Intergenerational impact of maternal trauma history on preschoolers' behavioral health outcomes: Assessing links with caregiving sensitivity and DNA methylation

产妇创伤史对学龄前儿童行为健康结果的代际影响：评估与护理敏感性和 DNA 甲基化的联系

• 批准号: 10462734
• 负责人: Archana Basu
• 金额: $ 57.33万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-08 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10462734
• 关键词: 4 year old; Accounting; Address; Adolescent; Adult; Adverse event; Affect; Automobile Driving; Behavior; Birth; Characteristics; Child; Child Abuse and Neglect; Child Behavior; Child Health; Childbirth; Childhood; Chronic; DNA Methylation; Data; Development; Epigenetic Process; First Pregnancy Trimester; Funding; Generations; Genes; Gestational Age; Goals; Grant; Health; Health behavior; High Prevalence; Infant; Intervention; Life Cycle Stages; Link; Literature; Live Birth; Longitudinal cohort; Mediating; Mental Depression; Methodology; Modeling; Mothers; National Institute of Child Health and Human Development; Outcome; Peruvian; Policies; Post-Traumatic Stress Disorders; Pregnancy; Pregnant Women; Problem behavior; Psychopathology; Public Health; Recording of previous events; Regulation; Reporting; Research; Research Design; Risk; Role; Salivary; Sample Size; Sampling; Shapes; Skin; Stress; System; Testing; Time; Trauma; Violence; Woman; Work; base; behavioral health; behavioral outcome; biobehavior; biological systems; caregiving; cohort; design; early childhood; experience; externalizing behavior; follow-up; generalized anxiety; high risk; intergenerational; intimate partner violence; maltreated children; maternal caregiving; modifiable risk; offspring; postnatal; prepregnancy; preventive intervention; prospective; protective effect; protective factors; recruit; theories

PROJECT SUMMARY Background: This study seeks to better understand maternal trauma history as a driver of behavior health problems in 4-year-old children. We will examine the impact of maternal trauma across four time periods 1) maternal experience of pre-pregnancy abuse in childhood (when mothers < 18 years), 2) maternal experience of pre-pregnancy of abuse in adulthood, 3) maternal experience of abuse during pregnancy, and 4) maternal report of postnatal abuse (after childbirth to time of assessment) on their children’s behavioral problems (internalizing and externalizing behaviors). Using a lifecourse theory approach within an intergenerational context, we will test three models to determine whether the effect of maternal trauma 1) depends on the timing of exposure (Sensitive Period model); or 2) is strongest when it is most proximal to the child outcome examined (Recency model); or 3) increases with the number of exposures (Accumulation model). A primary study aim is to investigate how “experience gets under the skin” by examining associations between maternal trauma history with children’s salivary DNA methylation (DNAm) profiles. Finally, we will test whether the effects of maternal trauma history on child health outcomes are mediated by children’s salivary DNAm profiles and maternal caregiving sensitivity. Study Design: Building on an existing prospective longitudinal cohort of Peruvian women, recruited in the first trimester of pregnancy, established as part of a prior NICHD-funded grant (n = 4,472 live births), the study has well-characterized data on maternal trauma history, maternal lifetime psychopathology, and extensive data on birth outcomes. This sample has a high prevalence of childhood maltreatment, intimate partner violence, and other traumas (88% report at least one trauma and 30% report 3 or more traumas), and psychopathology (e.g., 33% PTSD, 26% depression, and 33% generalized anxiety). We will collect follow-up data on a subset of mother-child dyads (n=1,700). Implications: By examining modifiable risk (maternal trauma history) and protective factors (maternal caregiving sensitivity), particularly in sensitive periods of development, and by determining whether and how these factors impact biological systems, this study can inform future research and interventions to address the significant intergenerational public health burden of trauma.

项目概要 背景：本研究旨在更好地了解孕产妇创伤史作为行为健康的驱动因素 我们将研究四个时期的产妇创伤的影响 1) 母亲在童年时期遭受孕前虐待的经历（当母亲 < 18 岁时），2) 母亲经历 怀孕前成年期受虐待的情况，3) 母亲在怀孕期间受虐待的经历，以及 4) 母亲受虐待的经历 关于孩子行为问题的产后虐待报告（分娩后至评估时） （内化和外化行为）。 在上下文中，我们将测试三个模型来确定产妇创伤的影响是否取决于时间 1) 暴露程度（敏感期模型）；或 2) 最接近儿童结果时最强 检查（新近度模型）；或 3) 随着暴露次数的增加（累积模型）。 研究目的是通过检查母亲与母亲之间的关联来调查“经验如何深入皮肤” 最后，我们将测试是否有创伤史与儿童唾液 DNA 甲基化 (DNAm) 谱。 产妇创伤史对儿童健康结果的影响是由儿童唾液 DNAm 谱介导的 和孕产妇护理敏感性研究设计：建立在现有的前瞻性纵向队列的基础上。 秘鲁妇女在怀孕前三个月招募，作为先前 NICHD 资助的项目的一部分而建立 补助金（n = 4,472 例活产），该研究拥有关于产妇创伤史、产妇寿命的详细数据 精神病理学和有关出生结果的大量数据该样本在儿童时期的患病率很高。 虐待、亲密伴侣暴力和其他创伤（88% 报告至少一次创伤，30% 报告 3 次） 或更多创伤）和精神病理学（例如 33% 创伤后应激障碍（PTSD）、26% 抑郁症和 33% 广泛性焦虑症）。 将收集母子二人子集 (n=1,700) 的后续数据。 含义：通过检查可修改性。 风险（产妇创伤史）和保护因素（产妇护理敏感性），尤其是敏感人群 发育时期，并通过确定这些因素是否以及如何影响生物系统， 研究可以为未来的研究和干预措施提供信息，以解决重大的代际公共卫生问题 创伤的负担。