One-Health Approach to Study Human Fasciola hepatica Transmission and Inform Strategic Control

研究人类肝片形吸虫传播并为战略控制提供信息的单一健康方法

基本信息

批准号：
10435287
负责人：
MIGUEL MAURICIO CABADA
金额：
$ 52.69万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-22 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10435287
关键词：
Address Affect Africa Aftercare Agriculture Anemia Animals Antigens Area Automobile Driving Biological Factors Cells Child Chronic Collaborations Communicable Diseases Communities Complex Country DNA Data Developed Countries Developing Countries Development Diagnosis Diagnostic Diagnostic Procedure Diagnostic tests Disease Drug resistance Economics Effectiveness Environment Environmental Risk Factor Epidemiologic Factors Epidemiology Far East Fasciola Fasciola hepatica Fascioliasis Fostering Geographic Information Systems Goals Growth Habitats Health Helminths Hematopoietic Hepatica Human Human Resources Image Immune Immunologic Memory Immunology In Vitro Incidence Infection Inflammatory Response Innate Immune Response Intervention Liver diseases Livestock Malnutrition Methods Middle East Modeling Molecular Mus Parasite Control Parasites Parasitology Peru Peruvian Pharmaceutical Preparations Polymerase Poverty Predisposition Prevalence Production Prospective cohort Public Health Reporting Research Research Personnel Resolution Resource-limited setting Resources Risk Risk Factors Ruminants Rural Community Sampling Studies School-Age Population Site Snails South America Southeastern Asia Specimen Statistical Data Interpretation Statistical Models T cell response Testing Time Training Treatment Effectiveness Treatment Efficacy Treatment Failure Trematode Infections Tropical Medicine Ursidae Family Weather Zoonoses adaptive immune response base burden of illness chemotherapy chronic infection cohort drug efficacy enzootic experience food insecurity high resolution imaging infection burden infection risk insight land use macrophage multidisciplinary neglected tropical diseases novel predicting response preventive intervention recombinase response stem surveillance strategy tool transmission process treatment response vaccine response

Address Affect Africa Aftercare Agriculture Anemia Animals Antigens Area Automobile Driving Biological Factors Cells Child Chronic Collaborations Communicable Diseases Communities Complex Country DNA Data Developed Countries Developing Countries Development Diagnosis Diagnostic Diagnostic Procedure Diagnostic tests Disease Drug resistance Economics Effectiveness Environment Environmental Risk Factor Epidemiologic Factors Epidemiology Far East Fasciola Fasciola hepatica Fascioliasis Fostering Geographic Information Systems Goals Growth Habitats Health Helminths Hematopoietic Hepatica Human Human Resources Image Immune Immunologic Memory Immunology In Vitro Incidence Infection Inflammatory Response Innate Immune Response Intervention Liver diseases Livestock Malnutrition Methods Middle East Modeling Molecular Mus Parasite Control Parasites Parasitology Peru Peruvian Pharmaceutical Preparations Polymerase Poverty Predisposition Prevalence Production Prospective cohort Public Health Reporting Research Research Personnel Resolution Resource-limited setting Resources Risk Risk Factors Ruminants Rural Community Sampling Studies School-Age Population Site Snails South America Southeastern Asia Specimen Statistical Data Interpretation Statistical Models T cell response Testing Time Training Treatment Effectiveness Treatment Efficacy Treatment Failure Trematode Infections Tropical Medicine Ursidae Family Weather Zoonoses adaptive immune response base burden of illness chemotherapy chronic infection cohort drug efficacy enzootic experience food insecurity high resolution imaging infection burden infection risk insight land use macrophage multidisciplinary neglected tropical diseases novel predicting response preventive intervention recombinase response stem surveillance strategy tool transmission process treatment response vaccine response

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项目摘要

PROJECT SUMMARY/ABSTRACT Fascioliasis in an important zoonic infection with a worldwide distribution. It is a significant public health problem in poor rural communities in countries of South America, Middle East, Asia, and Africa. School age children bear a disproportionate burden of the diseases suffering from anemia and stunted growth. Fasciola causes substantial economic losses in livestock production in developed and developing countries. It has a complex epidemiology stemming from its capacity to infect multiple definitive hosts and more than 30 species of snails and adapt to multiple environments. Despite Fasciola’s inclusion in the WHO neglected tropical diseases list very little progress in parasite control has been achieved. Mass treatment has been the preferred control intervention in human and livestock. However, a single drug, triclabendazole, is recommended for treatment and control in humans and preferred for livestock. Concerns for decreasing efficacy of triclabendazole have been raised in endemic countries. Tools to predict fascioliasis risk and guide preventive interventions have focused on livestock. Most models have ignored human infection risk and factor associated with vulnerability such as treatment failure, poverty, and susceptibility. Out TMRC application proposes using a comprehensive One Health approach to study human transmission of Fasciola in two sites of the Peruvian highlands. Our approach will consider the spatial and temporal association of fascioliasis in snail intermediate hosts, livestock, human, and the environment. Importantly we will include studies to tackle factors that modify the risk of infection among human such as weather and land use, hinder diagnosis and surveillance such as the lack of simple diagnostic tests to use in all hosts, and the potential effects of chronic infection on treatment response and infection susceptibility. We will use agent-based modeling to identify crucial steps in transmission and potential areas of intervention that could be address simultaneous with a large impact on transmission and small impact on the environment and drug effectiveness. At the end of our TMRC we expect to gain substantial insights into human Fasciola transmission and to identify potential integrated control interventions, simple sensitive tools to diagnose and surveil infection, and immune mechanisms behind drug effectiveness and infection susceptibility.

项目摘要/摘要在全球分布的重要人造感染中筋膜病。这是一个重大的公共卫生问题在南美，中东，亚洲和非洲国家的贫困农村社区中。学龄儿童熊患有贫血和发育迟缓的疾病的伯恩（Burnen）不成比例。 fasciola会导致大量发达国家和发展中国家牲畜生产的经济损失。它具有复杂的流行病学由于其能力感染多个确定宿主和30多种蜗牛的能力并适应多个环境。尽管Fasciola将被忽视的热带疾病列入了很少的列表寄生虫控制方面的进展已取得成功。大规模治疗一直是首选的控制干预措施人和牲畜。但是，建议一种一种药物，三苯甲唑，用于治疗和控制人类，首选牲畜。人们对降低三班替唑效率的担忧已提高内在国家。预测筋膜症风险和指导预防干预措施的工具集中在牲畜上。大多数模型都忽略了人类感染的风险和与脆弱性有关的因素，例如治疗失败，贫穷和易感性。使用全面的一种健康方法提出TMRC申请建议在秘鲁高地的两个地点研究筋膜的人类传播。我们的方法将考虑蜗牛中间宿主，牲畜，人类和人类的空间和临时关联环境。重要的是，我们将包括解决改变人类感染风险的因素的研究例如天气和土地利用，阻碍诊断和监视，例如缺乏简单的诊断测试在所有宿主中使用，以及慢性感染对治疗反应和感染敏感性的潜在影响。我们将使用基于代理的建模来确定传播和潜在干预领域的关键步骤这可以同时解决，对传播的影响很大，对环境的影响很小和药物有效性。在我们的TMRC结束时，我们期望对人类fasciola获得大量见解传输并确定潜在的综合控制干预措施，简单的敏感工具以诊断和监测感染以及药物有效性和感染敏感性背后的免疫力学。