Neural Network Dynamics Over the Course of Aversive Conditioning: The Influence of Visuocortical and Attentional Network Activity in Predicting Extinction Learning

厌恶条件作用过程中的神经网络动力学：视觉皮层和注意网络活动对预测灭绝学习的影响

• 批准号: 10463102
• 负责人: Richard Tyler Ward
• 金额: $ 6.68万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463102
• 关键词: Affect; Amygdaloid structure; Anxiety; Anxiety Disorders; Attention; Behavior; Behavioral; Brain; Clinical; Clinical Treatment; Clinical assessments; Communication; Complement; Complex; Computer Models; Cues; Data; Diagnostic; Electroencephalography; Electrophysiology (science); Etiology; Extinction (Psychology); Feedback; Fellowship; Female; Fright; Functional Magnetic Resonance Imaging; Goals; Grant; Impairment; Individual; Individual Differences; Intervention; Knowledge; Laboratories; Learning; Literature; Magnetic Resonance; Measures; Mental Health; Modeling; National Institute of Mental Health; Neuraxis; Outcome; Participant; Perception; Phenotype; Physiological; Procedures; Process; Psychophysics; Regimen; Research; Research Domain Criteria; Research Training; Resistance; Role; Sex Differences; Shapes; Structure; Techniques; Testing; Theoretical model; Time; Training; Visual; Visual Perception; Visual attention; Woman; Work; advanced analytics; anxiety treatment; attentional bias; aversive conditioning; biological sex; conditioned fear; conditioning; experience; hemodynamics; improved; learning extinction; neural network; neuroimaging; neuromechanism; neurophysiology; neuroregulation; novel; potential biomarker; relating to nervous system; response; sex; skills; tool; trait; treatment of anxiety disorders

PROJECT SUMMARY/ABSTRACT Visual cues predicting aversive outcomes facilitate low-level visual perception—often referred to as attentional threat biases—and heighten defensive engagement at the behavioral, autonomic, and central nervous system levels. However, as aversive conditioning proceeds over time, psychophysics and neuroimaging work has found threat biases accompanied by reduced, instead of heightened, activity of the brain's defensive network. Additional literature indicates that aversive conditioning is facilitated in females and individuals with greater dispositional anxiety, implicating a critical role of biological sex and individual differences in trait-like anxiety phenotypes. How these differences affect the acquisition and extinction of attentional threat biases is currently unknown. Such knowledge is critical to identifying novel neural etiological and intervention targets for clinical tools. The present training grant aims to establish the neural dynamics during visual threat bias acquisition and extinction. Specifically, we test the overarching hypothesis that temporally extended aversive conditioning increasingly relies on biased perception and attention, and less on defensive brain circuits including the amygdala. This work will contribute to NIMH strategic priorities by defining the underlying neural mechanisms contributing to complex behaviors. Thus, the proposed project aims to first (1) identify progressive changes in visual, attentional, and limbic neural networks contributing to the representation of threat versus safe-related visual cues over the course of acquisition by measuring trial-by-trial electrophysiological and hemodynamic activity. Second, (2) determine the value of individual differences in visual and attentional frontoparietal network changes during threat cue acquisition for predicting extinction and extinction recall. Third, (3) examine the extent to which individual differences in biological sex and dispositional anxiety influence changes in cortical representations of threat cues during acquisition and subsequent extinction. Participants will engage in a 2-day aversive conditioning regimen in which they undergo differential aversive conditioning followed by an extinction paradigm, and return on day 2 for a reinstatement test. Simultaneous electroencephalography (EEG) and functional magnetic resonance (fMRI) imaging during these tasks will enable the identification of functional brain alterations, fulfilling the aims of the proposed research. Pursuing these aims will aid in current efforts in improving diagnostic assessment and treatment for anxiety disorders. The training goals of this fellowship will develop the applicant's knowledge and research skills regarding theoretical components related to differential aversive conditioning, EEG-fMRI acquisition, and advanced neuroimaging analytical techniques. This project is the first to examine cortical network changes over the course of aversive conditioning, the influence these dynamics have on extinction, and how individual differences moderate these effects.

