Immunologic Basis of Resistance and Hypersensitivity

耐药性和超敏反应的免疫学基础

• 批准号: 10426170
• 负责人: Joshua A Boyce
• 金额: $ 50.87万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426170
• 关键词: Hypersensitivity; Immunologics; Resistance

Project Summary This continuation of an established training program seeks to prepare qualified M.D., Ph.D., and M.D./Ph.D. candidates for academic careers in the field of allergy and immunology. Support is again requested for seven postdoctoral trainees having either a M.D. or Ph.D. degree or both. The training program emphasizes three major areas: basic science, translational science, and clinical science. The trainees focused in basic science learn techniques and concepts of immunopharmacology, immunochemistry, and cellular and molecular immunology. Areas of emphasis include the basic biology of mast cells, lipid mediators, dendritic cells, innate lymphoid cells, and animal models of allergic disease. Trainees in translational science paths incorporate informatic approaches to analyze genetic, genomic, and unbiased sequencing or metabolomic data to understand the mechanistic basis of human allergic diseases. Such trainees may also employ bench side approaches to studies using human cells and tissues. Trainees in clinical sciences may focus on epidemiology or clinical trials. The faculty are highly accomplished investigators with extensive mentoring track records and substantial extramural grant support. The three-year research training period is designed so that each trainee learns a range of techniques and approaches, gains a broad understanding of the innate and adaptive immune host responses, and establishes a template for an early career research focus. This time frame also permits the trainee, along with his or her mentor and Mentoring Subcommittee, to plan for post-fellowship career development, with the goal of defining a path in academia that is commensurate with the trainee’s developing skills and interests. The research experience is enhanced by didactic course work, as well as workshops in grant writing, manuscript composition, and lab management. The program continues to be highly successful, with over 75% of the graduates in the past decade having full-time academic appointments, many of whom are primarily research based with independent NIH support.

项目摘要 建立培训计划的这种延续旨在准备合格的M.D.，Ph.D.和M.D./ph.d。 过敏和免疫学领域的学术职业候选人。再次要求支持七个 具有医学博士学位或博士学位的博士后学员学位或两者兼而有之。培训计划强调三个 主要领域：基础科学，转化科学和临床科学。培训专注于基础科学 学习免疫药理学，免疫化学以及细胞和分子的技术和概念 免疫学。重点领域包括肥大细胞，脂质介质，树突细胞，先天物的基本生物学 淋巴样细胞和过敏性疾病的动物模型。翻译科学路径的学员 分析遗传，基因组和无偏的测序或代谢组数据的信息性方法 了解人类过敏性疾病的机械基础。这样的受训者也可以雇用长凳 使用人类细胞和组织进行研究的方法。临床科学学员可以专注于流行病学 或临床试验。该教师是具有广泛心理记录的高度成就的调查员， 大量的壁外赠款支持。设计了三年的研究培训期，以便每个学员 了解一系列技术和方法，对先天和适应性免疫有广泛的了解 主持人的回应，并为早期职业研究重点建立模板。这个时间范围也允许 受训者，以及他或她的心理和指导小组委员会，以计划后职业生涯 开发，目的是定义学术界的道路，该路径与受训者的发展相称 技能和兴趣。教学课程工作以及讲习班都可以增强研究经验 赠款写作，手稿组成和实验室管理。该计划继续非常成功， 在过去的十年中，有超过75％的毕业生有全日制学术约会，其中许多是 基于独立NIH支持的主要研究。