Intergenerational impact of maternal trauma history on preschoolers' behavioral health outcomes: Assessing links with caregiving sensitivity and DNA methylation

产妇创伤史对学龄前儿童行为健康结果的代际影响：评估与护理敏感性和 DNA 甲基化的联系

• 批准号: 10462734
• 负责人: Archana Basu
• 金额: $ 57.33万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-08 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10462734
• 关键词: 4 year old; Accounting; Address; Adolescent; Adult; Adverse event; Affect; Automobile Driving; Behavior; Birth; Characteristics; Child; Child Abuse and Neglect; Child Behavior; Child Health; Childbirth; Childhood; Chronic; DNA Methylation; Data; Development; Epigenetic Process; First Pregnancy Trimester; Funding; Generations; Genes; Gestational Age; Goals; Grant; Health; Health behavior; High Prevalence; Infant; Intervention; Life Cycle Stages; Link; Literature; Live Birth; Longitudinal cohort; Mediating; Mental Depression; Methodology; Modeling; Mothers; National Institute of Child Health and Human Development; Outcome; Peruvian; Policies; Post-Traumatic Stress Disorders; Pregnancy; Pregnant Women; Problem behavior; Psychopathology; Public Health; Recording of previous events; Regulation; Reporting; Research; Research Design; Risk; Role; Salivary; Sample Size; Sampling; Shapes; Skin; Stress; System; Testing; Time; Trauma; Violence; Woman; Work; base; behavioral health; behavioral outcome; biobehavior; biological systems; caregiving; cohort; design; early childhood; experience; externalizing behavior; follow-up; generalized anxiety; high risk; intergenerational; intimate partner violence; maltreated children; maternal caregiving; modifiable risk; offspring; postnatal; prepregnancy; preventive intervention; prospective; protective effect; protective factors; recruit; theories

PROJECT SUMMARY Background: This study seeks to better understand maternal trauma history as a driver of behavior health problems in 4-year-old children. We will examine the impact of maternal trauma across four time periods 1) maternal experience of pre-pregnancy abuse in childhood (when mothers < 18 years), 2) maternal experience of pre-pregnancy of abuse in adulthood, 3) maternal experience of abuse during pregnancy, and 4) maternal report of postnatal abuse (after childbirth to time of assessment) on their children’s behavioral problems (internalizing and externalizing behaviors). Using a lifecourse theory approach within an intergenerational context, we will test three models to determine whether the effect of maternal trauma 1) depends on the timing of exposure (Sensitive Period model); or 2) is strongest when it is most proximal to the child outcome examined (Recency model); or 3) increases with the number of exposures (Accumulation model). A primary study aim is to investigate how “experience gets under the skin” by examining associations between maternal trauma history with children’s salivary DNA methylation (DNAm) profiles. Finally, we will test whether the effects of maternal trauma history on child health outcomes are mediated by children’s salivary DNAm profiles and maternal caregiving sensitivity. Study Design: Building on an existing prospective longitudinal cohort of Peruvian women, recruited in the first trimester of pregnancy, established as part of a prior NICHD-funded grant (n = 4,472 live births), the study has well-characterized data on maternal trauma history, maternal lifetime psychopathology, and extensive data on birth outcomes. This sample has a high prevalence of childhood maltreatment, intimate partner violence, and other traumas (88% report at least one trauma and 30% report 3 or more traumas), and psychopathology (e.g., 33% PTSD, 26% depression, and 33% generalized anxiety). We will collect follow-up data on a subset of mother-child dyads (n=1,700). Implications: By examining modifiable risk (maternal trauma history) and protective factors (maternal caregiving sensitivity), particularly in sensitive periods of development, and by determining whether and how these factors impact biological systems, this study can inform future research and interventions to address the significant intergenerational public health burden of trauma.

项目摘要 背景：本研究试图更好地理解母体创伤历史作为行为健康的驱动力 4岁儿童的问题。我们将研究四个时期的物物创伤的影响1） 童年（母亲<18岁时）的孕妇怀孕虐待经验，2）孕产妇经验 成年后的虐待前怀孕，3）怀孕期间的虐待经验，4） 关于孩子的行为问题的产后虐待报告（分娩后至评估时间） （内部化和外部化行为）。在代际中使用生命力理论方法 上下文，我们将测试三个模型，以确定母体创伤的影响1）取决于时间 暴露（敏感时期模型）；或2）当它最靠近孩子的结果时很强 检查（新近度模型）；或3）随着暴露次数的数量（累积模型）增加。主要 研究目的是通过检查母亲之间的关联来研究“经验在皮肤下的经验” 儿童唾液DNA甲基化（DNAM）概况的创伤史。最后，我们将测试是否 孕产妇创伤史对儿童健康结果的影响是由儿童的唾液DNAN介导的 和孕产妇的敏感性。研究设计：建立在现有的前瞻性纵向队列的基础上 秘鲁妇女是在怀孕的头三个月招募的，作为先前的NICHD资助的一部分 Grant（n = 4,472个活产），该研究具有有关母体创伤病史的特征良好的数据 心理病理学以及有关出生结果的广泛数据。该样本的童年患病率很高 虐待，亲密伴侣暴力和其他创伤（88％的报告至少有1次创伤和30％的报告3 或更多的创伤）和心理病理学（例如33％的PTSD，26％的抑郁症和33％的广义动画）。我们 将收集有关母子二元组子集的后续数据（n = 1,700）。含义：检查可修改 风险（母亲创伤病史）和受保护因素（母体护理敏感性），特别是在敏感方面 开发时期，以及确定这些因素是否以及如何影响生物系统，这 研究可以告知未来的研究和干预措施，以解决重要的代际公共卫生 创伤负担。