Training Program in Investigative Rheumatology

风湿病研究培训计划

• 批准号: 10426158
• 负责人: RICHARD J BUCALA
• 金额: $ 39.12万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-07-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10426158
• 关键词: Rheumatology; Training Programs

PROJECT SUMMARY This T32 program in Investigative Rheumatology, currently in its 44th year, is dedicated to the foremost research training of biomedical scientists to prepare future leaders for the investigation of rheumatologic and immunologic diseases. The program continues with its core philosophy that advanced training in the fundamental methodologies of laboratory and translational research is essential for elucidating pathogenic mechanisms, and for devising more effective therapeutic and preventative strategies. The program will recruit the most highly qualified candidates from among clinical and post- graduate fellows with prior research achievement (MD, PhD, and MD/PhD). Training is interdisciplinary, enriched by specialized post-graduate coursework, and led by 30 faculty from the School of Medicine who are both distinguished in their respective fields of investigation and have an excellent track record of mentorship. The unique features of this program originate from: a) An emphasis on molecular mechanisms of human disease and state-of-the-art methodologies, including high-sensitivity and high-throughput profiling technologies, genomics, microbiome research, bioinformatics, and genetically-based disease modeling; b) An accomplished training faculty and existing collaborative interactions between the basic and clinical scientists; and c) A focused mission to create a scientifically-minded cadre of physician-scientists able to engage the challenges of rheumatologic diseases with incisive hypotheses and state-of-the-art experimental approaches. The program will build on existing investigative programs in autoimmunity, inflammation, and clinical immunology, and incorporate recent research initiatives. Four trainees (MD and PhD) per year are currently supported and the same number is requested in this renewal application. MD trainees typically perform clinical work in the first year of their fellowship and then enter research training under T32 support; some additionally enroll in a Masters or PhD degree-granting program. Research training is typically for 2-3 years, with subsequent training years supported by individual fellowship grants or career development awards. The inclusion in this program of both MD and PhD fellows provides a rich training experience, and fellows receive didactic and interactive instruction in biology, research methodologies, and career and ethical guidance in conducting research. This program provides trainees with a foundation in advanced research to better enable them to bridge experimental investigation with clinical information, and thus improve understanding in rheumatologic diseases. Success is measured by our accruing pool of graduates who initiate investigative careers, develop into accomplished physician- scientists, and achieve leadership positions in academic medicine.

项目摘要 该调查性风湿病学的T32计划目前已有44年，专门用于 生物医学科学家的最重要的研究培训，以准备未来的领导者调查 风湿病和免疫疾病。该计划继续其核心理念， 在实验室和转化研究的基本方法论中培训对于 阐明致病机制，并设计更有效的治疗性和预防性 策略。该计划将从临床和后招募最高资格的候选人 具有先前研究成就的研究生研究生（MD，PhD和MD/PhD）。培训是跨学科的， 由专业的研究生课程丰富，由医学院的30位教师领导 两者在各自的调查领域都有区别，并且具有出色的记录 指导。该程序的独特特征起源于：a）强调分子机制 人类疾病和最先进的方法论，包括高敏性和高通量 分析技术，基因组学，微生物组研究，生物信息学和基于遗传的疾病 造型; b）基本和基本的培训教师和现有的合作互动 临床科学家； c）专注于创建科学意识的医师科学家干部 能够通过敏锐的假设和最先进的假设参与风湿病的挑战 实验方法。该计划将基于自动免疫现有的调查计划， 炎症和临床免疫学，并纳入了最新的研究计划。四名学员（MD和 目前支持博士学位），并且在此续签申请中要求相同的数字。 MD 学员通常在奖学金的第一年进行临床工作，然后进入研究培训 在T32支持下；一些人还参加了硕士学位或博士学位授予课程。研究 培训通常为2 - 3年，随后由个人奖学金赠款支持的培训年 或职业发展奖。在此计划中，MD和PhD研究员的包含提供了丰富的 培训经验，研究员接受生物学，研究的教学和互动教学 方法论以及进行研究的职业和道德指导。该计划为受训者提供 通过高级研究的基础，使他们能够与 临床信息，从而提高对风湿病疾病的理解。成功是由 我们启动调查职业的毕业生的累积库，发展为有成就的医师 - 科学家，并在学术医学中获得领导地位。