Combined Experimental and Analytical Study of the Effects of Zone V Extensor Tendon Injuries on Hand Function

V区伸肌腱损伤对手功能影响的实验与分析相结合的研究

• 批准号: 10440853
• 负责人: Muturi G Muriuki
• 金额: $ 22.61万
• 依托单位: CHICAGO ASSN FOR RESEARCH & EDUC IN SCI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10440853
• 关键词: Affect; Aftercare; Algorithms; Amputees; Analysis of Variance; Anatomy; Biomechanics; Cadaver; Catalogs; Clinical Treatment; Communication; Data; Development; Extensor; Fingers; Flexor; General Population; Goals; Grooming; Hand; Hand Injuries; Hand Strength; Hand functions; Hygiene; Incidence; Injury; Interruption; Laceration; Measures; Modeling; Motion; Occupational; Operative Surgical Procedures; Outcome; Outcome Assessment; Output; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Pattern; Persons; Play; Procedures; Quality of life; Reporting; Research; Role; Rotation; Running; Severities; Skin; Specimen; Surface; System; Tendon Injuries; Tendon structure; Time; Trauma; Treatment outcome; Variant; Work; anterior cruciate ligament injury; disability; experimental group; experimental study; grasp; hand dysfunction; improved; mathematical model; model development; outcome prediction; sex; skeletal tissue; soft tissue; tool; treatment optimization

Extensor tendon injuries of the hand are common and potentially debilitating. The long-term objective of this research is to improve patient outcomes following extensor tendon injury. The first step towards this objective is to determine the effect of extensor tendon injury on patient function. Additional steps can then be taken to improve treatment and outcomes once the underlying causes of poor patient outcomes are known. The first step is the focus of this proposed work. Cadaveric experiments and mathematical modeling will be used to increase our understanding of the effect of extensor tendon injuries on hand function, and to improve treatments for extensor tendon injuries. In the cadaveric experiments the extensor tendons will be loaded to generate finger motion. Tendon excursion, tendon load, grip and finger rotation will be measured during these experiments. There will be two experimental groups with different patterns of extensor injury. Data collected from the first experimental group will be used to create mathematical models relating extensor tendon injury to finger function. The mathematical models will take simulated injury as an input and output finger motion and grip strength. An optimization procedure will be used to generate the models. Given the extensor tendon injury configuration in group one, the optimization will adjust the mathematical model parameters to minimize the difference between model output and group one data. These optimized mathematical models will then be given group two injury configurations as a system input. The accuracy of the mathematical models will be determined by comparing the model’s outputs to data collected from the second experimental group. The effect of extensor tendon injury on finger function will be determined using repeated measures analysis of variance. Accuracy of the mathematical models will be quantified using a similarity metric comparing the second group’s experimental data to the output of the mathematical models using group two’s set of simulated extensor injury.

手的延伸肌腱损伤是常见的，并且可能使人衰弱。长期目标的 这项研究是为了改善肌腱损伤后的患者预后。迈向这一迈出的第一步 目的是确定外肌腱损伤对患者功能的影响。然后可以是其他步骤 一旦知道了患者不良结局的根本原因，就可以改善治疗和结果。这 第一步是这项拟议工作的重点。 尸体实验和数学建模将用于增加我们对效果的理解 手动功能上肌腱损伤的延伸，并改善肌腱损伤的治疗方法。 在尸体实验中，将加载外部肌腱以产生手指运动。肌腱 在这些实验期间，将测量偏移，肌腱载荷，抓地力和手指旋转。会有两个 具有不同外部伤害模式的实验组。从第一个实验收集的数据 组将用于创建有关手指功能的外部肌腱损伤的数学模型。这 数学模型将模拟伤害作为输入和输出手指运动和握力强度。一个 优化过程将用于生成模型。考虑到外部肌腱损伤配置 第一组，优化将调整数学模型参数，以最大程度地减少 模型输出和组一个数据。 然后，将将这些优化的数学模型作为系统输入进行组两个伤害配置。 数学模型的准确性将通过将模型的输出与数据进行比较来确定 从第二实验组收集。 外部肌腱损伤对手指功能的影响将使用重复测量分析确定 差异。数学模型的准确性将使用相似性度量进行量化 第二组的实验数据使用第二组的模拟集对数学模型的输出 伸肌受伤。