Spirulina oral supplement for enhancing host resilience to virus infection

螺旋藻口服补充剂可增强宿主对病毒感染的抵抗力

• 批准号: 10447026
• 负责人: Ikhlas Ahmad Khan
• 金额: $ 118.76万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10447026
• 关键词: Address; Advisory Committees; Animal Model; Antiviral Therapy; Asthma; Biological Assay; Biological Markers; Botanical dietary supplements; Botanicals; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chemicals; Clinical Immunology; Clinical Research; Clinical Trials; Clinical trial protocol document; Collaborations; Communication; Data; Doctor of Philosophy; Dose; Drug Delivery Systems; Ensure; Evaluation; Formulation; Future; Hospitalization; Host resistance; Human; Human Subject Research; Hypersensitivity; Immune; Immune response; Immunology; In Vitro; Influenza; Intervention Studies; Knowledge; Learning; Legal patent; Lipoproteins; Liquid substance; Maintenance; Medical center; Medicine; Mississippi; Modeling; Modernization; Molecular; Mus; Natural Products; Outcome Measure; Pathogenicity; Patients; Persons; Pharmacodynamics; Pharmacy (field); Population; Postdoctoral Fellow; Powder dose form; Property; Prophylactic treatment; Recovery; Regimen; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Allocation; Scientist; Seasons; Spirulina preparation; Standardization; Structure; Supplementation; Therapeutic; Time; Universities; Viral Respiratory Tract Infection; Virus Diseases; Work; base; burden of illness; career development; design; efficacy clinical trial; efficacy study; feeding; flu; graduate student; human disease; human model; immune health; improved; infection risk; influenza infection; influenza virus vaccine; meetings; member; mid-career faculty; multidisciplinary; oral supplementation; prevent; professor; programs; resilience; seasonal influenza; socioeconomics; synergism; training opportunity; web site; Address; Advisory Committees; Animal Model; Antiviral Therapy; Asthma; Biological Assay; Biological Markers; Botanical dietary supplements; Botanicals; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chemicals; Clinical Immunology; Clinical Research; Clinical Trials; Clinical trial protocol document; Collaborations; Communication; Data; Doctor of Philosophy; Dose; Drug Delivery Systems; Ensure; Evaluation; Formulation; Future; Hospitalization; Host resistance; Human; Human Subject Research; Hypersensitivity; Immune; Immune response; Immunology; In Vitro; Influenza; Intervention Studies; Knowledge; Learning; Legal patent; Lipoproteins; Liquid substance; Maintenance; Medical center; Medicine; Mississippi; Modeling; Modernization; Molecular; Mus; Natural Products; Outcome Measure; Pathogenicity; Patients; Persons; Pharmacodynamics; Pharmacy (field); Population; Postdoctoral Fellow; Powder dose form; Property; Prophylactic treatment; Recovery; Regimen; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Allocation; Scientist; Seasons; Spirulina preparation; Standardization; Structure; Supplementation; Therapeutic; Time; Universities; Viral Respiratory Tract Infection; Virus Diseases; Work; base; burden of illness; career development; design; efficacy clinical trial; efficacy study; feeding; flu; graduate student; human disease; human model; immune health; improved; infection risk; influenza infection; influenza virus vaccine; meetings; member; mid-career faculty; multidisciplinary; oral supplementation; prevent; professor; programs; resilience; seasonal influenza; socioeconomics; synergism; training opportunity; web site

