Combined Experimental and Analytical Study of the Effects of Zone V Extensor Tendon Injuries on Hand Function

V区伸肌腱损伤对手功能影响的实验与分析相结合的研究

• 批准号: 10440853
• 负责人: Muturi G Muriuki
• 金额: $ 22.61万
• 依托单位: CHICAGO ASSN FOR RESEARCH & EDUC IN SCI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10440853
• 关键词: Affect; Aftercare; Algorithms; Amputees; Analysis of Variance; Anatomy; Biomechanics; Cadaver; Catalogs; Clinical Treatment; Communication; Data; Development; Extensor; Fingers; Flexor; General Population; Goals; Grooming; Hand; Hand Injuries; Hand Strength; Hand functions; Hygiene; Incidence; Injury; Interruption; Laceration; Measures; Modeling; Motion; Occupational; Operative Surgical Procedures; Outcome; Outcome Assessment; Output; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Pattern; Persons; Play; Procedures; Quality of life; Reporting; Research; Role; Rotation; Running; Severities; Skin; Specimen; Surface; System; Tendon Injuries; Tendon structure; Time; Trauma; Treatment outcome; Variant; Work; anterior cruciate ligament injury; disability; experimental group; experimental study; grasp; hand dysfunction; improved; mathematical model; model development; outcome prediction; sex; skeletal tissue; soft tissue; tool; treatment optimization

Extensor tendon injuries of the hand are common and potentially debilitating. The long-term objective of this research is to improve patient outcomes following extensor tendon injury. The first step towards this objective is to determine the effect of extensor tendon injury on patient function. Additional steps can then be taken to improve treatment and outcomes once the underlying causes of poor patient outcomes are known. The first step is the focus of this proposed work. Cadaveric experiments and mathematical modeling will be used to increase our understanding of the effect of extensor tendon injuries on hand function, and to improve treatments for extensor tendon injuries. In the cadaveric experiments the extensor tendons will be loaded to generate finger motion. Tendon excursion, tendon load, grip and finger rotation will be measured during these experiments. There will be two experimental groups with different patterns of extensor injury. Data collected from the first experimental group will be used to create mathematical models relating extensor tendon injury to finger function. The mathematical models will take simulated injury as an input and output finger motion and grip strength. An optimization procedure will be used to generate the models. Given the extensor tendon injury configuration in group one, the optimization will adjust the mathematical model parameters to minimize the difference between model output and group one data. These optimized mathematical models will then be given group two injury configurations as a system input. The accuracy of the mathematical models will be determined by comparing the model’s outputs to data collected from the second experimental group. The effect of extensor tendon injury on finger function will be determined using repeated measures analysis of variance. Accuracy of the mathematical models will be quantified using a similarity metric comparing the second group’s experimental data to the output of the mathematical models using group two’s set of simulated extensor injury.

手部伸肌腱损伤很常见，并且可能使人衰弱。 这项研究是为了改善伸肌腱损伤后的患者治疗效果，这是实现这一目标的第一步。 目的是确定伸肌腱损伤对患者功能的影响，然后可以采取其他步骤。 一旦了解患者预后不良的根本原因，就可以采取措施改善治疗和结果。 第一步是这项拟议工作的重点。 尸体实验和数学模型将用于增加我们对效应的理解 伸肌腱损伤对手部功能的影响，并改进伸肌腱损伤的治疗。 在尸体实验中，伸肌腱将被加载以产生手指运动。 在这些实验中将测量偏移、肌腱负载、握力和手指旋转。 具有不同伸肌损伤模式的实验组从第一个实验中收集数据。 小组将用于创建将伸肌腱损伤与手指功能相关的数学模型。 数学模型将模拟伤害作为输入，输出手指运动和握力。 考虑到伸肌腱损伤配置，将使用优化程序来生成模型。 第一组，优化将调整数学模型参数以最小化之间的差异 模型输出和第一组数据。 然后，这些优化的数学模型将被给予第二组损伤配置作为系统输入。 数学模型的准确性将通过将模型的输出与数据进行比较来确定 收集自第二个实验组。 将通过重复测量分析确定伸肌腱损伤对手指功能的影响 数学模型的准确性将使用比较的相似性度量来量化。 使用第二组的模拟数据将第二组的实验数据转换为数学模型的输出 伸肌损伤。