2022 Fibroblast Growth Factors in Development and Disease GRC and GRS

2022 发育和疾病中的成纤维细胞生长因子 GRC 和 GRS

• 批准号: 10462966
• 负责人: Amy E Merrill
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462966
• 关键词: Address; Adult; Affect; Aging; Area; Attention; Autophagocytosis; Biological Process; Biology; COVID-19 pandemic; Cancer Biology; Cell Communication; Cells; Collaborations; Complex; Congenital Abnormality; Congenital Disorders; Data; Development; Diabetes Mellitus; Discipline; Disease; Embryonic Development; Endocrine; Ensure; Ethnic Origin; Event; Faculty; Feedback; Female; Fibroblast Growth Factor; Fibroblast Growth Factor Receptors; Future Generations; Gender; Generations; Geographic Locations; Geography; Germ Layers; Goals; Growth Factor Interaction; Health; Homeostasis; Hour; Human; Industry; Inflammatory; International; Italy; Knowledge; Ligands; Malignant Neoplasms; Mentors; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Multiple Sclerosis; Musculoskeletal System; Mutation; Natural regeneration; Nervous system structure; Organogenesis; Participant; Pathway interactions; Pharmacology; Physiological; Postdoctoral Fellow; Research; Research Personnel; Role; Science; Scientist; Signal Pathway; Signal Transduction; Skeleton; Syndrome; System; Technology; Therapeutic; Tissues; Translations; Travel; Underrepresented Minority; Visual; Woman; autocrine; base; craniofacial complex; graduate student; human disease; inhibitor; innovation; innovative technologies; inorganic phosphate; interest; meetings; member; multidisciplinary; nervous system disorder; novel; novel strategies; optogenetics; paracrine; phosphoproteomics; posters; programs; protein complex; receptor; repaired; senescence; sensory system; stem cells; structural biology; success; symposium; therapeutic target; tissue repair; tool

PROJECT SUMMARY Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) regulate almost all aspects of normal embryonic development, and key homeostatic, metabolic and repair mechanism in select adult tissues. Accordingly, defective FGF signaling results in a wide range of diseases including congenital birth defects, neurological disorders, metabolic diseases, inflammatory syndromes, and cancer. The field of FGF signaling, therefore, unites diverse biomedical disciplines that significantly impact human health. The overall goal of this proposal is to galvanize multidisciplinary interactions between academic scientists, clinicians, and industry leaders with a common interest in FGF biology for the benefit of human health. This goal will be achieved by gathering the top FGF-biology researchers in Il Ciocco, Italy between April 30th to May 6th, 2022, at the 8th Gordon Research Conference (GRC) on FGFs in Development and Disease 2022 conference entitled “FGF Signaling: Understanding Function and Devising Therapeutic Tools”. Prior to this GRC, an associated two-day Gordon Research Seminar (GRS), entitled “Biology, Technology and Translation in FGF Research”, organized by graduate students and postdoctoral fellows will ensure the mentoring of a new generation of FGF researchers. More specifically, the goal of this proposal will be realized through the following Specific Aims: (1) showcase new innovations that impact our mechanistic understanding of FGF-related diseases and their therapeutic advancement by featuring presentations from established leaders and new innovators; (2) encourage scientific discussions and new collaborations among trainees, scientists, and clinicians through extended poster sessions and networking opportunities; and (3) grow our existing network and capacity for future generations of FGF researchers by providing travel support and scientific feedback for trainees and junior faculty members. This GRC, postponed from its 2020 date due to the Covid19 pandemic, provides an international forum for researchers and trainees to share unique perspectives on the diverse biological functions of FGF signaling and forges new collaborations amongst these scientists. New and emerging topics such as autophagy, diabetes, multiple sclerosis and FGF's interaction with other signaling pathways will be covered. To maximize the success of the 2022 meeting, the program places particular importance on balanced speaker and attendee representation from diverse geographical locations, gender and ethnicity. Moreover, a `Power Hour' is dedicated to discussing current obstacles to, and novel approaches for, promoting wider participation of women in science.

项目概要 成纤维细胞生长因子 (FGF) 及其受体 (FGFR) 调节正常胚胎的几乎所有方面 相应地，选定成人组织的发育、关键稳态、代谢和修复机制。 FGF 信号传导缺陷会导致多种疾病，包括先天性出生缺陷、神经系统疾病 因此，FGF 信号传导领域涉及疾病、代谢疾病、炎症综合征和癌症。 该提案的总体目标是对人类健康产生重大影响的不同生物医学学科。 激发学术科学家、牧师和行业领袖之间的多学科互动 对 FGF 生物学造福人类健康的共同兴趣将通过聚集顶尖人才来实现。 FGF-生物学研究人员于 2022 年 4 月 30 日至 5 月 6 日在意大利 Il Ciocco 举行的第 8 届 Gordon Research 会议上 2022 年 FGF 在发育和疾病中的会议 (GRC) 会议题为“FGF 信号传导： 在此 GRC 之前，我们将举办为期两天的相关戈登会议。 研究研讨会（GRS），题为“FGF 研究中的生物学、技术和翻译”，组织者 研究生和博士后研究员将确保对新一代 FGF 研究人员的指导。 更具体地说，本提案的目标将通过以下具体目标来实现：（1）展示新产品 影响我们对 FGF 相关疾病及其治疗机制的理解的创新 通过知名领导者和新创新者的演讲来推动进步；(2) 鼓励科学； 通过延长海报会议，学员、科学家和忠诚者之间进行讨论和新的合作 和网络机会；(3) 为未来几代 FGF 发展我们现有的网络和能力 研究人员为实习生和初级教员提供旅行支持和科学反馈。 GRC 因 Covid19 大流行而从 2020 年推迟，为以下领域提供了一个国际论坛： 研究人员和学员分享关于 FGF 信号传导和多种生物学功能的独特观点 在这些科学家之间建立新的合作，例如自噬、糖尿病、 将涵盖多发性硬化症和 FGF 与其他信号通路的相互作用，以最大限度地取得成功。 在 2022 年会议中，该计划特别重视演讲者和与会者代表性的平衡 此外，“Power Hour”致力于讨论来自不同地理位置、性别和种族的人。 促进妇女更广泛参与科学的当前障碍和新方法。