Administrative Core

行政核心

• 批准号: 10428165
• 负责人: Ignacio E. Sanz
• 金额: $ 10.18万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-25 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10428165
• 关键词: Accounting; Accreditation; Alabama; American; Animals; B-Lymphocytes; Budgets; COVID-19 vaccination; Cellular biology; Certification; Clinical; Clinical Trials; Communities; Complex; Conflict of Interest; Data; Deposition; Disclosure; Disease; Enrollment; Ensure; Epigenetic Process; Expenditure; Feedback; Financial Support; Funding; Future; General Population; Goals; Grant; Guidelines; Health; Human; Human Resources; IACUC; Immunologist; Immunology; Inflammation; Information Dissemination; Infrastructure; Institutional Review Boards; International; Investigation; Joints; Laboratories; Laboratory Personnel; Leadership; Manuscripts; Monitor; Occupational activity of managing finances; Oral; Patient Recruitments; Personnel Recruitments; Plasma Cells; Policies; Process; Productivity; Progress Reports; Protocols documentation; Publications; Regulation; Reporting; Research; Research Personnel; Research Subjects; Resources; Rheumatology; Safety; Science; Structure; Students; System; Time; TimeLine; Training; United States National Institutes of Health; Universities; Update; Videoconferencing; Work; Workplace; animal care; animal safety; college; data sharing; design; experience; meetings; member; operation; patient safety; plasma cell development; programs; recruit; repository; sample collection; success; symposium; synergism; transcriptomics

ADMINISTRATIVE CORE A ABSTRACT. Coordinated leadership through a strong administrative structure is an essential component of the success of complex multiple-laboratory projects. This is particularly true for projects involving human research as there are additional recruitment, safety, and regulatory concerns that must be met. The purpose of Core A is to facilitate progress of the projects of the PPG in understanding the processes that underly plasma cell development and its dysregulation in disease. To accomplish this objective, we will continue to build and refine the infrastructure that we have been developing over the previous 5 years for the administration of this PPG. The function of Core A will continue to be to provide administrative support, organization, coordination and efficient management of this PPG with the overarching goal of ensuring the scientific productivity of all projects. Core A will be directed by Dr. Iñaki Sanz (overall P.I., and Project 4 Leader), who in addition to being a world class expert on human B cell biology, has also accumulated substantial experience in directing multi-investigator research programs over the past 20 years. He will be assisted by two recruited expert staff members; Dr. Amy Stout who has extensive experience providing administrative and financial support and overseeing multi-center projects at Emory University and Ms. Sang Le who has 15 years experience overseeing specimen collection programs and enabling large clinical trials within the Emory IRB system. Through administrative oversight and guidance, we will ensure proper and timely fiscal management and efficient use of human and financial resources. Core A will make sure that all staff and support personnel are trained and accredited for safety, Institutional Review Board, and institutional animal care and use purposes. Core A will also track study enrollment and provide a continuing review of enrollment to PIs to ensure overall patient recruitment goals and timelines are being met. The Core will continue to provide scientific coordination and interaction through structured monthly, quarterly, and yearly meetings, and will monitor project progress and assist PIs with annual progress reports. Oversight will additionally be provided by an established External Advisory Board of accomplished immunologists with extensive relevant expertise in B cell biology, tolerance, inflammation and epigenetics. Core A will facilitate interactions between PPG leadership and the External Advisory Board through planning and execution of a yearly meeting designed to provide project updates, discuss ongoing and future studies, and obtain objective feedback on the overall status of the program. The core will also ensure timely dissemination of results and data sharing though project presentation and publication targets. By streamlining and consolidating administrative task and providing strategic leadership and internal and external coordination, Core A will enable the project PIs to collaboratively produce rigorous and impactful scientific findings that increase our understanding of plasma cells and positively influence human health. 1

行政核心摘要。 通过强大的行政结构协调领导是成功的重要组成部分 复杂的多种实验室项目。对于涉及人类研究的项目，尤其如此 必须满足的其他招聘，安全和监管问题。核心A的目的是促进 PPG项目在了解血浆细胞开发下的过程和 它在疾病中的失调。为了实现这一目标，我们将继续建立和完善基础设施 在过去的5年中，我们一直在发展该PPG。核心的功能 A将继续是提供行政支持，组织，协调和有效管理 该PPG的总体目标是确保所有项目的科学生产力。 核心A将由IñakiSanz博士（总体P.I.和Project 4 Leader）指导，除了成为世界外 人类B细胞生物学的班级专家也积累了指导多注评家的丰富经验 在过去20年中的研究计划。他将得到两名招聘专家工作人员的协助；艾米博士 斯托特（Stout）拥有丰富的经验，可以提供行政和财务支持并监督多中心 Emory University和Sang Le女士的项目，他们有15年的经验监督标本收集 计划并在Emory IRB系统中进行大型临床试验。通过行政监督和 指导，我们将确保适当，及时的财政管理以及对人类和财务的有效利用 资源。 核心A将确保对所有员工和支持人员进行安全，机构的培训和认可 审查委员会以及机构动物护理和使用目的。核心A还将跟踪学习入学率和 继续对PI的入学人数进行持续审查，以确保患者的总体招聘目标和时间表是 被认识。核心将继续通过每月结构化提供科学协调和互动 季度和年度会议，并将监控项目进度并协助PIS年度进度报告。 既定的外部顾问委员会还将提供监督 具有B细胞生物学，耐受性，感染和表观遗传学的广泛相关专家。核心A将有助于 PPG领导力与外部顾问委员会之间的互动，通过计划和执行 年度会议旨在提供项目更新，讨论正在进行的和未来的研究，并获得目标 有关该计划的整体状态的反馈。核心还将确保及时传播结果和数据 分享项目演示和出版目标。通过简化和合并管理 任务并提供战略领导力以及内部和外部协调，核心A将使项目PIS实现 共同产生严格且有影响力的科学发现，以增加我们对等离子体的理解 细胞并积极影响人类健康。 1