develop and strengthen fruitful collaborations with leaders in the field of co-use,
subjective response, and EMA methods. The current training plan features a highly skilled mentoring team with
expertise in subjective alcohol response (Dr. William Corbin), advanced quantitative analyses (Dr. Kevin
Grimm), subjective response to cannabis/co-use (Dr. Jane Metrik), and EMA methods of co-use (Drs. Christine
Lee and Timothy Trull). The proposed project will use data from an ongoing EMA study that captures event-
level data on subjective response to moments of co-use (vs. alcohol-only use), as well as same-night drinking
quantity and negative consequences via a novel phone application (TigerAware). The proposed study will test
1) whether co-users (vs. alcohol-only users) endorse heightened between-person levels of subjective response
(i.e., acute affective and intoxicating effects), 2) whether event-level co-use (vs. alcohol-only use) is associated
with heightened within-person levels of subjective response, and 3) whether subjective response mediates the
within-person effect of event-level co-use (vs alcohol-only use) on heavier drinking and negative consequences
aggregated to the day-level. Participants (Current N=115; Target N=130) will come from a 21-day EMA study,
in which they were asked to fill out a morning report, two afternoon reports, and three nightly reports.
Participants were asked to initiate a drink report when drinking, which had follow-up assessments that replaced
concurrent random reports at that time. Co-use of alcohol and cannabis was assessed during drink reports,
acute subjective response was assessed during drink reports, and past-night drinking quantity and negative
consequences were assessed during next-day morning reports. The proposed study will be the first to test both
between-person and within-person differences in subjective response based upon co-use. It will also be the
first to differentiate co-use “subjective intoxication” from several subjective response domains, which is vital to
understand which acute effects are enhanced or exacerbated by co-use. Findings will inform brief interventions
by better understanding 1) between-person risk factors for alcohol misuse to tailor via broad-level
interventions, and 2) within-person risk factors to target via just-in-time interventions seeking to reduce alcohol
misuse on riskier (i.e., co-use) days.
项目摘要:
拟议的研究金旨在确定主观酒精反应(即急性情感和
中毒效应)既可以作为人与人之间的风险机制,也可以作为人内部的风险机制,通过这种机制
酒精和大麻的共同使用与酗酒和负面后果有关。
学期职业目标是获得终身教职,其研究项目专注于动态研究
共同使用、主观反应和冲动之间的相互作用作为问题饮酒的预测因素。
将使申请人能够获得对共同使用的主观反应、高级定量分析的专业知识,例如
以及生态瞬时评估(EMA)数据管理和组织。
使申请人能够与共同使用领域的领导者发展和加强富有成效的合作,
主观反应和 EMA 方法 当前的培训计划拥有一支高技能的指导团队,
主观酒精反应方面的专业知识(William Corbin 博士)、高级定量分析(Kevin 博士)
Grimm)、对大麻/共同使用的主观反应(Jane Metrik 博士)和 EMA 共同使用方法(Christine 博士)
Lee 和 Timothy Trull)。拟议的项目将使用正在进行的 EMA 研究的数据,该研究捕获事件 -
关于共同使用时刻(与仅饮酒)以及当晚饮酒的主观反应的水平数据
拟议的研究将通过新型手机应用程序(TigerAware)进行测试。
1)共同使用者(相对于仅饮酒的使用者)是否认可人与人之间的主观反应水平
(即,急性情感和醉酒效应),2)事件级共同使用(与仅饮酒相比)是否相关
具有愉快的人内主观反应水平,以及3)主观反应是否介导
事件级共同使用(与仅饮酒相比)对酗酒和负面后果的个人影响
参与者(当前 N=115;目标 N=130)将来自为期 21 天的 EMA 研究,
其中要求他们填写一份上午报告、两份下午报告和三份夜间报告。
参与者被要求在饮酒时启动一份饮酒报告,该报告的后续评估取代了
当时的同时随机报告在饮酒报告期间评估了酒精和大麻的共同使用,
在饮酒报告中评估急性主观反应,以及昨晚饮酒量和阴性
拟议的研究将是第一个对这两种情况进行测试的研究。
基于共同使用的人与人之间和人内部的主观反应差异也将是。
首先将共同使用的“主观中毒”与几个主观反应领域区分开来,这对于
了解共同使用会增强或加剧哪些急性影响 研究结果将为简短的干预措施提供信息。
通过更好地了解 1) 人与人之间酗酒的风险因素,通过广泛的层面进行定制
干预措施,以及 2) 通过寻求减少饮酒的及时干预措施来针对人体内的风险因素
在风险较大(即共同使用)的日子里滥用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Jack T Waddell', 18)}}的其他基金
Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking
酒精和大麻共同使用对主观酒精反应和饮酒问题的人际和人内影响
- 批准号:
10633117 - 财政年份:2022
- 资助金额:
$ 4.54万 - 项目类别:
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