Predoctoral Training in Quantitative Cell & Molecular Biology

定量细胞博士前培训

• 批准号: 10430178
• 负责人: Juan Lucas Argueso
• 金额: $ 39.72万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430178
• 关键词: Cellular biology; Molecular Biology; Training; pre-doctoral

Project Summary/Abstract The Quantitative Cell and Molecular Biology (qCMB) Training Program will provide comprehensive and flexible training in quantitative approaches in order to facilitate transdisciplinary and collaborative research in the broad field of Cell & Molecular Biology. The Program will produce outstanding graduates with the skills to meet the computational and professional demands of modern life science research. The objectives include to produce more graduates able to apply computational approaches to solve biological problems, build and sustain an accessible curriculum to provide training in this area, encourage and support transdisciplinary collaborations, provide training and professional development opportunities to better prepare students for the workforce, and facilitate completion by fostering a supportive and inclusive environment. The qCMB program is designed to support students engaging in collaborative research projects requiring the generation and analysis of large biological datasets particularly those generated through sequencing, imaging and flow cytometry. It combines recently developed computational and quantitative coursework with a new gateway course developed for this program, and innovative approaches to encourage reproducible research. Progress will be monitored through annual reports, seminars and committee meetings. Trainees will be prepared for entry to the workforce through personalized career mentoring, along with professional skills training, mentoring from industry professionals and guided access to internship experiences. Trainees will be welcomed and supported regardless of race, gender, age, sexual orientation or disability. The program will facilitate this through peer mentoring, established events such as an Annual Picnic, and Poster Symposium. We will build a qCMB community through monthly meetings, and a summer symposium/retreat. Preceptors will be supported through required training that will hone their mentoring skills and convey strategies to ensure mentees engage in reproducible research. Existing and new collaborations between preceptors working in areas such as Biology of Single Cells, Post-Transcriptional Control, Genome Architecture & Function, and Protein Structure & Function will provide students with opportunities to engage in transdisciplinary quantitative/computational research that requires comprehension of cell and molecular biology. Preceptor mentoring plans and effectiveness will be evaluated by the qCMB leadership. Potential trainees (8-10 each year) are recruited into the existing interdisciplinary Cell & Molecular Biology PhD Program, and rotate during their first year to identify a lab/preceptor that fits their research interests and mentoring needs. At the end of the first year, three trainees entering qCMB labs will be selected for support through this award and each will be supported for two years before transitioning to the preceptor's research grant or other fellowship for stipend support. The award will support a total of 15 trainees, who will transition to positions in academia, or industry that require data analysis, collaboration and research experience.

项目摘要/摘要 定量细胞和分子生物学（QCMB）培训计划将提供全面而灵活的 定量方法的培训，以促进广泛的跨学科和协作研究 细胞和分子生物学领域。该计划将培养出杰出的毕业生，并以满足 现代生命科学研究的计算和​​专业需求。目标包括生产 更多能够采用计算方法来解决生物学问题，建立和维持的毕业生 可访问的课程以在此领域提供培训，鼓励和支持跨学科合作， 提供培训和专业发展的机会，以更好地为学生做好准备，并 通过培养支持性和包容性环境来促进完成。 QCMB计划旨在支持学生参与协作研究项目，要求 大型生物数据集的生成和分析，尤其是通过测序，成像生成的数据集 和流式细胞仪。它结合了最近开发的计算和定量课程和一个新的 为该计划开发了Gateway课程，以及鼓励可重复研究的创新方法。 将通过年度报告，研讨会和委员会会议来监控进度。学员会 准备通过个性化的职业指导进入劳动力以及专业技能 培训，行业专业人员的指导以及获得实习经验的指导机会。 无论种族，性别，年龄，性取向或残疾如何，受训者都将受到欢迎和支持。这 计划将通过同行指导，诸如年度野餐和海报等既定活动来促进这一点 座谈会。我们将通过每月会议和夏季研讨会/静修会来建立QCMB社区。 将通过所需的培训来支持主持人，以磨练他们的指导技能并传达 确保受训者从事可重复研究的策略。现有和新的合作 在单细胞生物学，转录后控制，基因组等领域工作的受体 建筑和功能以及蛋白质结构和功能将为学生提供参与的机会 跨学科定量/计算研究需要理解细胞和分子 生物学。主教指导计划和有效性将由QCMB领导层评估。 潜在的学员（每年8-10）被招募到现有的跨学科细胞和分子生物学博士 计划，并在第一年旋转，以确定适合其研究兴趣的实验室/官员 指导需求。在第一年结束时，将选出三名进入QCMB实验室的学员进行支持 通过这个奖项，每个奖项将得到两年的支持，然后过渡到主教的研究 赠款或其他奖学金奖学金。该奖项将支持15名受训人员，他们将过渡到 在学术界或需要数据分析，协作和研究经验的行业的职位。