OVERALL: ABSTRACT/SUMMARY The University of Mississippi (UM) Botanical Dietary Supplements Research Center (BDSRC) is focused on filling in knowledge gaps related to the potential for the Spirulina-based product, ImmulinaTM, to promote resilience against and/or recovery from influenza and, by extension, other respiratory viral infections. ImmulinaTM is a patented bioassay-standardized extract that concentrates the active immunostimulatory compounds in Spirulina, i.e., Braun-type lipoproteins. Researchers affiliated with the UM BDSRC have generated evidence that supports reproducible and mechanistically plausible effects of ImmulinaTM for enhancing host responses that may promote resilience against respiratory viral infections such as influenza. Last year in the U.S. alone, influenza resulted in 959,000 patient hospitalizations and 79,400 deaths. Under the direction of Ikhlas Khan, PhD and Nirmal Pugh, PhD, the UM BDSRC includes a well- established collaborative team of multi-disciplinary investigators with expertise in natural products, animal models of human diseases, pharmaceutics, immunology, and human subject research. The UM BDSRC will be composed of an Administration Core, a Botanical Core, and two research projects: (1) Unraveling Immune Enhancement by ImmulinaTM, and (2) Evaluation of ImmulinaTM Oral Supplement for Host Resistance to Influenza Virus Infection. The overall specific aims are to: (1) maximize coordination of effort, communication among researchers, training opportunities for career development, and dissemination of knowledge through a well-managed and effective Administrative Core; (2) ensure product integrity of the ImmulinaTM extract through a combination of bioassay- and chemical-based approaches for standardization within the Botanical Core; (3) determine the molecular mechanism of immune enhancement of ImmulinaTM and optimal formulation and dosing in Project 1’s mouse study that can be utilized by the UM BDSRC’s other studies; and (4) using both a mouse and subsequently a biomarker-based human model, establish the impact of ImmulinaTM supplementation on increasing host resilience against the pathogenic effects of influenza virus infection with Project 2. The Administrative Core, guided by an External Advisory Committee and an Internal Steering Committee, will oversee all aspects of the UM BDSRC, including progress towards meeting its milestones, efficient allocation of resources, collaborations with researchers outside the UM BDSRC, oversight of its graduate students and post-doctoral fellows, and maintenance of its website. Members of the Botanical Core will work closely with researchers from the UM BDSRC to provide sufficient quantities of standardized ImmulinaTM extract and to collaborate with other units of CARBON on future efficacy studies of ImmulinaTM. The results from Projects 1 and 2 will help establish the optimal regimen for future clinical efficacy trials.

总体：摘要/摘要 密西西比大学（UM）植物饮食补充剂研究中心（BDSRC）集中于 填补与基于螺旋藻的产品Immulinatm相关的知识差距，以促进 反对和/或从影响力和/或恢复的弹性，并扩展了其他呼吸道病毒感染。 Immulinatm是一种专利的生物测定标准提取物，浓缩活性免疫刺激性 螺旋藻中的化合物，即Braun型脂蛋白。研究人员有UM BDSRC有 生成的证据支持immulinatm的可再现和机械上合理的作用 增强宿主反应，可能会促进针对呼吸道病毒感染（例如影响力）的弹性。 仅去年在美国，Intralencena就会导致959,000例患者住院和79,400人死亡。 在Ikhlas Khan博士和Nirmal Pugh博士的指导下，UM BDSRC包括一个很好的 建立的多学科研究人员的合作团队具有天然产品专业知识，动物 人类疾病，药物，免疫学和人类学科研究的模型。 UM BDSRC将是 由管理核心，植物核心和两个研究项目组成：（1）揭开免疫力 通过免疫来增强，（2）评估宿主抗性的疫苗口服补充剂 流感病毒感染。 总体具体目的是：（1）最大的努力协调，研究人员之间的沟通， 培训职业发展的机会，并通过管理良好的和 有效的行政核心； （2）通过组合确保iMpulinatm提取物的产品完整性 基于生物测定和化学化学方法的植物核心中的标准化方法； （3）确定 免疫增强免疫和最佳配方的免疫增强的分子机制 UM BDSRC的其他研究可以利用1的小鼠研究； （4）同时使用鼠标和 随后，基于生物标志物的人类模型，建立补充剂对 宿主的弹性提高了对影响感染影响2的流感病毒感染的致病作用。 行政核心，由外部咨询委员会和内部指导委员会指导， 将监督UM BDSRC的各个方面，包括朝着其里程碑，高效的进步 资源分配，与UM BDSRC以外的研究人员的合作，对其研究生的监督 学生和博士后研究员以及其网站的维护。植物核心的成员将起作用 与UM BDSRC的研究人员紧密相关，以提供足够数量的标准化疫苗 提取并与其他碳单位合作，以对疫苗的未来效率研究进行合作。结果 从项目1和2中，将有助于建立未来临床效率试验的最佳方案。