项目摘要/摘要 视觉提示预测厌恶结果喜欢的低级视觉感知 - 通常称为 注意威胁的偏见 - 并在行为，自主和中心提高防御性参与 神经系统水平。但是，随着时间的流逝，心理物理学和神经影像随着厌恶的调节 工作发现威胁偏见是通过减少而不是增强大脑防御的活动来实现的 网络。其他文献表明，在女性和患者的个人中准备厌恶条件 更大的性格动画暗示着生物学性别和个体差异的关键作用 焦虑表型。这些差异如何影响注意力威胁偏见的获取和扩展是 目前未知。这种知识对于确定新的神经病因和干预目标至关重要 临床工具。目前的培训补助金旨在在视觉威胁偏见获取期间建立神经动态 和扩展。特别是，我们测试了暂时扩展厌恶条件的总体假设 越来越依赖于偏见的感知和注意力，而少于防御性的大脑回路 杏仁核。这项工作将通过定义潜在的神经机制来促进NIMH的战略重点 促进复杂的行为。拟议的项目旨在首先（1）确定 视觉，注意力和边缘神经网络有助于威胁与安全有关 通过测量逐一试验电生理和血液动力学，视觉提示在获取过程中 活动。第二，（2）确定视觉和注意额叶网络中个体差异的价值 威胁提示收购期间的变化，以预测扩展和扩展召回。第三，（3）检查程度 生物性别和处置焦虑的个体差异会影响皮质的变化 在获取和随后的扩展期间的威胁提示表示。参与者将参加2天 厌恶条件方案，他们经历了差异性厌恶条件，然后进行延长 范式，并在第2天返回进行恢复测试。同时脑电图（EEG）和 在这些任务期间的功能磁共振（fMRI）成像将使功能性大脑识别 改变，实现拟议研究的目的。追求这些目标将有助于当前的努力改善 焦虑症的诊断评估和治疗。该奖学金的培训目标将发展 申请人关于与差异厌恶有关的理论组成部分的知识和研究技能 调理，EEG-FMRI获取和晚期神经影像学分析技术。这个项目是第一个 为了在厌恶条件的过程中检查皮质网络的变化，这些动态的影响 具有扩展以及个体差异如何缓解这些影响。

项目成果

State anxiety reduces working memory capacity but does not impact filtering cost for neutral distracters.

• DOI: 10.1111/psyp.13625
• 发表时间: 2020-10
• 期刊: PSYCHOPHYSIOLOGY
• 影响因子: 3.7
• 作者: Ward, Richard T.;Lotfi, Salahadin;Sallmann, Hannah;Lee, Han-Joo;Larson, Christine L.
• 通讯作者: Larson, Christine L.

Working Memory Performance for Differentially Conditioned Stimuli.

• DOI: 10.3389/fpsyg.2021.811233
• 发表时间: 2021
• 期刊: Frontiers in psychology
• 影响因子: 3.8
• 作者: Ward RT;Lotfi S;Stout DM;Mattson S;Lee HJ;Larson CL
• 通讯作者: Larson CL

The Relationship Between Self-Reported Misophonia Symptoms and Auditory Aversive Generalization Leaning: A Preliminary Report.

• DOI: 10.3389/fnins.2022.899476
• 发表时间: 2022
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Ward, Richard T.;Gilbert, Faith E.;Pouliot, Jourdan;Chiasson, Payton;McIlvanie, Skylar;Traiser, Caitlin;Riels, Kierstin;Mears, Ryan;Keil, Andreas
• 通讯作者: Keil, Andreas

Reward-related distracters and working memory filtering.

与奖励相关的干扰因素和工作记忆过滤。

• DOI: 10.1111/psyp.13402
• 发表时间: 2019
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Ward,RichardT;Miskovich,TaraA;Stout,DanielM;Bennett,KennethP;Lotfi,Salahadin;Larson,ChristineL
• 通讯作者: Larson,ChristineL

Neutral and threatening distracter word stimuli are unnecessarily stored in working memory but do not differ in their degree of working memory storage.

• DOI: 10.1016/j.biopsycho.2021.108091
• 发表时间: 2021-05
• 期刊: BIOLOGICAL PSYCHOLOGY
• 影响因子: 2.6
• 作者: Ward, Richard T.;Lotfi, Salahadin;Stout, Daniel M.;Mattson, Sofia;Lee, Han-Joo;Larson, Christine L.
• 通讯作者: Larson, Christine L.